RET

ENSG00000165731
Target class
Kinase
Chromosome
10
Approved drugs
9
Clinical candidates (approved and in development)
15

Approved drugs
9
ClinGen gene-disease validity
Definitive
Clinical candidates (approved and in development)
15

Chemical probe available
Yes

Target name
RET
Gene name
Ret proto-oncogene
Gene symbol
RET
Protein name
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]

  • PTC
  • CDHF12
  • RET51
  • CDHR16

  • HSCR1
  • MEN2A
  • MTC1
  • MEN2B

Gene biotype
Protein coding
Gene family
Cadherin related|Receptor tyrosine kinases
Target class
Kinase
Target type
Human gene

Tissues expressed in
21
Protein localisation evidence grade
Approved
Highest tissue expression
6.3
Tissue specificity (Gini)
0.497
Tissue specificity (tau)
0.806

KEGG gene identifiers
  • hsa:5979
Protein interaction confidence
0.851297
Protein interaction partners
64

  • R-HSA-5673001
  • R-HSA-8853659
  • R-HSA-9768919
  • R-HSA-9830364
  • R-HSA-9830674

End position
43130351
Start position
43077026
Chromosome
10
Strand
Forward

Ensembl gene ID
ENSG00000165731
HGNC ID
HGNC:9967
www.genenames.org
NCBI Gene ID
5979
UniProt ID
P07949

  • Cell membrane
  • Single-pass type I membrane protein . Endosome membrane
  • Single-pass type I membrane protein . Note=Predominantly located on the plasma membrane (PubMed:23333276, PubMed:9575150). In the presence of SORL1 and GFRA1, directed to endosomes (PubMed:23333276). .
  • Cytosol
  • Golgi apparatus
  • Plasma membrane

Tissue specificity (tau)
0.8056
Expression inequality (Gini)
0.496994

Expression in transcripts per million

Brain - Substantia nigra
6.3
Pituitary
4.82
Brain - Cerebellum
4.03
Colon - Sigmoid
4.02
Brain - Frontal Cortex (BA9)
3.76

Expression in transcripts per million

  • Brain - Substantia nigra6.3
  • Pituitary4.82
  • Brain - Cerebellum4.03
  • Colon - Sigmoid4.02
  • Brain - Frontal Cortex (BA9)3.76
  • Brain - Hypothalamus3.73
  • Testis3.25
  • Brain - Cerebellar Hemisphere2.8
  • Brain - Cortex2.76
  • Colon - Transverse1.9
  • Esophagus - Muscularis1.87
  • Brain - Anterior cingulate cortex (BA24)1.86
  • Stomach1.8
  • Esophagus - Gastroesophageal Junction1.77
  • Cervix - Endocervix1.72
  • Prostate1.47
  • Vagina1.39
  • Cervix - Ectocervix1.25
  • Adipose - Visceral (Omentum)1.2
  • Adrenal Gland1.17
  • Small Intestine - Terminal Ileum1.02
  • Breast - Mammary Tissue0.99
  • Adipose - Subcutaneous0.98
  • Thyroid0.94
  • Uterus0.94

And 29 more, listed on the interactive page.

Related records

Trials (1,801)

Drugs (18)