> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/rock2-069b3cc1-7311-56e5-b052-b0a31caaaf52 > Record changed: 2026-10-13 # ROCK2 ENSG00000134318 Target class Kinase Chromosome 2 Approved drugs 3 Clinical candidates (approved and in development) 12 ## Clinical evidence **Approved drugs** 3 **ClinGen gene-disease validity** Limited **Clinical candidates (approved and in development)** 12 ## Druggability **Chemical probe available** Yes ## Names **Target name** ROCK2 **Gene name** Rho associated coiled-coil containing protein kinase 2 **Gene symbol** ROCK2 **Protein name** Rho-associated protein kinase 2 (EC 2.7.11.39) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) ## Classification **Gene biotype** Protein coding **Gene family** Pleckstrin homology domain containing|Rho associated coiled-coil containing protein kinase family **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 61.42 **Tissue specificity (Gini)** 0.352 **Tissue specificity (tau)** 0.672 ## Pathways and interactions **KEGG gene identifiers** - hsa:9475 **Protein interaction confidence** 0.889128 **Protein interaction partners** 46 ### Reactome pathways (12) - R-HSA-3928662 - R-HSA-3928663 - R-HSA-416482 - R-HSA-416572 - R-HSA-4420097 - R-HSA-5627117 - R-HSA-8980692 - R-HSA-9013026 - R-HSA-9013106 - R-HSA-9013407 - R-HSA-9013422 - R-HSA-9679191 ## Genomic location **End position** 11348330 **Start position** 11179759 **Chromosome** 2 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000134318 **HGNC ID** HGNC:10252 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10252) **NCBI Gene ID** 9475 **UniProt ID** O75116 ## Cellular location - Cytoplasm. Cell membrane - Peripheral membrane protein . Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane. . - Cytosol ## Tissue expression **Tissue specificity (tau)** 0.672441 **Expression inequality (Gini)** 0.35154 ### Highest expression Expression in transcripts per million **Artery - Tibial** 61.42 **Adipose - Subcutaneous** 46.93 **Uterus** 44.61 **Artery - Aorta** 43.62 **Artery - Coronary** 42.12 ### All tissues (54) Expression in transcripts per million - Artery - Tibial61.42 - Adipose - Subcutaneous46.93 - Uterus44.61 - Artery - Aorta43.62 - Artery - Coronary42.12 - Brain - Cerebellar Hemisphere38.15 - Cells - Cultured fibroblasts36.76 - Lung36.35 - Bladder35.76 - Adipose - Visceral (Omentum)34.74 - Breast - Mammary Tissue33.32 - Brain - Cerebellum32.38 - Cervix - Endocervix32.11 - Esophagus - Muscularis31.95 - Fallopian Tube31.02 - Cervix - Ectocervix30.75 - Nerve - Tibial29.75 - Esophagus - Gastroesophageal Junction29.58 - Ovary23.71 - Muscle - Skeletal23.08 - Colon - Sigmoid22.62 - Colon - Transverse20.49 - Thyroid20.27 - Vagina20.14 - Spleen19.49 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (23) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0006939 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006939) - GO:0007266 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007266) - GO:0016525 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016525) - GO:0030155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030155) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0032956 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032956) - GO:0044788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044788) - GO:0045019 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045019) - GO:0045616 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045616) - GO:0051298 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051298) - GO:0051492 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051492) - GO:0051496 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051496) - GO:0051893 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051893) - GO:0072659 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072659) - GO:0150033 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0150033) - GO:1902004 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902004) - GO:1902966 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902966) - GO:1902993 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902993) - GO:1903140 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903140) - GO:1903347 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903347) - GO:2000114 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000114) - GO:2000145 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000145) ### Cellular components (4) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005813) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0036464 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036464) ### Molecular functions (6) - GO:0002020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002020) - GO:0003723 