> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/rarb-eabf3c7d-d020-5984-bdd9-707b0a22fd15 > Record changed: 2026-10-13 # RARB ENSG00000077092 Target class Nuclear receptor Chromosome 3 Approved drugs 8 Clinical candidates (approved and in development) 10 ## Clinical evidence **Approved drugs** 8 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 10 ## Druggability **Chemical probe available** Yes ## Names **Target name** RARB **Gene name** Retinoic acid receptor beta **Gene symbol** RARB **Protein name** Retinoic acid receptor beta (RAR-beta) (HBV-activated protein) (Nuclear receptor subfamily 1 group B member 2) (RAR-epsilon) ### Other names (5) - HAP - NR1B2 - RRB2 - RARbeta - RAR-beta ## Classification **Gene biotype** Protein coding **Gene family** Retinoic acid receptors **Target class** Nuclear receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 50 **Protein localisation evidence grade** Enhanced **Highest tissue expression** 24.35 **Tissue specificity (Gini)** 0.437 **Tissue specificity (tau)** 0.734 ## Pathways and interactions **KEGG gene identifiers** - hsa:5915 **Protein interaction confidence** 0.854944 **Protein interaction partners** 18 ### Reactome pathways (3) - R-HSA-383280 - R-HSA-5362517 - R-HSA-5617472 ## Genomic location **End position** 25597932 **Start position** 24687887 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000077092 **HGNC ID** HGNC:9865 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9865) **NCBI Gene ID** 5915 **UniProt ID** P10826 ## Cellular location - Nucleus . Cytoplasm . - SUBCELLULAR LOCATION: \[Isoform Beta-1\]: Nucleus. - SUBCELLULAR LOCATION: \[Isoform Beta-2\]: Nucleus. - SUBCELLULAR LOCATION: \[Isoform Beta-4\]: Cytoplasm. - Nucleoplasm ### Publication evidence - PubMed 28167758 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28167758/) ## Tissue expression **Tissue specificity (tau)** 0.733935 **Expression inequality (Gini)** 0.436643 ### Highest expression Expression in transcripts per million **Esophagus - Muscularis** 24.35 **Uterus** 15.63 **Cervix - Endocervix** 15.39 **Prostate** 15.16 **Nerve - Tibial** 15.11 ### All tissues (54) Expression in transcripts per million - Esophagus - Muscularis24.35 - Uterus15.63 - Cervix - Endocervix15.39 - Prostate15.16 - Nerve - Tibial15.11 - Thyroid14.65 - Brain - Nucleus accumbens (basal ganglia)13.54 - Cervix - Ectocervix13.48 - Esophagus - Gastroesophageal Junction13.25 - Pituitary12.69 - Bladder11.64 - Artery - Tibial11.58 - Ovary11.07 - Vagina10.97 - Minor Salivary Gland10.22 - Artery - Coronary9.95 - Colon - Sigmoid9.65 - Brain - Caudate (basal ganglia)9.54 - Fallopian Tube9.18 - Lung9.04 - Brain - Frontal Cortex (BA9)8.34 - Heart - Atrial Appendage7.44 - Kidney - Medulla6.7 - Brain - Putamen (basal ganglia)6.5 - Brain - Cortex6.35 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0048566 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048566) ### Cellular components (3) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) ### Molecular functions (3) - GO:0003677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677) - GO:0004879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004879) - GO:1990837 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990837) ## Off-target safety - regulation of transcription factor activity ### Studies (4) - cell-based: ATG\_RARb\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: ATG\_DR5\_RAR\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: ATG\_RARb\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: ATG\_DR5\_RAR\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. ### Biological samples - HepG2, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (564) - "A Comparative Clinical Evaluation of the Efficacy of Topical Adapalene, Benzoyl Peroxide Gel, Oral Lactobacillus Rhamnosus, D-chiro-inositol, Inulin Capsule, and Their Fixed Combination in Mild to Moderate Acne Vulgaris Patients." - "AIDA" Protocol (LAP 0493) - 13-cis Retinoic Acid (Isotretinoin) and Sperm Production - 13-Cis Retinoic Acid With or Without Vitamin E for Prevention of Lung Cancer - 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of First Remission After Non-Myeloablative Therapy in Patients With High-Risk Neuroblastoma - 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of Second or Greater Remission of High-Risk Neuroblastoma - 90Y DOTA/Retinoic Acid for Neuroblastoma and Neuroendocrine Tumor (NET) - A 24 Week Trial to Compare the Efficacy and Safety of Delgocitinib Cream 20 mg/g Twice-daily With Alitretinoin Capsules Once-daily in Adult Participants With Severe Chronic Hand Eczema - A Bioavailability Study of DFD-03 Compared to Tazorac® in Patients With Moderate Acne Vulgaris - A Bioequivalence Study With Clinical Endpoints Comparing Adapalene and Benzoyl Peroxide Topical Gel 0.1%/2.5% (Actavis Mid-Atlantic LLC) To Epiduo™ (Adapalene and Benzoyl Peroxide) Gel 0.1%/2.5% (Galderma Laboratories, L.P.) in the Treatment of Mild to Severe Acne Vulgaris - A Biomarker-Directed Phase 2 Trial of Tamibarotene (SY-1425) in Participants With Acute Myeloid Leukemia or Myelodysplastic Syndrome - A Clinical Study Evaluating the Efficacy and Safety of Retinoic Acid in Patients With 15q11-q13 Duplication Syndrome - A Clinical Study on the Efficacy and Safety of All-trans Retinoic Acid Combined With VAC Regimen in the Treatment of Intermediate-to-high-risk Rhabdomyosarcoma - A Clinical Study to Evaluate the Safety and Effectiveness of an Investigational Product Called CT Gel - A Companion Treatment Study for Patients With Moderate to Severe Acne Vulgaris - A Comparative Study of Adapalene Gel,0.3% Versus Tretinoin Emollient Cream, 0.05% for the Treatment of Photoaging - A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne - A Demonstration of the Hair and Scalp Benefits of Duobrii in Scalp Psoriasis - A Phase 3 Study to Compare the Safety and Efficacy of 5% Dapsone Topical Gel, (DTG) Twice Daily in Combination With Once Daily Vehicle Control, Adapalene Gel 0.1% or Benzoyl Peroxide Gel 4% - A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (301) ### Drugs (10) - Acitretin Retinoid receptor agonist - [Adapalene](https://trialight.com/data/asset/adapalene-3faa801e-ff34-482b-86c4-5ca9ef98b2b7.md) Retinoic acid receptor agonist - Alitretinoin Retinoid receptor agonist - Etretinate Retinoid receptor agonist - IRX4310 Retinoic acid receptor antagonist - Isotretinoin Retinoic acid receptor agonist - Mofarotene Retinoid receptor modulator - Tamibarotene Retinoic acid receptor beta agonist - Tazarotene Retinoic acid receptor agonist - [Tretinoin](https://trialight.com/data/asset/tretinoin-4d914613-55d9-4e09-ba53-7b0b1526992b.md) Retinoic acid receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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