> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/rbx1-84bf5aec-13d0-56fa-b3c2-574a7e5dee8e > Record changed: 2026-10-13 # RBX1 ENSG00000100387 Target class Enzyme Chromosome 22 Approved drugs 4 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 4 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** No ## Names **Target name** RBX1 **Gene name** Ring-box 1 **Gene symbol** RBX1 **Protein name** E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) \[Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)\] ### Other names (3) - ROC1 - RNF75 - BA554C12.1 ## Classification **Gene biotype** Protein coding **Gene family** Ring finger proteins|SCF complex core subunits **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 169.61 **Tissue specificity (Gini)** 0.156 **Tissue specificity (tau)** 0.59 ## Pathways and interactions **KEGG gene identifiers** - hsa:9978 **Protein interaction confidence** 0.898049 **Protein interaction partners** 247 ### Reactome pathways (41) - R-HSA-110314 - R-HSA-1170546 - R-HSA-1234176 - R-HSA-180585 - R-HSA-195253 - R-HSA-2122947 - R-HSA-2644606 - R-HSA-2644607 - R-HSA-2894862 - R-HSA-4641258 - R-HSA-5610780 - R-HSA-5610783 - R-HSA-5610785 - R-HSA-5632684 - R-HSA-5658442 - R-HSA-5696394 - R-HSA-5696395 - R-HSA-5696400 - R-HSA-6781823 - R-HSA-6781827 - R-HSA-6782135 - R-HSA-6782210 - R-HSA-68949 - R-HSA-69601 - R-HSA-8854050 And 16 more, listed on the interactive page. ## Genomic location **End position** 40973539 **Start position** 40951277 **Chromosome** 22 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000100387 **HGNC ID** HGNC:9928 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9928) **NCBI Gene ID** 9978 **UniProt ID** P62877 ## Cellular location - Cytoplasm . Nucleus . - Nucleoplasm ### Publication evidence - PubMed 11027288 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11027288/) ## Tissue expression **Tissue specificity (tau)** 0.589765 **Expression inequality (Gini)** 0.156483 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 169.61 **Cells - Cultured fibroblasts** 117.93 **Brain - Spinal cord (cervical c-1)** 114.31 **Brain - Cerebellar Hemisphere** 97.83 **Nerve - Tibial** 90.23 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes169.61 - Cells - Cultured fibroblasts117.93 - Brain - Spinal cord (cervical c-1)114.31 - Brain - Cerebellar Hemisphere97.83 - Nerve - Tibial90.23 - Cervix - Ectocervix89.17 - Brain - Frontal Cortex (BA9)88.59 - Thyroid85.3 - Brain - Hypothalamus84.31 - Cervix - Endocervix82.95 - Lung82.89 - Artery - Coronary82.23 - Artery - Aorta81.66 - Uterus80.91 - Esophagus - Mucosa79.48 - Brain - Cerebellum79.45 - Vagina77.88 - Artery - Tibial76.9 - Brain - Substantia nigra76.8 - Brain - Anterior cingulate cortex (BA24)76.46 - Skin - Sun Exposed (Lower leg)74.69 - Fallopian Tube74.67 - Skin - Not Sun Exposed (Suprapubic)74.44 - Spleen72.46 - Adipose - Subcutaneous71.72 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (38) - GO:0000165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000165) - GO:0000209 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000209) - GO:0006283 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006283) - GO:0006511 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006511) - GO:0006513 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006513) - GO:0006974 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006974) - GO:0007283 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007283) - GO:0016485 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016485) - GO:0016567 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016567) - GO:0031146 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031146) - GO:0032436 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032436) - GO:0032480 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032480) - GO:0034599 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034599) - GO:0034644 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034644) - GO:0042110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042110) - GO:0042770 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042770) - GO:0043123 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123) - GO:0043124 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043124) - GO:0043161 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043161) - GO:0043687 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043687) - GO:0044314 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044314) - GO:0045116 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045116) - GO:0045724 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045724) - GO:0045732 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045732) - GO:0045879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045879) And 