RYR3
ENSG00000198838
Target class
Ion channel
Chromosome
15
Approved drugs
1
Clinical candidates (approved and in development)
1
- Approved drugs
- 1
- ClinGen gene-disease validity
- Limited
- Clinical candidates (approved and in development)
- 1
- Chemical probe available
- No
- Target name
- RYR3
- Gene name
- Ryanodine receptor 3
- Gene symbol
- RYR3
- Protein name
- Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor)
- Gene biotype
- Protein coding
- Gene family
- Ryanodine receptors|EF-hand domain containing
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 35
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 9.55
- Tissue specificity (Gini)
- 0.5
- Tissue specificity (tau)
- 0.733
- KEGG gene identifiers
- hsa:6263
- Protein interaction confidence
- 0.924789
- Protein interaction partners
- 19
- R-HSA-2672351
- R-HSA-5578775
- End position
- 33866121
- Start position
- 33310962
- Chromosome
- 15
- Strand
- Forward
- Sarcoplasmic reticulum membrane
- Multi-pass membrane protein .
- Vesicles
- Tissue specificity (tau)
- 0.733024
- Expression inequality (Gini)
- 0.500084
Expression in transcripts per million
- Uterus
- 9.55
- Brain - Caudate (basal ganglia)
- 7.75
- Brain - Putamen (basal ganglia)
- 7.32
- Colon - Sigmoid
- 7.26
- Muscle - Skeletal
- 6.88
Expression in transcripts per million
- Uterus9.55
- Brain - Caudate (basal ganglia)7.75
- Brain - Putamen (basal ganglia)7.32
- Colon - Sigmoid7.26
- Muscle - Skeletal6.88
- Brain - Cortex6.74
- Brain - Nucleus accumbens (basal ganglia)6.68
- Brain - Anterior cingulate cortex (BA24)6.24
- Brain - Amygdala5.82
- Fallopian Tube5.36
- Brain - Frontal Cortex (BA9)5.11
- Cervix - Endocervix4.97
- Brain - Cerebellum4.68
- Esophagus - Gastroesophageal Junction3.86
- Brain - Hippocampus3.77
- Artery - Aorta3.65
- Artery - Tibial3.38
- Esophagus - Muscularis3.2
- Bladder3.17
- Brain - Substantia nigra3.11
- Brain - Cerebellar Hemisphere2.94
- Cervix - Ectocervix2.9
- Nerve - Tibial2.52
- Brain - Hypothalamus2.46
- Testis2.31
And 29 more, listed on the interactive page.
Biological processes
- GO:0006816
Cellular components
- GO:0033017
- GO:0005219
- GO:0015278
Related records
Trials (231)
- "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
- A Clinical Trial of Dantrolene Sodium in Pediatric and Adult Patients With Wolfram Syndrome
- A Clinical Trial Utilizing Dantrolene in Patients With Ventricular Arrhythmias.
- A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors
- A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine
- A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin
- A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants
- A Placebo-controlled Study to Investigate the Safety, and Pharmacokinetics of Oral GSK626616AC in Healthy Subjects
- A Possible Therapeutic Role for Adenosine During Inflammation
- A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005)
- A Study Evaluating the Potential of BMS-984923 to Alter the Systemic Exposure of Three Orally Administered Probe Substrates
- A Study of Caffeine on Cardiac Arrhythmias
- A Study of Effect of Multiple Doses of LOXO-305 on the Pharmacokinetics of Single Oral Doses of CYP1A2, CYP2C9, CYP2C19 Substrates in Healthy Participants
- A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis
- A Study of LY4515100 in Healthy Participants
- A Study to Assess Effect of JNJ-54861911 on Pharmacokinetics of Cocktail Representatives for Cytochrome P450 (CYP) 3A4, CYP2B6, CYP2C9, and CYP1A2 Substrates
- A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants
- A Study to Compare How Different Substances (Caffeine, Warfarin, Omeprazole, Metoprolol, and Midazolam) Are Handled by the Body of Healthy People and People With Liver Cirrhosis
- A Study to Determine if Caffeine Accelerates Emergence From Anesthesia
- A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia
Drugs (4)
- Adenosine triphosphate
- Caffeine
- Dantrolene Ryanodine receptor 3 antagonist
- Dantrolene sodium Ryanodine receptor 3 antagonist