> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ror1-af4a7f63-4559-5599-9f7d-abf429641139
> Record changed: 2026-10-13

# ROR1

ENSG00000185483

Target class

Unclassified protein

Chromosome

1

Approved drugs

0

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

0

**ClinGen gene-disease validity**

Limited

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

No

## Names

**Target name**

ROR1

**Gene name**

Receptor tyrosine kinase like orphan receptor 1

**Gene symbol**

ROR1

**Previous gene symbols**

- NTRKR1

**Protein name**

Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1)

## Classification

**Gene biotype**

Protein coding

**Gene family**

Receptor tyrosine kinases|I-set domain containing|Kringle domain containing

**Target class**

Unclassified protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

34

**Highest tissue expression**

18.25

**Tissue specificity (Gini)**

0.573

**Tissue specificity (tau)**

0.85

## Pathways and interactions

**KEGG gene identifiers**

- hsa:4919

**Reactome pathways**

- R-HSA-5140745

**Protein interaction confidence**

0.785077

**Protein interaction partners**

13

## Genomic location

**End position**

64181498

**Start position**

63774017

**Chromosome**

1

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000185483

**HGNC ID**

HGNC:10256

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10256)

**NCBI Gene ID**

4919

**UniProt ID**

Q01973

## Cellular location

- Membrane
- Single-pass type I membrane protein. Cell projection, axon .

### Publication evidence

- PubMed 27162350  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27162350/)

## Tissue expression

**Tissue specificity (tau)**

0.849749

**Expression inequality (Gini)**

0.573076

### Highest expression

Expression in transcripts per million

**Artery - Tibial**

18.25

**Cells - Cultured fibroblasts**

14.08

**Artery - Aorta**

11.28

**Artery - Coronary**

9.21

**Cervix - Endocervix**

7.84

### All tissues (54)

Expression in transcripts per million

- Artery - Tibial18.25
- Cells - Cultured fibroblasts14.08
- Artery - Aorta11.28
- Artery - Coronary9.21
- Cervix - Endocervix7.84
- Colon - Sigmoid6.83
- Cervix - Ectocervix6.5
- Nerve - Tibial6.17
- Uterus6.07
- Stomach5.7
- Ovary5.67
- Lung4.96
- Adipose - Visceral (Omentum)3.92
- Fallopian Tube3.89
- Bladder3.82
- Vagina3.34
- Adipose - Subcutaneous3.2
- Skin - Sun Exposed (Lower leg)3.16
- Skin - Not Sun Exposed (Suprapubic)2.85
- Prostate2.83
- Esophagus - Mucosa2.71
- Esophagus - Gastroesophageal Junction2.66
- Colon - Transverse2.53
- Breast - Mammary Tissue2.48
- Pancreas2.25

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (4)

- GO:0007169  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007169)
- GO:0007605  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007605)
- GO:0008283  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008283)
- GO:0043123  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123)

### Cellular components (4)

- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)
- GO:0043235  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235)

### Molecular functions (7)

- GO:0004714  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0005524  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005524)
- GO:0015026  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015026)
- GO:0017147  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017147)
- GO:0038023  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038023)
- GO:0042813  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042813)

## Related records

### Trials (17)

- [A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)](https://trialight.com/data/trial/a-clinical-study-of-zilovertamab-vedotin-mk-2140-plus-134b8f98-3329-4e9d-af03-b73bfdbc1295.md)
- A Study of Cirmtuzumab and Ibrutinib in Patients With B-Cell Lymphoid Malignancies
- A Study of Zilovertamab and Ibrutinib in Patients With Relapsed or Refractory Mantle Cell Lymphoma
- A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001)
- A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)
- A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007)
- A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)
- A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002)
- [A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)](https://trialight.com/data/trial/a-study-to-evaluate-zilovertamab-vedotin-mk-2140-combination-47c43a74-d190-4960-aac9-afe2cea567bf.md)
- A Study to Evaluate Zilovertamab Vedotin (MK-2140) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-004)
- A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)
- Cirmtuzumab Consolidation for Treatment of Patients With Detectable CLL on Venetoclax
- Extension Study of UC-961 (Cirmtuzumab) for Patients With Chronic Lymphocytic Leukemia Treated Previously With UC-961
- Study of Cirmtuzumab and Paclitaxel for Metastatic or Locally Advanced, Unresectable Breast Cancer
- Study of Docetaxel Combined with Cirmtuzumab in Metastatic Castration Resistant Prostate Cancer
- Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
- UC-961 (Cirmtuzumab) in Relapsed or Refractory Chronic Lymphocytic Leukemia

### Drugs (1)

- [Cirmtuzumab](https://trialight.com/data/asset/cirmtuzumab-2e8f54d4-5214-4698-8544-18a9d77e438c.md) Inactive tyrosine-protein kinase transmembrane receptor ROR1 inhibitor

---

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