13 more, listed on the interactive page. ### Cellular components (15) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0019005 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019005) - GO:0031461 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031461) - GO:0031462 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031462) - GO:0031463 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031463) - GO:0031464 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031464) - GO:0031465 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031465) - GO:0031466 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031466) - GO:0031467 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031467) - GO:0080008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0080008) - GO:0090734 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090734) ### Molecular functions (10) - GO:0004842 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004842) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019788) - GO:0031625 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031625) - GO:0034450 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034450) - GO:0060090 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060090) - GO:0061629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061629) - GO:0061630 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061630) - GO:0061663 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061663) - GO:0097602 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097602) ## Related records ### Trials (1,854) - "Monoclonal Antibodies for Treatment of Multiple Myeloma. Emphasis on the CD38 Antibody Daratumumab " - \[Effects of Selected Statins on Cardiovascular Parameters in Healthy Volunteers\] - 1454GCC: Anti-PD-1 (MK-3475) and IMiD (Pomalidomide) Combination Immunotherapy in Relapsed/Refractory Multiple Myeloma - 2015-09: a Phase II Randomized, Open-label Study of Anti-signaling Lymphocytic Activation Molecule Monoclonal Antibody During Maintenance Therapy - 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy - 2017-03: A Single-Arm, Open-label Study of Anti-Signaling Lymphocytic Activation Molecule F7 (Anti-SLAMF7) Monoclonal Antibody (mAb) Therapy After Autologous Stem Cell Transplant in Patients With Multiple Myeloma - 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Fasting - 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Non-Fasting - 5-Azacytidine With Lenalidomide in Patients With High Risk Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML) - A 2 Stage Trial of Lenalidomide (REV) in Asymptomatic Ovarian Cancer Patients With Increasing CA 125 in Late Relapse - A Bioequivalence Study Comparing A Fixed Dose Combination Formulation Of Myrin P Forte That Contains Rifampicin, Isoniazid, Ethambutol And Pyrazinamide Per Tablet To An Equivalent Dose Of Single Drug Reference Preparations Of Similar Combination Following Oral Administration In Healthy Adults - A Clinical Study Comparing SG301 Plus Pomalidomide and Dexamethasone to Placebo Plus Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma Patients - A Clinical Study of Injectable IMM0306 in Combination With Lenalidomide - A Clinical Study to Test the Effects of Ruxolitinib And Thalidomide Combination for Patients With Myelofibrosis - A Clinical Trial of PGDM1400 and PGT121 and VRC07-523LS Monoclonal Antibodies in HIV-infected and HIV-uninfected Adults - A Clinical Trial to Evaluate the Efficacy and Safety of TQB3909 Tablets Versus Investigator's Choice in the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) - A Companion Study for Studies THAL-MM-003, CC-5013-MM-009, and CC-5013-MM-010 for Subjects With Multiple Myeloma - A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis - A Dose Escalation Study of Lenalidomide in Relapsed or Refractory B-cell Chronic Lymphocytic Leukemia - A Dose Escalation Study of the Combination of Lenalidomide (Revlimid®), Dexamethasone and Cyclophosphamide in Patients Refractory or Relapsing From Stable Disease With Multiple Myeloma ### Drugs (5) - Iberdomide CRL4(CRBN) E3 ubiquitin ligase modulator - [Lenalidomide](https://trialight.com/data/asset/lenalidomide-1e614dfb-efd0-4006-a121-30a97656c7a9.md) CRL4(CRBN) E3 ubiquitin ligase inhibitor; CRL4(CRBN) E3 ubiquitin ligase modulator - Lenalidomide hydrochloride monohydrate CRL4(CRBN) E3 ubiquitin ligase modulator - [Pomalidomide](https://trialight.com/data/asset/pomalidomide-8cab22f9-2d15-4e50-9ef9-334f56340121.md) CRL4(CRBN) E3 ubiquitin ligase inhibitor - Thalidomide CRL4(CRBN) E3 ubiquitin ligase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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