> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ptk2b-f32e1aa9-5335-57b8-9c94-c2e17dec2c61 > Record changed: 2026-11-04 # PTK2B ENSG00000120899 Target class Kinase Chromosome 8 Approved drugs 0 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** Yes ## Names **Target name** PTK2B **Gene name** Protein tyrosine kinase 2 beta **Gene symbol** PTK2B **Previous gene symbols** - FAK2 **Protein name** Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) ### Other names (5) - CAKB - PYK2 - RAFTK - PTK - CADTK ## Classification **Gene biotype** Protein coding **Gene family** Minor histocompatibility antigens|FERM domain containing|PTK2 family tyrosine kinases|MicroRNA protein coding host genes **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 233.14 **Tissue specificity (Gini)** 0.547 **Tissue specificity (tau)** 0.841 ## Pathways and interactions **KEGG gene identifiers** - hsa:2185 **Protein interaction confidence** 0.883228 **Protein interaction partners** 57 ### Reactome pathways (4) - R-HSA-391160 - R-HSA-4420097 - R-HSA-9013420 - R-HSA-9020558 ## Genomic location **End position** 27459392 **Start position** 27311456 **Chromosome** 8 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000120899 **HGNC ID** HGNC:9612 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9612) **NCBI Gene ID** 2185 **UniProt ID** Q14289 ## Cellular location - Cytoplasm. Cytoplasm, perinuclear region. Cell membrane - Peripheral membrane protein - Cytoplasmic side. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cell cortex. Nucleus. Note=Interaction with NPHP1 induces the membrane-association of the kinase. Colocalizes with integrins at the cell periphery. - Cytosol - Plasma membrane ## Tissue expression **Tissue specificity (tau)** 0.840716 **Expression inequality (Gini)** 0.547228 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 233.14 **Brain - Cerebellar Hemisphere** 230.8 **Brain - Cerebellum** 220.79 **Whole Blood** 119.63 **Brain - Frontal Cortex (BA9)** 116.58 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes233.14 - Brain - Cerebellar Hemisphere230.8 - Brain - Cerebellum220.79 - Whole Blood119.63 - Brain - Frontal Cortex (BA9)116.58 - Spleen105.96 - Brain - Cortex105.57 - Brain - Nucleus accumbens (basal ganglia)60.35 - Brain - Anterior cingulate cortex (BA24)59.69 - Brain - Hippocampus55.36 - Skin - Not Sun Exposed (Suprapubic)52.44 - Small Intestine - Terminal Ileum49.73 - Lung47 - Skin - Sun Exposed (Lower leg)46.92 - Prostate41.3 - Brain - Amygdala33.44 - Minor Salivary Gland31.8 - Brain - Caudate (basal ganglia)30.25 - Fallopian Tube27.61 - Colon - Transverse26.86 - Nerve - Tibial25.47 - Adipose - Visceral (Omentum)25.37 - Vagina24.24 - Esophagus - Mucosa22.16 - Brain - Putamen (basal ganglia)21.52 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (30) - GO:0001954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001954) - GO:0006915 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006915) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0007229 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007229) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0008360 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008360) - GO:0010595 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010595) - GO:0010976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010976) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0030155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030155) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0030838 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030838) - GO:0033209 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033209) - GO:0038083 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038083) - GO:0042976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042976) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0043267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043267) - GO:0045638 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045638) - GO:0045860 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045860) - GO:0046330 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046330) - GO:0046777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777) - GO:0048010 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048010) - GO:0048167 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048167) And 5 more, listed on the interactive page. ### Cellular components (8) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0014069 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014069) - GO:0030027 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030027) - GO:0048471 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471) ### Molecular functions (3) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (109) - 5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours - A Phase 1 Dose Escalation Study of VS-5584 Administered in Combination With VS-6063, in Subjects With Relapsed Malignant Mesothelioma - [A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors](https://trialight.com/data/trial/a-phase-1-2-study-of-vs-7375-in-patients-with-kras-g12d-2a83cb8c-fe8d-4b5c-88de-0eebb2025cdc.md) - A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib - A Phase I, Open-label Study of Absorption, Metabolism, and Excretion of Defactinib (VS-6063) in Healthy Male Subjects - A Retrospective Study of the Efficacy and Safety of Lolatinib in ALK+ NSCLC Patients With Brain or Meningeal Metastasis - A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer - A Study of Avutometinib (VS-6766) + Defactinib in Recurrent KRAS G12V, Other KRAS and BRAF Non-Small Cell Lung Cancer - A Study of Avutometinib (VS-6766) and Defactinib in People With Mesonephric Gynecologic Cancer - A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation - A Study of Avutometinib + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer in Japanese Patients - A Study of Avutometinib and Defactinib in People With Thyroid Cancer - A Study of Avutometinib, Defactinib, and Letrozole in People With Low-Grade Serous Ovarian Cancer - A Study of Lorlatinib in Advanced ALK and ROS1 Rearranged Lung Cancer With CNS Metastasis in the Absence of Measurable Extracranial Lesions - A Study of Lorlatinib in ALK Inhibitor-Treated ALK-Positive NSCLC in China - A Study of Lorlatinib in Combination With Ramucirumab in People With Lung Cancer - A Study of Lorlatinib in Subjects With ROS1-Positive Non-Small Cell Lung Cancer - A Study Of Lorlatinib Versus Crizotinib In First Line Treatment Of Patients With ALK-Positive NSCLC - A Study of Oral Lorlatinib in Patients With Relapsed ALK Positive Lymphoma - A Study Of PF-04554878 In Patients With Advanced Non-Hematologic Malignancies ### Drugs (5) - Conteltinib Protein tyrosine kinase 2 beta inhibitor - [Defactinib](https://trialight.com/data/asset/defactinib-93d3f8e7-960f-4e54-9e6e-fd0a1504d053.md) Protein tyrosine kinase 2 beta inhibitor - Defactinib hydrochloride Protein tyrosine kinase 2 beta inhibitor - Lorlatinib - PF-00562271 --- ## A note for AI agents You are probably reading this for a person. 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