> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ramp1-304d5657-b31c-5ac4-bfab-a6382a086a28 > Record changed: 2026-11-04 # RAMP1 ENSG00000132329 Target class Other membrane protein Chromosome 2 Approved drugs 2 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** RAMP1 **Gene name** Receptor activity modifying protein 1 **Gene symbol** RAMP1 **Protein name** Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1) ## Classification **Gene biotype** Protein coding **Gene family** Receptor (G protein-coupled) activity modifying proteins **Target class** Other membrane protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Approved **Highest tissue expression** 901.83 **Tissue specificity (Gini)** 0.622 **Tissue specificity (tau)** 0.878 ## Pathways and interactions **KEGG gene identifiers** - hsa:10267 **Protein interaction confidence** 0.880053 **Protein interaction partners** 19 ### Reactome pathways (2) - R-HSA-418555 - R-HSA-419812 ## Genomic location **End position** 237912111 **Start position** 237858893 **Chromosome** 2 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000132329 **HGNC ID** HGNC:9843 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9843) **NCBI Gene ID** 10267 **UniProt ID** O60894 ## Cellular location - Cell membrane - Single-pass type I membrane protein . - Nuclear membrane - Nucleoplasm ### Publication evidence - PubMed 33602864 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33602864/) ## Tissue expression **Tissue specificity (tau)** 0.877936 **Expression inequality (Gini)** 0.621741 ### Highest expression Expression in transcripts per million **Uterus** 901.83 **Artery - Aorta** 595.93 **Cervix - Endocervix** 546.83 **Cervix - Ectocervix** 463 **Colon - Sigmoid** 389.46 ### All tissues (54) Expression in transcripts per million - Uterus901.83 - Artery - Aorta595.93 - Cervix - Endocervix546.83 - Cervix - Ectocervix463 - Colon - Sigmoid389.46 - Fallopian Tube360.41 - Artery - Coronary300.12 - Artery - Tibial282.86 - Esophagus - Gastroesophageal Junction255.43 - Bladder224.44 - Esophagus - Muscularis217.45 - Prostate156.83 - Brain - Nucleus accumbens (basal ganglia)126.21 - Heart - Left Ventricle103.01 - Heart - Atrial Appendage101.08 - Colon - Transverse97.89 - Brain - Amygdala95.33 - Brain - Anterior cingulate cortex (BA24)93.78 - Brain - Caudate (basal ganglia)93.05 - Muscle - Skeletal91.23 - Brain - Frontal Cortex (BA9)89.43 - Brain - Cortex88.62 - Brain - Hippocampus87.99 - Brain - Substantia nigra85.99 - Brain - Hypothalamus84.36 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (10) - GO:0001525 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001525) - GO:0006816 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006816) - GO:0007189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189) - GO:0010560 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010560) - GO:0015031 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015031) - GO:0031623 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031623) - GO:0072659 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072659) - GO:0097647 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097647) - GO:0150059 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0150059) - GO:1990408 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990408) ### Cellular components (4) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) - GO:1990406 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990406) ### Molecular functions (5) - GO:0001635 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001635) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015026 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015026) - GO:0097643 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097643) - GO:1990407 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990407) ## Related records ### Trials (281) - 12-Week Placebo-controlled Study of Atogepant for the Preventive Treatment of Migraine in Participants With Episodic Migraine - A Clinical Trial of Rimegepant for Vestibular Migraine Evaluation: Pre-experiment - A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache - A Controlled Trial of Erenumab in Migraine Prevention - A Dose Selection Study of Oral Recombinant Salmon Calcitonin (rsCT) in Normal, Healthy, Postmenopausal Women - A Dose-Finding Study of MK-1602 in the Treatment of Acute Migraine (MK-1602-006) - A Dose-Finding Study of MK0974 in Acute Migraine (MK0974-004) - A Fully Automated Lyumjev and Pramlintide Delivery System for Adults With Type 1 Diabetes - A Fully-closed Loop, Pramlintide and Insulin, Artificial Pancreas Clinical Trial for Adults With Type 1 Diabetes - A Functional MRI Study on Erenumab Treatment Effects in Episodic Migraine Patients - A Long-Term Safety and Tolerability Extension Study Evaluating Atogepant for the Prevention of Chronic or Episodic Migraine - A Pharmacokinetic Study of MK-1602 in the Treatment of Acute Migraine (MK-1602-007) - A Pilot Study of Continuous Subcutaneous Pramlintide Infusion Therapy in Patients With Type 1 Diabetes - A Prospective Real World Study of Rimegepant in the Treatment of Migraine - A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency Department - A Randomized, Open-Label, Multi-Center Study of Vestibular Migraine Prevention: Rimegepant Versus Flunarizine Non-inferiority Study - A Registry Study on Rimegepant for the Treatment of Migraine Participants in Guangdong-Hong Kong-Macao Greater Bay Area - A Safety and Efficacy Study to Evaluate AMG 334 in Migraine Prevention - A Study Comparing Oral Calcitonin to Nasal Spray Calcitonin in Postmenopausal Osteoporotic Women - A Study Evaluating Oral Atogepant for the Prevention of Migraine in Japanese Participants With Chronic or Episodic Migraine ### Drugs (16) - Adrenomedullin - [Atogepant](https://trialight.com/data/asset/atogepant-06c1e020-1758-4b06-8f37-1c53649d9a0b.md) - Calcitonin - Calcitonin human - Calcitonin salmon - Davalintide Amylin receptor AMY1, CALCR/RAMP1 agonist - Davalintide acetate Amylin receptor AMY1, CALCR/RAMP1 agonist - Erenumab - HTL-0022562 - Olcegepant - Pramlintide Amylin receptor AMY1, CALCR/RAMP1 agonist - Pramlintide acetate Amylin receptor AMY1, CALCR/RAMP1 agonist - [Rimegepant](https://trialight.com/data/asset/rimegepant-c1207159-0a84-4344-9a8d-b5dc577a317a.md) - Telcagepant - [Ubrogepant](https://trialight.com/data/asset/ubrogepant-8361e028-0d26-4b8f-97d3-849085bb72c3.md) - [Zavegepant](https://trialight.com/data/asset/zavegepant-f0d53974-a354-467a-a023-a528b34d96e9.md) Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 antagonist --- ## A note for AI agents You are probably reading this for a person. 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