> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ripk1-93a69f78-746d-50b7-aa21-6d9306596592
> Record changed: 2026-11-04

# RIPK1

ENSG00000137275

Target class

Kinase

Chromosome

6

Approved drugs

0

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

0

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

RIPK1

**Gene name**

Receptor interacting serine/threonine kinase 1

**Gene symbol**

RIPK1

**Protein name**

Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)

### Other names (3)

- RIP
- RIP1
- RIP-1

## Classification

**Gene biotype**

Protein coding

**Gene family**

Ripoptosome|Receptor interacting serine/threonine kinase family

**Target class**

Kinase

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

37.69

**Tissue specificity (Gini)**

0.281

**Tissue specificity (tau)**

0.424

## Pathways and interactions

**KEGG gene identifiers**

- hsa:8737

**Protein interaction confidence**

0.904247

**Protein interaction partners**

97

### Reactome pathways (24)

- R-HSA-140534
- R-HSA-168927
- R-HSA-1810476
- R-HSA-2562578
- R-HSA-3295583
- R-HSA-3371378
- R-HSA-5213460
- R-HSA-5218900
- R-HSA-5357786
- R-HSA-5357905
- R-HSA-5357956
- R-HSA-5675482
- R-HSA-5689880
- R-HSA-5689896
- R-HSA-69416
- R-HSA-75893
- R-HSA-9013957
- R-HSA-933543
- R-HSA-937041
- R-HSA-9679191
- R-HSA-9686347
- R-HSA-9692913
- R-HSA-9693928
- R-HSA-9920951

## Genomic location

**End position**

3115187

**Start position**

3063824

**Chromosome**

6

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000137275

**HGNC ID**

HGNC:10019

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:10019)

**NCBI Gene ID**

8737

**UniProt ID**

Q13546

## Cellular location

- Cytoplasm . Cell membrane .
- Cytosol
- Plasma membrane

## Tissue expression

**Tissue specificity (tau)**

0.423555

**Expression inequality (Gini)**

0.280909

### Highest expression

Expression in transcripts per million

**Skin - Sun Exposed (Lower leg)**

37.69

**Adipose - Subcutaneous**

37.18

**Skin - Not Sun Exposed (Suprapubic)**

36.57

**Spleen**

35.95

**Small Intestine - Terminal Ileum**

35.11

### All tissues (54)

Expression in transcripts per million

- Skin - Sun Exposed (Lower leg)37.69
- Adipose - Subcutaneous37.18
- Skin - Not Sun Exposed (Suprapubic)36.57
- Spleen35.95
- Small Intestine - Terminal Ileum35.11
- Thyroid34.94
- Uterus34.61
- Bladder34.13
- Fallopian Tube32.89
- Nerve - Tibial32.24
- Lung32.09
- Artery - Tibial32.04
- Breast - Mammary Tissue31.98
- Cells - Cultured fibroblasts31.24
- Cervix - Endocervix31.1
- Colon - Sigmoid30.95
- Esophagus - Gastroesophageal Junction30.55
- Artery - Coronary30.37
- Adipose - Visceral (Omentum)30.3
- Esophagus - Muscularis29.92
- Vagina29.43
- Cervix - Ectocervix29.42
- Prostate29.06
- Esophagus - Mucosa27.97
- Colon - Transverse27.79

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (32)

- GO:0006915  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006915)
- GO:0006979  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006979)
- GO:0007249  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007249)
- GO:0010628  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628)
- GO:0032147  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032147)
- GO:0032757  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032757)
- GO:0032760  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032760)
- GO:0033209  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033209)
- GO:0034612  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034612)
- GO:0035556  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556)
- GO:0043065  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043065)
- GO:0043068  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043068)
- GO:0043123  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123)
- GO:0043124  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043124)
- GO:0045651  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045651)
- GO:0045944  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944)
- GO:0046330  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046330)
- GO:0050729  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050729)
- GO:0060545  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060545)
- GO:0062100  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0062100)
- GO:0070105  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070105)
- GO:0070266  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070266)
- GO:0071356  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071356)
- GO:0097191  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097191)
- GO:0097343  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097343)

And 7 more, listed on the interactive page.

