> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/rrm2b-b1c2454b-b304-5721-ace1-10707ba66f06 > Record changed: 2026-10-13 # RRM2B ENSG00000048392 Target class Enzyme Chromosome 8 Approved drugs 5 Clinical candidates (approved and in development) 8 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 8 ## Druggability **Chemical probe available** No ## Names **Other names** - p53R2 **Target name** RRM2B **Gene name** Ribonucleotide reductase regulatory TP53 inducible subunit M2B **Gene symbol** RRM2B **Protein name** Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) ## Classification **Gene biotype** Protein coding **Gene family** Ribonucleotide reductase subunits **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Enhanced **Highest tissue expression** 35.21 **Tissue specificity (Gini)** 0.245 **Tissue specificity (tau)** 0.646 ## Pathways and interactions **KEGG gene identifiers** - hsa:50484 **Protein interaction confidence** 0.847429 **Protein interaction partners** 56 ### Reactome pathways (2) - R-HSA-499943 - R-HSA-5628897 ## Genomic location **End position** 102239382 **Start position** 102204502 **Chromosome** 8 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000048392 **HGNC ID** HGNC:17296 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:17296) **NCBI Gene ID** 50484 **UniProt ID** Q7LG56 ## Cellular location - Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage. - Cytosol - Nucleoplasm ## Tissue expression **Tissue specificity (tau)** 0.646005 **Expression inequality (Gini)** 0.244799 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 35.21 **Thyroid** 33.12 **Cells - Cultured fibroblasts** 25.45 **Artery - Aorta** 21.97 **Lung** 20.72 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes35.21 - Thyroid33.12 - Cells - Cultured fibroblasts25.45 - Artery - Aorta21.97 - Lung20.72 - Pituitary20.44 - Muscle - Skeletal20.37 - Adrenal Gland18.93 - Artery - Coronary18.85 - Brain - Spinal cord (cervical c-1)17.03 - Artery - Tibial15.93 - Nerve - Tibial15.57 - Ovary15.07 - Prostate14.71 - Cervix - Endocervix14.66 - Fallopian Tube14.37 - Uterus14.3 - Adipose - Subcutaneous13.96 - Cervix - Ectocervix13.91 - Brain - Frontal Cortex (BA9)13.52 - Bladder13.08 - Esophagus - Muscularis12.76 - Colon - Sigmoid12.18 - Esophagus - Gastroesophageal Junction12.09 - Brain - Substantia nigra11.86 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0006264 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006264) - GO:0006281 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006281) - GO:0009185 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009185) - GO:0009265 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009265) - GO:0010971 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010971) - GO:0070318 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070318) ### Cellular components (2) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (2) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Related records ### Trials (4,971) - (PGA) for Platinum-resistant/Refractory, Paclitaxel-Pretreated Recurrent Ovarian and Peritoneal Carcinoma - (PM-01) IMPRIME PGG® With BTH1704 and Gemcitabine for Advanced Pancreatic Cancer - 1911GCCC: Galeterone With Gemcitabine for Patients With Metastatic Pancreatic Adenocarcinoma - 1st or 2nd Line MBC (Metastatic Breast Cancer) With Previous Avastin (Bevacizumab) Therapy - 2 Arm Study of Clofarabine IV in MDS Patients - 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia - 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome - ²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myeloma - 225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome - 24BRO681 : Alternating Gnp and mFOLFIRINOX for BR-PDAC - 2nd Line Gemcitabine Monotherapy for Transitional Cell Carcinoma of Urothelium (TCC) After CDDP Regimen - 3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone in Treating Patients With Solid Tumors - 3-AP and Cisplatin in Treating Patients With Recurrent or Persistent Platinum-Resistant Ovarian Epithelial or Primary Peritoneal Cancer - 3-AP and Cytarabine in Treating Patients With Hematologic Cancer - 3-AP and Doxorubicin In Treating Patients With Metastatic or Refractory Solid Tumors - 3-AP and Fludarabine in Treating Patients With Myeloproliferative Disorders, Chronic Myelomonocytic Leukemia, or Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia - 3-AP and Gemcitabine as Second-Line Therapy in Treating Patients With Stage III or Stage IV Recurrent Non-Small Cell Lung Cancer - 3-AP and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma - 3-AP and Gemcitabine in Treating Patients With Metastatic Non-Small Cell Lung Cancer - 3-AP and Gemcitabine in Treating Patients With Recurrent, Unresectable, or Metastatic Pancreatic Cancer ### Drugs (10) - [Clofarabine](https://trialight.com/data/asset/clofarabine-df6136eb-4ce5-4462-8034-d6d6374f0221.md) Ribonucleoside-diphosphate reductase RR1 inhibitor - [Fludarabine phosphate](https://trialight.com/data/asset/fludarabine-phosphate-6e2c2a2e-f158-4f63-89f8-381bbfac5aef.md) Ribonucleoside-diphosphate reductase RR1 inhibitor - Gallium nitrate Ribonucleoside-diphosphate reductase RR1 inhibitor - [Gemcitabine](https://trialight.com/data/asset/gemcitabine-40c84c8f-1f08-4402-bce9-f31ff283382e.md) Ribonucleoside-diphosphate reductase RR1 inhibitor - Gemcitabine hydrochloride Ribonucleoside-diphosphate reductase RR1 inhibitor - [Hydroxyurea](https://trialight.com/data/asset/hydroxyurea-a56eda3c-3ef0-4ca7-b972-656091c627a5.md) Ribonucleoside-diphosphate reductase RR1 inhibitor - Motexafin gadolinium Ribonucleoside-diphosphate reductase RR1 inhibitor - Tezacitabine Ribonucleoside-diphosphate reductase RR1 inhibitor - Tezacitabine anhydrous Ribonucleoside-diphosphate reductase RR1 inhibitor - Triapine Ribonucleotide reductase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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