> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/rorb-7b52f341-0519-578d-99cb-c0ac45bebb7d
> Record changed: 2026-11-04

# RORB

ENSG00000198963

Target class

Nuclear receptor

Chromosome

9

## Clinical evidence

**ClinGen gene-disease validity**

Definitive

## Druggability

**Chemical probe available**

No

## Names

**Target name**

RORB

**Gene name**

RAR related orphan receptor B

**Gene symbol**

RORB

**Protein name**

Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)

### Other names (5)

- RZRB
- NR1F2
- ROR-BETA
- RORβ
- RZR-BETA

## Classification

**Gene biotype**

Protein coding

**Gene family**

RAR related orphan receptors

**Target class**

Nuclear receptor

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

19

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

17.02

**Tissue specificity (Gini)**

0.676

**Tissue specificity (tau)**

0.919

## Pathways and interactions

**KEGG gene identifiers**

- hsa:6096

**Protein interaction confidence**

0.873375

**Protein interaction partners**

16

### Reactome pathways (2)

- R-HSA-383280
- R-HSA-9931509

## Genomic location

**End position**

74693177

**Start position**

74497335

**Chromosome**

9

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000198963

**HGNC ID**

HGNC:10259

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10259)

**NCBI Gene ID**

6096

**UniProt ID**

Q92753

## Cellular location

- Nucleus, nucleoplasm .
- Nucleoplasm

### Publication evidence

- PubMed 27352968  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27352968/)

## Tissue expression

**Tissue specificity (tau)**

0.918697

**Expression inequality (Gini)**

0.675799

### Highest expression

Expression in transcripts per million

**Brain - Frontal Cortex (BA9)**

17.02

**Brain - Cortex**

11.32

**Brain - Anterior cingulate cortex (BA24)**

6.14

**Artery - Tibial**

5.66

**Prostate**

4.31

### All tissues (54)

Expression in transcripts per million

- Brain - Frontal Cortex (BA9)17.02
- Brain - Cortex11.32
- Brain - Anterior cingulate cortex (BA24)6.14
- Artery - Tibial5.66
- Prostate4.31
- Brain - Caudate (basal ganglia)4.18
- Brain - Amygdala3.73
- Brain - Hypothalamus3.57
- Brain - Putamen (basal ganglia)3.22
- Brain - Nucleus accumbens (basal ganglia)3.13
- Pituitary2.98
- Cervix - Endocervix1.99
- Adrenal Gland1.99
- Brain - Substantia nigra1.73
- Nerve - Tibial1.62
- Brain - Hippocampus1.61
- Cervix - Ectocervix1.6
- Vagina1.55
- Brain - Cerebellum1.07
- Brain - Cerebellar Hemisphere0.76
- Bladder0.74
- Brain - Spinal cord (cervical c-1)0.73
- Adipose - Visceral (Omentum)0.64
- Adipose - Subcutaneous0.62
- Testis0.58

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes

- GO:0006355  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006355)

### Cellular components

- GO:0005654  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654)

### Molecular functions (3)

- GO:0004879  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004879)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:1990837  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990837)

## Off-target safety

- regulation of transcription factor activity  
### Studies (4)

  - cell-based: ATG\_RORb\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology.
  - cell-based: ATG\_RORb\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology.
  - cell-based: ATG\_RORE\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology.
  - cell-based: ATG\_RORE\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology.  
### Biological samples

  - HepG2, cell line  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (172)

- "AIDA" Protocol (LAP 0493)
- 90Y DOTA/Retinoic Acid for Neuroblastoma and Neuroendocrine Tumor (NET)
- A Clinical Study Evaluating the Efficacy and Safety of Retinoic Acid in Patients With 15q11-q13 Duplication Syndrome
- A Clinical Study to Evaluate the Safety and Effectiveness of an Investigational Product Called CT Gel
- A Comparative Study of Adapalene Gel,0.3% Versus Tretinoin Emollient Cream, 0.05% for the Treatment of Photoaging
- A Fixed Triple Combination Cream for Solar Lentigines Associated to Cryotherapy
- A Pilot Study of 5-AZA and ATRA for Prostate Cancer With PSA-only Recurrence After Local Treatment
- A Single-arm Trial of Roxadustat Combined With Retinoic Acid in the Treatment of Refractory Low-risk MDS
- A Study Comparing Combination Clindamycin Phosphate/Tretinoin Gel Alone Versus With Benzoyl Peroxide Foaming Cloths for Facial Acne
- A Study Comparing Tretinoin Cream 0.025% and RETIN-A® Cream 0.025% in the Treatment of Acne Vulgaris
- [A Study Comparing Tretinoin Gel Microsphere, 0.04% and RETIN-A MICRO ® Gel Microsphere, 0.04% in the Treatment of Acne Vulgaris](https://trialight.com/data/trial/a-study-comparing-tretinoin-gel-microsphere-0-04-and-retin-a-bceeb42d-138a-465f-8e49-d6992398bd3a.md)
- A Study Comparing Tretinoin Gel Microsphere, 0.1% and RETIN-A MICRO ® Gel Microsphere, 0.1% in the Treatment of Acne Vulgaris
- A Study of All-Trans Retinoic Acid (ATRA) and Bryostatin in Patients With Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)
- A Study of ATRA in the Treatment of ITP
- A Study of Bomedemstat (IMG-7289/MK-3543) With and Without ATRA, in Participants With Advanced Myeloid Malignancies (IMG-7289-CTP-101/MK-3543-001)
- A Study of Daratumumab With Pomalidomide, Dexamethasone, and All-Transretinoic Acid in Patients With Multiple Myeloma
- A Study of Different Use Regimens Using Two Acne Treatments
- A Study That Evaluates the Decrease in Irritation When Using Additional Acne Treatment Products
- A Study to Determine the Safety and Efficacy of Atralin (Tretinoin 0.05%) Gel for the Treatment of Rosacea
- A Trial of All-trans Retinoic Acid (ATRA) in Advanced Adenoid Cystic Carcinoma

### Drugs (1)

- [Tretinoin](https://trialight.com/data/asset/tretinoin-4d914613-55d9-4e09-ba53-7b0b1526992b.md)

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