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003723) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0061133 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061133) - GO:0072518 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072518) ## On-target safety - pulmonary hypertension ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - respiratory PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - GI disorder ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - GI PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Anxiety ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - heart disease ### Studies - preclinical: Important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Pro-fibrotic and pro-apoptotic in the setting of pressure overload ### Biological samples - cardiovascular system PubMed 21283106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/) - nervous system disorder ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - cardiac dysfunction ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - lymphatic disorder ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - lymph PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - cytopenia ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - blood/bone marrow PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Memory impairment ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Related records ### Trials (115) - 24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients - A 2-Part, Phase 2 Open-label and Crossover Study of Belumosudil for Treatment of Idiopathic Pulmonary Fibrosis - A Clinical Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Belumosudil in Chinese Adolescents With cGVHD Who Have Had an Inadequate Response to Glucocorticoids or Other Systemic Therapies - A Clinical Trial of Safety and Efficacy of Fasudil in Subjects With Amyotrophic Lateral Sclerosis (ALS) - A Controlled Study of the Aqueous Humor Dynamics of AR-13324 Ophthalmic Solution in Healthy Adult Volunteers - A Dose Titration Study to Assess the Effects of SAR407899 in Patients With MVA and/or Persistent Stable Angina Despite Angiographically Successful PCI - A Multi-Center Study on the Use of Rho-Kinase Inhibitor to Reduce or Prevent PVR in RRD Eyes at High Risk for PVR - A Phase 2 Study Evaluating the Safety and Efficacy of Netarsudil Ophthalmic Solution in Patients With Corneal Edema Due to Fuchs Corneal Dystrophy - A Phase 2, Double-blind, Placebo-controlled Study of the Efficacy and Safety of Belumosudil in Subjects With Moderate/Severe Chronic Plaque Psoriasis - A Rho-kinase Inhibitor (Fasudil) in the Treatment of Raynaud's Phenomenon - A Safety and Tolerability Study of Belumosudil (KD025) Treatment in Subjects With Moderately Severe Psoriasis Vulgaris - A Single Centre Study to Evaluate 3 Ophthalmic Formulations in Healthy Subjects - A Study of Belumosudil in Children With Chronic Graft Versus Host Disease (schoolROCK) - A Study of Belumosudil in People at Risk of Developing Graft-Versus-Host Disease After a Stem Cell Transplant - A Study of Efficacy and Safety of PHP-201 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension - A Study to Assess the Effect of Oral Belumosudil on Inhibition of Various Proteins in the Fed State in Healthy Male Subjects - A Study to Determine the Effect of 500 mg Oral Dose of KD025 in Healthy Male and Post-menopausal Female Subjects - A Study to Determine the Effect of Multiple Oral Doses and Regimens of KD025 in Healthy Male and Post-menopausal Female Subjects - A Study to Determine the Effect of Multiple Oral Doses of SLx-2119 in Healthy Male Subjects - A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD) ### Drugs (14) - AMA0076 Rho-associated protein kinase inhibitor - AT-13148 Rho-associated protein kinase inhibitor - Belumosudil Rho-associated protein kinase 2 inhibitor - Belumosudil mesylate Rho-associated protein kinase inhibitor - DE-104 Rho-associated protein kinase inhibitor - Fasudil Rho-associated protein kinase inhibitor - [Netarsudil](https://trialight.com/data/asset/netarsudil-cdf69483-92c3-4ac8-b941-7366b7bf529a.md) Rho-associated protein kinase inhibitor - Netarsudil dimesylate Rho-associated protein kinase inhibitor - Ripasudil Rho-associated protein kinase inhibitor - Ripasudil hydrochloride dihydrate Rho-associated protein kinase inhibitor - SAR-407899 Rho-associated protein kinase inhibitor - SAR-407899 FREE BASE Rho-associated protein kinase inhibitor - Verosudil Rho-associated protein kinase inhibitor - Y-39983 Rho-associated protein kinase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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