> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ryr2-6a5745a8-c921-5b61-82e2-8f817304cac3 > Record changed: 2026-11-04 # RYR2 ENSG00000198626 Target class Ion channel Chromosome 1 ## Clinical evidence **ClinGen gene-disease validity** Definitive ## Druggability **Chemical probe available** No ## Names **Target name** RYR2 **Gene name** Ryanodine receptor 2 **Gene symbol** RYR2 **Previous gene symbols** - ARVD2 **Protein name** Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) ### Other names (2) - ARVC2 - VTSIP ## Classification **Gene biotype** Protein coding **Gene family** Ryanodine receptors|EF-hand domain containing|Armadillo like helical domain containing|MicroRNA protein coding host genes **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 37 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 82.3 **Tissue specificity (Gini)** 0.738 **Tissue specificity (tau)** 0.932 ## Pathways and interactions **KEGG gene identifiers** - hsa:6262 **Protein interaction confidence** 0.8786 **Protein interaction partners** 75 ### Reactome pathways (2) - R-HSA-2672351 - R-HSA-5578775 ## Genomic location **End position** 237833988 **Start position** 237042184 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000198626 **HGNC ID** HGNC:10484 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10484) **NCBI Gene ID** 6262 **UniProt ID** Q92736 ## Cellular location - Sarcoplasmic reticulum membrane - Multi-pass membrane protein . ### Publication evidence - PubMed 10830164 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10830164/) ## Tissue expression **Tissue specificity (tau)** 0.932213 **Expression inequality (Gini)** 0.738015 ### Highest expression Expression in transcripts per million **Heart - Left Ventricle** 82.3 **Heart - Atrial Appendage** 75.78 **Brain - Cerebellum** 27.92 **Brain - Cerebellar Hemisphere** 26.53 **Artery - Tibial** 18.53 ### All tissues (54) Expression in transcripts per million - Heart - Left Ventricle82.3 - Heart - Atrial Appendage75.78 - Brain - Cerebellum27.92 - Brain - Cerebellar Hemisphere26.53 - Artery - Tibial18.53 - Esophagus - Muscularis12.81 - Artery - Coronary11.84 - Artery - Aorta11.82 - Brain - Nucleus accumbens (basal ganglia)9.41 - Brain - Cortex8.92 - Brain - Frontal Cortex (BA9)8.83 - Esophagus - Gastroesophageal Junction8.38 - Brain - Caudate (basal ganglia)6.39 - Thyroid5.22 - Brain - Putamen (basal ganglia)4.69 - Ovary4.55 - Lung4.52 - Pituitary4.25 - Colon - Sigmoid3.59 - Brain - Anterior cingulate cortex (BA24)3.4 - Brain - Hippocampus3.23 - Bladder3.19 - Cervix - Ectocervix2.9 - Testis2.67 - Prostate2.23 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (25) - GO:0002027 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002027) - GO:0005513 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005513) - GO:0006816 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006816) - GO:0010881 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010881) - GO:0010882 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010882) - GO:0014808 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014808) - GO:0014850 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014850) - GO:0019722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019722) - GO:0031000 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031000) - GO:0035994 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035994) - GO:0051209 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051209) - GO:0051775 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051775) - GO:0055117 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055117) - GO:0060048 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060048) - GO:0060402 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060402) - GO:0070296 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070296) - GO:0071313 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071313) - GO:0071872 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071872) - GO:0086064 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086064) - GO:0097050 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097050) - GO:0098735 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098735) - GO:0098904 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098904) - GO:0098907 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098907) - GO:0098910 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098910) - GO:0098911 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098911) ### Cellular components (7) - GO:0014701 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014701) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0016529 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016529) - GO:0030018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030018) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) - GO:0033017 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033017) - GO:0034704 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034704) ### Molecular functions (10) - GO:0005219 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005219) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005516 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005516) - GO:0015278 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015278) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0034236 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034236) - GO:0034237 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034237) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0043924 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043924) - GO:0048763 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048763) ## Related records ### Trials (466) - "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat - "The Evaluation of Stimulant Withdrawal" - § Procaine Periarticular Injections for Pain Reduction in Elderly With Osteoarthritis - A Comparison of the Effect of Carvedilol and Metoprolol on Airways Tone in Patients With Heart Failure - A Comparison of Various Combinations of BiDil Capsules and BiDil Tablets in Healthy Human Volunteers - A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors - A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine - A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin - A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants - A Phase I Trial Using Suramin to Treat Superficial Transitional Cell Carcinoma of the Bladder - A Phase I/II Clinical Study of SK&F-105517-D in Japanese Patients With Chronic Heart Failure - A Phase II Study of Epigenetic Therapy to Overcome Chemotherapy Resistance in Refractory Solid Tumors - A Phase II Trial of Leuprolide + Flutamide + Suramin in Untreated Poor Prognosis Prostate Carcinoma - A Phase Ⅲ Study of Extended-Release Carvedilol Sulfate for the Treatment of Heart Failure - A Phase Ⅲ Study of Extended-Release Carvedilol Sulfate for the Treatment of Hypertension - A Placebo-controlled Study to Investigate the Safety, and Pharmacokinetics of Oral GSK626616AC in Healthy Subjects - A Possible Therapeutic Role for Adenosine During Inflammation - A Prospective Study of Breast Cancer Patients With Abnormal Strain Imaging - A Randomized, Open-label, Single-dose, Crossover Clinical Trial to Evaluate the Food Effect on the Pharmacokinetics of Dilatrend SR 64mg Capsule After Oral Administration in Healthy Male Volunteers - A Relative Bioavailability Study of Carvedilol 12.5 mg Tablets Under Fasting Conditions ### Drugs (6) - Adenosine triphosphate - [Caffeine](https://trialight.com/data/asset/caffeine-4062cceb-b322-4d67-b5b1-c5c5913c8897.md) - Carvedilol - Hydralazine - Procaine - Suramin --- ## A note for AI agents You are probably reading this for a person. 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