> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/rps6ka1-a197b77e-a5d1-5b43-a684-ec9c901bc17b > Record changed: 2026-11-04 # RPS6KA1 ENSG00000117676 Target class Kinase Chromosome 1 Approved drugs 0 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** Yes ## Names **Target name** RPS6KA1 **Gene name** Ribosomal protein S6 kinase A1 **Gene symbol** RPS6KA1 **Protein name** Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) ### Other names (4) - RSK1 - HU-1 - p90Rsk - MAPKAPK1 ## Classification **Gene biotype** Protein coding **Gene family** MAPK activated protein kinases|MicroRNA protein coding host genes|Ribosomal protein S6 kinase family **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Supported **Highest tissue expression** 180.98 **Tissue specificity (Gini)** 0.592 **Tissue specificity (tau)** 0.903 ## Pathways and interactions **KEGG gene identifiers** - hsa:6195 **Protein interaction confidence** 0.866688 **Protein interaction partners** 32 ### Reactome pathways (8) - R-HSA-198753 - R-HSA-199920 - R-HSA-2559582 - R-HSA-437239 - R-HSA-442742 - R-HSA-444257 - R-HSA-881907 - R-HSA-9856649 ## Genomic location **End position** 26575030 **Start position** 26529756 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000117676 **HGNC ID** HGNC:10430 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10430) **NCBI Gene ID** 6195 **UniProt ID** Q15418 ## Cellular location - Nucleus. Cytoplasm. - Cytosol - Nucleoplasm ## Tissue expression **Tissue specificity (tau)** 0.903421 **Expression inequality (Gini)** 0.591538 ### Highest expression Expression in transcripts per million **Whole Blood** 180.98 **Cells - EBV-transformed lymphocytes** 84.82 **Spleen** 82.69 **Small Intestine - Terminal Ileum** 72.65 **Lung** 65.12 ### All tissues (54) Expression in transcripts per million - Whole Blood180.98 - Cells - EBV-transformed lymphocytes84.82 - Spleen82.69 - Small Intestine - Terminal Ileum72.65 - Lung65.12 - Thyroid47.37 - Colon - Transverse41.93 - Brain - Cerebellar Hemisphere40.5 - Brain - Cerebellum39.24 - Minor Salivary Gland29.07 - Prostate28.92 - Skin - Sun Exposed (Lower leg)25.08 - Skin - Not Sun Exposed (Suprapubic)22.7 - Stomach21.8 - Kidney - Medulla20.7 - Kidney - Cortex20.23 - Pituitary19.72 - Esophagus - Mucosa19.68 - Adrenal Gland18.05 - Vagina15.1 - Breast - Mammary Tissue13.77 - Brain - Spinal cord (cervical c-1)13.24 - Nerve - Tibial11.37 - Testis10.35 - Pancreas10.23 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (11) - GO:0006355 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006355) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007268 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007268) - GO:0030307 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030307) - GO:0032007 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032007) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0043555 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043555) - GO:0045597 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045597) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:2000491 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000491) ### Cellular components (2) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (5) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0004712 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004712) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030165) - GO:0051019 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051019) ## Related records ### Trials (374) - "Neo-Adjuvant Treatment With Palbociclib: Effect on Ki67 and Apoptosis Before, During and After Treatment " - A Biomarker Study of Palbociclib + Fulvestrant for Second, and Third Line of Postmenopausal Women With hr+/her2- Advanced Breast Cancer - A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer - A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease - A Drug-Drug Interaction Study To Investigate The Potential For Multiple Doses Of Palbociclib (PD-0332991) To Alter The Pharmacokinetics Of Oral Midazolam In Adult Healthy Women of Non-Childbearing Potential. - A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors - A First-in-Human Study of D-0502 Alone and in Combination With Palbociclib in Women With Advanced or Metastatic ER-Positive and HER2-Negative Breast Cancer - A Open Label Study of the Efficacy and Safety of PD0332991 a Selective Inhibitor of the Cyclin Dependent Kinases 4 and 6 in Patients With Recurrent Ovarian Cancer Demonstrating Rb-proficiency and Low p16 Expression - A Phase 1 Study in Participants With Advanced Cancer - [A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors](https://trialight.com/data/trial/a-phase-1-study-of-bms-986500-as-monotherapy-or-combination-d34969aa-e987-4889-910e-0aea7d91d410.md) - A Phase 1 Study of Oral OP-1250 in Combination With Palbociclib in HR+/HER2- Breast Cancer Patients - A Phase 1 Trial of TST of PD 0332991 Followed by Cytarabine and Mitoxantrone for Adults With Relapsed and Refractory Acute Leukemias and High-Risk Myelodysplasia - A Phase 1/2 Trial of ARV-471 Alone and in Combination With Palbociclib (IBRANCE®) in Participants With ER+/HER2- Locally Advanced or Metastatic Breast Cancer - A Phase 1/2a Study of K-1728 in Advanced Solid Tumors - A Phase I/II Trial to Evaluate Oral HP568 Tablets in Patients with ER+/HER2 Advanced Breast Cancer - A Phase Ib/II Study Confirmed Inhibition of Autophagy Synergizes Anti-tumor Effect of High Dose CDK4/6i - A Phase Ib/II Study to Evaluate Multiple Combination Therapies of FWD1802 in Patients With ER+/HER2- BC - A Phase II Randomized Study Evaluating the Biological and Clinical Effects of the Combination of Palbociclib With Letrozole as Neoadjuvant Therapy in Post-Menopausal Women With Estrogen-Receptor Positive Primary Breast Cancer - A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) in BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, High Grade Serous Ovarian Cancer, and Metastatic Castrate-Resistant Prostate Cancer - A Phase II Study of Androgen Deprivation Therapy With or Without Palbociclib in RB-Positive Metastatic Prostate Cancer ### Drugs (3) - [Palbociclib](https://trialight.com/data/asset/palbociclib-2686787c-5f11-4b65-9a5b-549fcd2af644.md) - Prexasertib - TAS0612 p90RSK inhibitor --- ## A note for AI agents You are probably reading this for a person. 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