> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/rrm2-391b8748-e8c4-59d1-9b4e-006b20426d67 > Record changed: 2026-10-13 # RRM2 ENSG00000171848 Target class Enzyme Chromosome 2 Approved drugs 5 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** No ## Names **Other names** - FLJ25102 **Target name** RRM2 **Gene name** Ribonucleotide reductase regulatory subunit M2 **Gene symbol** RRM2 **Previous gene symbols** - C2orf48 **Protein name** Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) ## Classification **Gene biotype** Protein coding **Gene family** Ribonucleotide reductase subunits **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 15 **Protein localisation evidence grade** Supported **Highest tissue expression** 174.48 **Tissue specificity (Gini)** 0.9 **Tissue specificity (tau)** 0.987 ## Pathways and interactions **KEGG gene identifiers** - hsa:6241 **Protein interaction confidence** 0.843069 **Protein interaction partners** 130 ### Reactome pathways (3) - R-HSA-499943 - R-HSA-69205 - R-HSA-8953750 ## Genomic location **End position** 10211725 **Start position** 10120698 **Chromosome** 2 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000171848 **HGNC ID** HGNC:10452 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10452) **NCBI Gene ID** 6241 **UniProt ID** P31350 ## Cellular location - Cytoplasm . Nucleus . Note=Localized to the cytoplasm in S phase cells. May localize to the nucleus in G2 phase cells. . - Cytosol - Nucleoplasm ### Publication evidence - PubMed 22632967 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22632967/) ## Tissue expression **Tissue specificity (tau)** 0.986674 **Expression inequality (Gini)** 0.899917 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 174.48 **Cells - Cultured fibroblasts** 39.77 **Esophagus - Mucosa** 22.89 **Spleen** 11.1 **Small Intestine - Terminal Ileum** 8.18 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes174.48 - Cells - Cultured fibroblasts39.77 - Esophagus - Mucosa22.89 - Spleen11.1 - Small Intestine - Terminal Ileum8.18 - Testis6.59 - Vagina5.51 - Colon - Transverse4.74 - Whole Blood3.27 - Skin - Not Sun Exposed (Suprapubic)2.61 - Lung2.41 - Skin - Sun Exposed (Lower leg)2.38 - Minor Salivary Gland1.24 - Stomach1.23 - Adrenal Gland1.01 - Artery - Coronary0.82 - Artery - Aorta0.66 - Adipose - Visceral (Omentum)0.64 - Cervix - Endocervix0.63 - Adipose - Subcutaneous0.55 - Liver0.54 - Bladder0.52 - Kidney - Medulla0.49 - Prostate0.47 - Breast - Mammary Tissue0.45 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0006281 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006281) - GO:0009185 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009185) - GO:0009265 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009265) - GO:1900087 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900087) ### Cellular components (4) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (4,955) - (PGA) for Platinum-resistant/Refractory, Paclitaxel-Pretreated Recurrent Ovarian and Peritoneal Carcinoma - (PM-01) IMPRIME PGG® With BTH1704 and Gemcitabine for Advanced Pancreatic Cancer - 1911GCCC: Galeterone With Gemcitabine for Patients With Metastatic Pancreatic Adenocarcinoma - 1st or 2nd Line MBC (Metastatic Breast Cancer) With Previous Avastin (Bevacizumab) Therapy - 2 Arm Study of Clofarabine IV in MDS Patients - 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia - 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome - ²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myeloma - 225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome - 24BRO681 : Alternating Gnp and mFOLFIRINOX for BR-PDAC - 2nd Line Gemcitabine Monotherapy for Transitional Cell Carcinoma of Urothelium (TCC) After CDDP Regimen - 3-AP and Fludarabine in Treating Patients With Myeloproliferative Disorders, Chronic Myelomonocytic Leukemia, or Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia - 3-AP and Gemcitabine as Second-Line Therapy in Treating Patients With Stage III or Stage IV Recurrent Non-Small Cell Lung Cancer - 3-AP and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma - 3-AP and Gemcitabine in Treating Patients With Metastatic Non-Small Cell Lung Cancer - 3-AP and Gemcitabine in Treating Patients With Recurrent, Unresectable, or Metastatic Pancreatic Cancer - 3-AP and Gemcitabine in Treating Patients With Refractory Metastatic Breast Cancer - 3-AP and Gemcitabine in Treating Patients With Unresectable or Metastatic Pancreatic Cancer - 3-AP Followed By Fludarabine In Treating Patients With Relapsed or Refractory Acute or Chronic Leukemia or High-Risk Myelodysplastic Syndrome - 3rd Generation GD-2 Chimeric Antigen Receptor and iCaspase Suicide Safety Switch, Neuroblastoma, GRAIN ### Drugs (10) - [Clofarabine](https://trialight.com/data/asset/clofarabine-df6136eb-4ce5-4462-8034-d6d6374f0221.md) Ribonucleoside-diphosphate reductase RR1 inhibitor - [Fludarabine phosphate](https://trialight.com/data/asset/fludarabine-phosphate-6e2c2a2e-f158-4f63-89f8-381bbfac5aef.md) Ribonucleoside-diphosphate reductase RR1 inhibitor - Gallium nitrate Ribonucleoside-diphosphate reductase RR1 inhibitor - [Gemcitabine](https://trialight.com/data/asset/gemcitabine-40c84c8f-1f08-4402-bce9-f31ff283382e.md) Ribonucleoside-diphosphate reductase RR1 inhibitor - Gemcitabine hydrochloride Ribonucleoside-diphosphate reductase RR1 inhibitor - GTI-2040 Ribonucleotide reductase small subunit mRNA antisense inhibitor - [Hydroxyurea](https://trialight.com/data/asset/hydroxyurea-a56eda3c-3ef0-4ca7-b972-656091c627a5.md) Ribonucleoside-diphosphate reductase RR1 inhibitor - Motexafin gadolinium Ribonucleoside-diphosphate reductase RR1 inhibitor - Tezacitabine Ribonucleoside-diphosphate reductase RR1 inhibitor - Tezacitabine anhydrous Ribonucleoside-diphosphate reductase RR1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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