> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ros1-fb26e482-90af-5596-96fa-075f1fa124fb > Record changed: 2026-11-04 # ROS1 ENSG00000047936 Target class Kinase Chromosome 6 Approved drugs 3 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** Yes ## Names **Target name** ROS1 **Gene name** ROS proto-oncogene 1, receptor tyrosine kinase **Gene symbol** ROS1 **Protein name** Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase) ### Other names (3) - MCF3 - ROS - c-ros-1 ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|Fibronectin type III domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 3 **Protein localisation evidence grade** Approved **Highest tissue expression** 11.09 **Tissue specificity (Gini)** 0.939 **Tissue specificity (tau)** 0.989 ## Pathways and interactions **KEGG gene identifiers** - hsa:6098 **Protein interaction confidence** 0.821643 **Protein interaction partners** 14 ## Genomic location **End position** 117425942 **Start position** 117287353 **Chromosome** 6 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000047936 **HGNC ID** HGNC:10261 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10261) **NCBI Gene ID** 6098 **UniProt ID** P08922 ## Cellular location - Cell membrane - Single-pass type I membrane protein . - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.988856 **Expression inequality (Gini)** 0.938713 ### Highest expression Expression in transcripts per million **Lung** 11.09 **Cells - Cultured fibroblasts** 2.96 **Testis** 1.01 **Brain - Cortex** 0.83 **Brain - Frontal Cortex (BA9)** 0.81 ### All tissues (54) Expression in transcripts per million - Lung11.09 - Cells - Cultured fibroblasts2.96 - Testis1.01 - Brain - Cortex0.83 - Brain - Frontal Cortex (BA9)0.81 - Kidney - Medulla0.2 - Brain - Anterior cingulate cortex (BA24)0.11 - Skin - Not Sun Exposed (Suprapubic)0.09 - Colon - Transverse0.09 - Small Intestine - Terminal Ileum0.07 - Kidney - Cortex0.06 - Pituitary0.06 - Stomach0.04 - Muscle - Skeletal0.03 - Fallopian Tube0.02 - Skin - Sun Exposed (Lower leg)0.02 - Cervix - Endocervix0.02 - Liver0.01 - Nerve - Tibial0.01 - Cells - EBV-transformed lymphocytes0.01 - Pancreas0.01 - Heart - Atrial Appendage0.01 - Prostate0.01 - Minor Salivary Gland0.01 - Adipose - Subcutaneous0.01 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0001558 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001558) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0032006 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032006) ### Cellular components - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (3) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019903 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019903) ## Related records ### Trials (334) - -02341066 and PF-00299804 for Advanced Non-Small Cell Lung Cancer - A Clinical Study Testing The Safety And Efficacy Of Crizotinib In East Asian Patients With Anaplastic Lymphoma Kinase (ALK) Positive Advanced Non-Small Cell Lung Cancer - A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051b - A Performance and Bioavailability Study of Entrectinib in Healthy Volunteers. - A Phase 1 Absolute Bioavailability Study For Oral Crizotinib In Healthy Volunteers - A Phase 1 Drug-Drug Interaction Study Between Brigatinib and the CYP3A Substrate, Midazolam, in Participants With ALK-Positive or ROS1-Positive Solid Tumors - A Phase 1 Study to Assess the Effect of Hepatic Impairment on the Pharmacokinetics of Repotrectinib in Advanced Cancer Patients - A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors - [A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)](https://trialight.com/data/trial/a-phase-1-2-study-of-enzomenib-dsp-5336-in-patients-with-0e6145c8-1f49-44ed-a3c6-01e969666e64.md) - A Phase 1b Study Of Axitinib In Combination With Crizotinib In Patients With Advanced Solid Tumors - A Phase 2 Study of Gemtuzumab Ozogamicin (GO)-Gilteritinib Combination in Adults With FLT3-ITD and/or FLT3-TKD Relapse/Refractory (R/R) AML - A Phase I/II Study of Gilteritinib and Momelotinib for Patients With Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia - A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site - A Phase III Study Comparing Taletrectinib With Standard Therapy in ROS1 Positive Locally Advanced or Metastatic Non-small Cell Lung Cancer Patients - A Phase III Study to Evaluate the Efficacy and Safety of JYP0322 in Previously Untreated ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer - A Pilot Study of Crizotinib in Patients With c-MET Positive Gastric Adenocarcinoma as a Third-line Chemotherapy - A Retrospective Study of the Efficacy and Safety of Lolatinib in ALK+ NSCLC Patients With Brain or Meningeal Metastasis - A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study - A Rollover Study of Alectinib in Patients With Anaplastic Lymphoma Kinase (ALK)-Positive or Rearranged During Transfection (RET)-Positive Cancer - A Safety and Efficacy Study of CC-90009 Combinations in Subjects With Acute Myeloid Leukemia ### Drugs (9) - Brigatinib - Crizotinib Proto-oncogene tyrosine-protein kinase ROS inhibitor - Entrectinib Proto-oncogene tyrosine-protein kinase ROS inhibitor - [Gilteritinib](https://trialight.com/data/asset/gilteritinib-68aa5aec-0e4f-4efa-bdc8-eba76c8a8a3a.md) - Lorlatinib - Repotrectinib CD74-ROS1 inhibitor - Taletrectinib Proto-oncogene tyrosine-protein kinase ROS inhibitor - Taletrectinib adipate Proto-oncogene tyrosine-protein kinase ROS inhibitor - [Zidesamtinib](https://trialight.com/data/asset/zidesamtinib-c96e09e2-7a84-4081-858c-ee6f75376d5a.md) --- ## A note for AI agents You are probably reading this for a person. 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