> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ren-0583f8fa-2894-58b0-88c4-9248e87248e8 > Record changed: 2026-10-13 # REN ENSG00000143839 Target class Enzyme Chromosome 1 Approved drugs 1 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** Yes ## Names **Target name** REN **Gene name** Renin **Gene symbol** REN **Protein name** Renin (EC 3.4.23.15) (Angiotensinogenase) ## Classification **Gene biotype** Protein coding **Gene family** Peptidase family A1 **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 7 **Highest tissue expression** 48.2 **Tissue specificity (Gini)** 0.906 **Tissue specificity (tau)** 0.986 ## Pathways and interactions **KEGG gene identifiers** - hsa:5972 **Reactome pathways** - R-HSA-2022377 **Protein interaction confidence** 0.811442 **Protein interaction partners** 52 ## Genomic location **End position** 204190324 **Start position** 204154815 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000143839 **HGNC ID** HGNC:9958 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9958) **NCBI Gene ID** 5972 **UniProt ID** P00797 ## Cellular location - Secreted . Membrane . Note=Associated to membranes via binding to ATP6AP2\. . ### Publication evidence - PubMed 12045255 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12045255/) ## Tissue expression **Tissue specificity (tau)** 0.986464 **Expression inequality (Gini)** 0.906414 ### Highest expression Expression in transcripts per million **Kidney - Cortex** 48.2 **Ovary** 13.16 **Kidney - Medulla** 7.6 **Uterus** 2.72 **Fallopian Tube** 1.8 ### All tissues (54) Expression in transcripts per million - Kidney - Cortex48.2 - Ovary13.16 - Kidney - Medulla7.6 - Uterus2.72 - Fallopian Tube1.8 - Cervix - Endocervix1.8 - Testis1.42 - Adrenal Gland0.66 - Bladder0.41 - Liver0.37 - Vagina0.35 - Minor Salivary Gland0.32 - Heart - Atrial Appendage0.3 - Prostate0.28 - Cervix - Ectocervix0.28 - Lung0.26 - Pituitary0.24 - Skin - Sun Exposed (Lower leg)0.23 - Esophagus - Mucosa0.2 - Spleen0.16 - Nerve - Tibial0.16 - Adipose - Visceral (Omentum)0.14 - Breast - Mammary Tissue0.13 - Skin - Not Sun Exposed (Suprapubic)0.13 - Brain - Substantia nigra0.12 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0001822 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001822) - GO:0002003 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002003) - GO:0006508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006508) - GO:0008217 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008217) - GO:0043408 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043408) ### Cellular components (4) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0045177 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045177) ### Molecular functions (4) - GO:0004190 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004190) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008233 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008233) ## Related records ### Trials (165) - "ALOFT - Aliskiren Observation of Heart Failure Treatment": Efficacy and Safety of Aliskiren Added on Top of Standard Therapy in Adults (≥ 18 Years) With Stable Heart Failure - 52-104 Week Off-therapy Second Extension to Study CSPP100A2365 - 8 Weeks Study to Evaluate the Efficacy and Safety of Valsartan in Combination With Aliskiren Compared to Valsartan Alone in Patients With Stage 2 Hypertension - 8-week Randomized, Open-label Study to Evaluate Food Effect on Efficacy and Safety of Oral Aliskiren 300 mg in Patients With Hypertension - A Clinical Study to Assess Efficacy and Safety of Aliskiren in the Elderly With High Blood Pressure - A Clinical Study to Compare an Aliskiren Based Hypertensive Regimen With a Ramipril Based One Followed by a Randomized Withdrawal. - A Clinical Study to Compare Combination of Aliskiren+ HCTZ to Irbesartan+ HCTZ or Amlodipine+ HCTZ or HCTZ Alone in Obese Hypertensive Not Responsive to HCTZ 25 mg - A Clinical Study to Compare Long-term Efficacy and Safety of an Aliskiren Based Regimen to a Hydrochlorothiazide Based Treatment Regimen With Optional Addition of Amlodipine - A Clinical Study to Compare Long-term Efficacy and Safety of an Aliskiren Based Regimen to a Hydrochlorothiazidebased Treatment Regimen With Optional Addition of Amlodipine - A Clinical Study to Compare the Safety and Efficacy of an Aliskiren-based Regimen With a Lisinopril Based Regimen in Patients With Severe Hypertension - A Clinical Study to Evaluate Renal Hemodynamic Responses to Aliskiren in Patients With Type 2 Diabetes Mellitus - A Clinical Study to Evaluate Safety & Efficacy of the Combination of Aliskiren, Valsartan & Hydrochlorothiazide in Diabetic Hypertensive Nonresponder Patients - A Clinical Study to Evaluate the Long-term Safety (12 Months) of the Combination of Aliskiren 300 mg and Hydrochlorothiazide 25 mg - A Clinical Study to Evaluate the Safety and Efficacy of Aliskiren Alone and in Combination With Ramipril in Hypertensive, Diabetic Patients. - A Clinical Study to Evaluate the Safety and Efficacy of the Combination of Aliskiren and Amlodipine in Hypertensive Non Responders Patients - A Clinical Study to Evaluate the Safety and Efficacy of the Combination of Aliskiren and Valsartan in Hypertensive Non Responders Patients - A Clinical Study With Aliskiren Alone or in Combination Therapy With Diuretic Hctz in Venezuelan Hypertensive Patients. - A Dose Ranging Study to Compare the Safety and Efficacy of Aliskiren 150mg, 300mg, and 600mg to Placebo in Patients With High Blood Pressure. - A Dose Ranging Study to Compare the Safety and Efficacy of Aliskiren in Patients With High Blood Pressure - A Long Term Safety Study to Test the Combination of Aliskiren/ Amlodipine / Hydrochlorothiazide in Participants With Essential Hypertension ### Drugs (5) - Aliskiren Renin inhibitor - Aliskiren fumarate Renin inhibitor - Imarikiren Renin inhibitor - Imarikiren hydrochloride Renin inhibitor - [Sitokiren](https://trialight.com/data/asset/sitokiren-919706e4-b027-48f9-8591-75fe1dcdba63.md) Renin inhibitor --- ## A note for AI agents You are probably reading this for a person. 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