> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ramp3-250b6cba-f92f-5ed4-9284-a906d7ff7537 > Record changed: 2026-11-04 # RAMP3 ENSG00000122679 Target class Unclassified protein Chromosome 7 Approved drugs 1 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** No ## Names **Target name** RAMP3 **Gene name** Receptor activity modifying protein 3 **Gene symbol** RAMP3 **Protein name** Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3) ## Classification **Gene biotype** Protein coding **Gene family** Receptor (G protein-coupled) activity modifying proteins **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Protein localisation evidence grade** Supported **Highest tissue expression** 220.44 **Tissue specificity (Gini)** 0.506 **Tissue specificity (tau)** 0.841 ## Pathways and interactions **KEGG gene identifiers** - hsa:10268 **Protein interaction confidence** 0.910733 **Protein interaction partners** 15 ### Reactome pathways (2) - R-HSA-418555 - R-HSA-419812 ## Genomic location **End position** 45188665 **Start position** 45157648 **Chromosome** 7 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000122679 **HGNC ID** HGNC:9845 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9845) **NCBI Gene ID** 10268 **UniProt ID** O60896 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Membrane - Single-pass type I membrane protein . Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner. - Plasma membrane ### Publication evidence (2) - PubMed 23674134 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23674134/) - PubMed 32296767 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32296767/) ## Tissue expression **Tissue specificity (tau)** 0.840639 **Expression inequality (Gini)** 0.50581 ### Highest expression Expression in transcripts per million **Lung** 220.44 **Thyroid** 137.33 **Adipose - Subcutaneous** 126.28 **Brain - Spinal cord (cervical c-1)** 115.11 **Breast - Mammary Tissue** 100.52 ### All tissues (54) Expression in transcripts per million - Lung220.44 - Thyroid137.33 - Adipose - Subcutaneous126.28 - Brain - Spinal cord (cervical c-1)115.11 - Breast - Mammary Tissue100.52 - Adipose - Visceral (Omentum)85.04 - Kidney - Medulla76.78 - Artery - Coronary67.75 - Kidney - Cortex65.93 - Nerve - Tibial59.05 - Uterus57.23 - Cervix - Endocervix56.59 - Esophagus - Gastroesophageal Junction52.48 - Esophagus - Muscularis48.59 - Vagina47.14 - Prostate46.99 - Fallopian Tube46.83 - Heart - Atrial Appendage40.96 - Bladder40.58 - Small Intestine - Terminal Ileum38.78 - Adrenal Gland36.13 - Heart - Left Ventricle35.31 - Cervix - Ectocervix33.1 - Skin - Sun Exposed (Lower leg)30.46 - Colon - Sigmoid30.14 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (16) - GO:0001921 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001921) - GO:0006816 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006816) - GO:0007189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0015031 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015031) - GO:0031623 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031623) - GO:0050850 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050850) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0070374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374) - GO:0072659 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072659) - GO:0097647 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097647) - GO:0141163 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0141163) - GO:0150061 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0150061) - GO:1903078 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903078) - GO:1904645 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904645) - GO:1990410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990410) ### Cellular components (7) - GO:0005764 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) - GO:0150058 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0150058) - GO:1903143 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903143) ### Molecular functions (6) - GO:0001540 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001540) - GO:0001605 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001605) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015026 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015026) - GO:0030545 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030545) - GO:0097643 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097643) ## Related records ### Trials (132) - A Dose Selection Study of Oral Recombinant Salmon Calcitonin (rsCT) in Normal, Healthy, Postmenopausal Women - A Fully Automated Lyumjev and Pramlintide Delivery System for Adults With Type 1 Diabetes - A Fully-closed Loop, Pramlintide and Insulin, Artificial Pancreas Clinical Trial for Adults With Type 1 Diabetes - A Pilot Study of Continuous Subcutaneous Pramlintide Infusion Therapy in Patients With Type 1 Diabetes - A Research Study Looking at How a Single Dose of the Medicine Cagrilintide Works in Participants With Reduced Liver Function and in Healthy Participants With Normal Liver Function and How Cagrilintide is Absorbed and Used by the Body - A Research Study Looking at How Cagrilintide Works on the Heart Rhythm in Healthy Participants - A Research Study Looking Into Blood Levels of NNC0174-0833 in People With Normal and Impaired Kidney Function - A Research Study Looking Into How Cagrilintide Influences Food Intake and Appetite in People With Overweight or Obesity - A Research Study of How NNC0174-0833 Behaves in Chinese Volunteers Who Are Normal Weight, Overweight or With Obesity - A Research Study of How NNC0174-0833 Behaves in Japanese and Caucasian Volunteers Who Are Normal Weight, Overweight or With Obesity - A Research Study of How NNC0174-0833 Taken With Semaglutide Works in People Who Are Overweight or Obese - A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight - A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Combined Versus Separate Injections in People With Overweight or Obesity - A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Single Doses of Different Versions of Injectable CagriSema in Adults With Overweight or Obesity - A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body Weight - A Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body Weight - A Research Study to Compare Two Different Versions of Injectable CagriSema in People With Type 2 Diabetes - A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy - A Research Study to Look at How CagriSema Influences Food Intake, Appetite and Emptying of the Stomach in People With Excess Body Weight - [A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight](https://trialight.com/data/trial/a-research-study-to-look-at-how-two-different-doses-of-76a42b8a-318d-4ae8-8ea2-46e58c1e3a81.md) ### Drugs (8) - Adrenomedullin - [Cagrilintide](https://trialight.com/data/asset/cagrilintide-83b81776-3caf-4dea-a1a9-64bd998ac431.md) - Calcitonin - Calcitonin human - Calcitonin salmon - Davalintide - Pramlintide Amylin receptor AMY3; CALCR/RAMP3 agonist - Pramlintide acetate Amylin receptor AMY3; CALCR/RAMP3 agonist --- ## A note for AI agents You are probably reading this for a person. 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