> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ryr1-e49d275a-3e5b-5109-9236-f473b3580497
> Record changed: 2026-11-04

# RYR1

ENSG00000196218

Target class

Ion channel

Chromosome

19

Approved drugs

1

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

1

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

No

## Names

**Target name**

RYR1

**Gene name**

Ryanodine receptor 1

**Gene symbol**

RYR1

**Protein name**

Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)

### Other names (2)

- RYR
- PPP1R137

### Previous gene symbols (3)

- MHS
- MHS1
- CCO

## Classification

**Gene biotype**

Protein coding

**Gene family**

Ryanodine receptors|Protein phosphatase 1 regulatory subunits

**Target class**

Ion channel

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

22

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

423.54

**Tissue specificity (Gini)**

0.885

**Tissue specificity (tau)**

0.994

## Pathways and interactions

**KEGG gene identifiers**

- hsa:6261

**Protein interaction confidence**

0.832

**Protein interaction partners**

70

### Reactome pathways (2)

- R-HSA-2672351
- R-HSA-5578775

## Genomic location

**End position**

38595273

**Start position**

38433691

**Chromosome**

19

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000196218

**HGNC ID**

HGNC:10483

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10483)

**NCBI Gene ID**

6261

**UniProt ID**

P21817

## Cellular location

- Sarcoplasmic reticulum membrane
- Multi-pass membrane protein . Note=The number of predicted transmembrane domains varies between orthologs. Both N-terminus and C-terminus are cytoplasmic. .
- Cytosol
- Golgi apparatus
- Vesicles

### Publication evidence

- PubMed 7556644  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7556644/)

## Tissue expression

**Tissue specificity (tau)**

0.993583

**Expression inequality (Gini)**

0.885199

### Highest expression

Expression in transcripts per million

**Muscle - Skeletal**

423.54

**Brain - Cerebellum**

21.28

**Brain - Cerebellar Hemisphere**

15.42

**Brain - Hypothalamus**

13.56

**Testis**

8.7

### All tissues (54)

Expression in transcripts per million

- Muscle - Skeletal423.54
- Brain - Cerebellum21.28
- Brain - Cerebellar Hemisphere15.42
- Brain - Hypothalamus13.56
- Testis8.7
- Brain - Cortex7.26
- Brain - Anterior cingulate cortex (BA24)6.13
- Brain - Frontal Cortex (BA9)5.93
- Brain - Amygdala5.19
- Brain - Nucleus accumbens (basal ganglia)5.12
- Brain - Caudate (basal ganglia)4.81
- Nerve - Tibial4.79
- Brain - Substantia nigra4.24
- Brain - Spinal cord (cervical c-1)4.09
- Brain - Hippocampus3.5
- Skin - Not Sun Exposed (Suprapubic)2.99
- Brain - Putamen (basal ganglia)2.85
- Skin - Sun Exposed (Lower leg)2.64
- Esophagus - Mucosa2.51
- Minor Salivary Gland1.58
- Vagina1.53
- Breast - Mammary Tissue1.01
- Colon - Sigmoid0.96
- Lung0.95
- Adipose - Visceral (Omentum)0.92

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (6)

- GO:0001666  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001666)
- GO:0006816  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006816)
- GO:0006936  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006936)
- GO:0051209  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051209)
- GO:0070588  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070588)
- GO:0071313  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071313)

### Cellular components (8)

- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005790  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005790)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0005938  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005938)
- GO:0014701  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014701)
- GO:0031674  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031674)
- GO:0033017  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033017)
- GO:0070062  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062)

### Molecular functions (3)

- GO:0005219  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005219)
- GO:0015278  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015278)
- GO:0048763  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048763)

## Related records

### Trials (250)

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- A Study of Effect of Multiple Doses of LOXO-305 on the Pharmacokinetics of Single Oral Doses of CYP1A2, CYP2C9, CYP2C19 Substrates in Healthy Participants
- A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis
- [A Study of LY4515100 in Healthy Participants](https://trialight.com/data/trial/a-study-of-ly4515100-in-healthy-participants-5d65cf86-ed91-463d-9e40-f9c2b40bbfdf.md)
- A Study to Assess Effect of JNJ-54861911 on Pharmacokinetics of Cocktail Representatives for Cytochrome P450 (CYP) 3A4, CYP2B6, CYP2C9, and CYP1A2 Substrates
- A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants

### Drugs (6)

- Adenosine triphosphate
- [Caffeine](https://trialight.com/data/asset/caffeine-4062cceb-b322-4d67-b5b1-c5c5913c8897.md)
- Dantrolene Ryanodine receptor 1 antagonist
- Dantrolene sodium Ryanodine receptor 1 antagonist
- Procaine
- Suramin

---

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