### Cellular components (8)

- GO:0005739  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0010008  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008)
- GO:0031264  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031264)
- GO:0032991  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991)
- GO:0043235  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235)
- GO:0097342  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097342)

### Molecular functions (11)

- GO:0004672  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004672)
- GO:0004674  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674)
- GO:0005123  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005123)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0031625  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031625)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)
- GO:0042803  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803)
- GO:0044877  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044877)
- GO:0070513  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070513)
- GO:0106310  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106310)
- GO:0120283  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0120283)

## Related records

### Trials (86)

- A Drug Interaction Study of LY3871801 in Healthy Participants
- A Phase 1b Trial to Evaluate Safety and Effect of SAR443122 on Immune System in Severe COVID-19
- A Phase 2 Trial of Ponatinib in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor
- A Phase II Study of the Combination of Ponatinib With Mini-hyper CVD Chemotherapy and Venetoclax in Patients With Relapsed or Refractory T-cell Acute Lymphoblastic Leukemia
- A Safety and Pharmacokinetic (PK) Study of GSK2982772 in Healthy Subjects
- A Safety and Tolerability Study of GSK2982772, in Single (in Both Fed and Fasted States) and Repeat Oral Doses in Healthy Male Subjects
- A Study Comparing Ponatinib and Nilotinib in Participants With Chronic Myeloid Leukemia
- A Study in Healthy Adult Male & Female Participants to Assess the Amount of the Study Medicine (SAR443820) Absorbed by the Body, When Given Orally in Fasted Condition as a Tablet Versus as a Capsule (Part 1) and When Given Orally as a Tablet in Fasted Condition Versus as a Tablet After Food (Part 2)
- A Study of Carbon-14-Labelled \[14C\] LY3871801 in Healthy Male Participants
- A Study of LY3871801 in Healthy Asian and Non-Asian Participants
- A Study of LY3871801 in Healthy Participants
- A Study of Ponatinib in Japanese Participants With Chronic Myeloid Leukemia (CML) and Ph+ Acute Lymphoblastic Leukemia (ALL)
- A Study of Ponatinib Versus Imatinib in Adults With Acute Lymphoblastic Leukemia
- A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
- A Study to Assess the Effect of Erythromycin on the Test Medicine (SAR443820) When Given Orally as Tablets to Healthy Adult Male and Female Participants (Part A); and the Effect of Itraconazole on the Test Medicine (SAR443820) When Given Orally as Capsules to Healthy Adult Male Participants (Part B)
- A Study to Assess the Safety and Pharmacokinetics of GDC-8264 in Combination With Standard of Care in Participants With Acute Graft-Versus-Host Disease (aGVHD)
- A Study to Compare the Pharmacokinetics (PK) of GSK2982772 Following Administration of Different Modified Release (MR) Formulations in Capsule and MR Tablet Formulations Relative to an Immediate Release (IR) Tablet Formulation and to Check the PK of MR Formulation in Capsule Following Repeat Doses
- A Study to Evaluate the Benefit and Safety of GSK2982772 in Moderate to Severe Psoriasis Participants
- A Study to Evaluate the Effect of SAR443820 on Serum Neurofilament Levels in Male and Female Adult Participants With Multiple Sclerosis
- A Study to Evaluate the Efficacy and Safety of GDC-8264 in Preventing Cardiac Surgery-Associated Acute Kidney Injury (AKI) and Major Adverse Kidney Events (MAKE)

### Drugs (6)

- Eclitasertib
- Flizasertib
- GSK2982772 Receptor-interacting serine/threonine-protein kinase 1 inhibitor
- Ocadusertib
- [Oditrasertib](https://trialight.com/data/asset/oditrasertib-c75ee3d7-8d17-43fa-80cc-5474ac2cd10b.md)
- Ponatinib

---

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