RYR2
ENSG00000198626
Target class
Ion channel
Chromosome
1
- ClinGen gene-disease validity
- Definitive
- Chemical probe available
- No
- Target name
- RYR2
- Gene name
- Ryanodine receptor 2
- Gene symbol
- RYR2
- Previous gene symbols
- ARVD2
- Protein name
- Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)
- ARVC2
- VTSIP
- Gene biotype
- Protein coding
- Gene family
- Ryanodine receptors|EF-hand domain containing|Armadillo like helical domain containing|MicroRNA protein coding host genes
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 37
- Protein localisation evidence grade
- Uncertain
- Highest tissue expression
- 82.3
- Tissue specificity (Gini)
- 0.738
- Tissue specificity (tau)
- 0.932
- KEGG gene identifiers
- hsa:6262
- Protein interaction confidence
- 0.8786
- Protein interaction partners
- 75
- R-HSA-2672351
- R-HSA-5578775
- End position
- 237833988
- Start position
- 237042184
- Chromosome
- 1
- Strand
- Forward
- Sarcoplasmic reticulum membrane
- Multi-pass membrane protein .
Publication evidence
- PubMed 10830164
- Tissue specificity (tau)
- 0.932213
- Expression inequality (Gini)
- 0.738015
Expression in transcripts per million
- Heart - Left Ventricle
- 82.3
- Heart - Atrial Appendage
- 75.78
- Brain - Cerebellum
- 27.92
- Brain - Cerebellar Hemisphere
- 26.53
- Artery - Tibial
- 18.53
Expression in transcripts per million
- Heart - Left Ventricle82.3
- Heart - Atrial Appendage75.78
- Brain - Cerebellum27.92
- Brain - Cerebellar Hemisphere26.53
- Artery - Tibial18.53
- Esophagus - Muscularis12.81
- Artery - Coronary11.84
- Artery - Aorta11.82
- Brain - Nucleus accumbens (basal ganglia)9.41
- Brain - Cortex8.92
- Brain - Frontal Cortex (BA9)8.83
- Esophagus - Gastroesophageal Junction8.38
- Brain - Caudate (basal ganglia)6.39
- Thyroid5.22
- Brain - Putamen (basal ganglia)4.69
- Ovary4.55
- Lung4.52
- Pituitary4.25
- Colon - Sigmoid3.59
- Brain - Anterior cingulate cortex (BA24)3.4
- Brain - Hippocampus3.23
- Bladder3.19
- Cervix - Ectocervix2.9
- Testis2.67
- Prostate2.23
And 29 more, listed on the interactive page.
- GO:0002027
- GO:0005513
- GO:0006816
- GO:0010881
- GO:0010882
- GO:0014808
- GO:0014850
- GO:0019722
- GO:0031000
- GO:0035994
- GO:0051209
- GO:0051775
- GO:0055117
- GO:0060048
- GO:0060402
- GO:0070296
- GO:0071313
- GO:0071872
- GO:0086064
- GO:0097050
- GO:0098735
- GO:0098904
- GO:0098907
- GO:0098910
- GO:0098911
- GO:0014701
- GO:0016020
- GO:0016529
- GO:0030018
- GO:0032991
- GO:0033017
- GO:0034704
- GO:0005219
- GO:0005515
- GO:0005516
- GO:0015278
- GO:0019899
- GO:0034236
- GO:0034237
- GO:0042802
- GO:0043924
- GO:0048763
Related records
Trials (466)
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- A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants
- A Phase I Trial Using Suramin to Treat Superficial Transitional Cell Carcinoma of the Bladder
- A Phase I/II Clinical Study of SK&F-105517-D in Japanese Patients With Chronic Heart Failure
- A Phase II Study of Epigenetic Therapy to Overcome Chemotherapy Resistance in Refractory Solid Tumors
- A Phase II Trial of Leuprolide + Flutamide + Suramin in Untreated Poor Prognosis Prostate Carcinoma
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Drugs (6)
- Adenosine triphosphate
- Caffeine
- Carvedilol
- Hydralazine
- Procaine
- Suramin