> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ptk2-b2d6adf1-0ce8-54d4-b3f7-44b2db6f9811 > Record changed: 2026-11-04 # PTK2 ENSG00000169398 Target class Kinase Chromosome 8 Approved drugs 0 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** Yes ## Names **Target name** PTK2 **Gene name** Protein tyrosine kinase 2 **Gene symbol** PTK2 **Protein name** Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) ### Other names (4) - FAK - FADK - FAK1 - PPP1R71 ## Classification **Gene biotype** Protein coding **Gene family** Protein phosphatase 1 regulatory subunits|FERM domain containing|PTK2 family tyrosine kinases|MicroRNA protein coding host genes **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Supported **Highest tissue expression** 51.69 **Tissue specificity (Gini)** 0.236 **Tissue specificity (tau)** 0.656 ## Pathways and interactions **KEGG gene identifiers** - hsa:5747 **Protein interaction confidence** 0.884782 **Protein interaction partners** 156 ### Reactome pathways (17) - R-HSA-111465 - R-HSA-2029482 - R-HSA-354192 - R-HSA-354194 - R-HSA-372708 - R-HSA-375165 - R-HSA-391160 - R-HSA-3928662 - R-HSA-418885 - R-HSA-4420097 - R-HSA-5663213 - R-HSA-5673001 - R-HSA-8874081 - R-HSA-9009391 - R-HSA-9634638 - R-HSA-9664422 - R-HSA-9860927 ## Genomic location **End position** 141002216 **Start position** 140657900 **Chromosome** 8 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000169398 **HGNC ID** HGNC:9611 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9611) **NCBI Gene ID** 5747 **UniProt ID** Q05397 ## Cellular location - Cell junction, focal adhesion . Cell membrane - Peripheral membrane protein - Cytoplasmic side . Cytoplasm, perinuclear region . Cytoplasm, cell cortex. Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm . Note=Constituent of focal adhesions. Detected at microtubules. . - Cytosol - Focal adhesion sites ### Publication evidence (6) - PubMed 10655584 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10655584/) - PubMed 15855171 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15855171/) - PubMed 18206965 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18206965/) - PubMed 18256281 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18256281/) - PubMed 31630787 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/31630787/) - PubMed 18078954 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18078954/) ## Tissue expression **Tissue specificity (tau)** 0.655552 **Expression inequality (Gini)** 0.235848 ### Highest expression Expression in transcripts per million **Artery - Tibial** 51.69 **Artery - Coronary** 32.38 **Nerve - Tibial** 31.05 **Brain - Spinal cord (cervical c-1)** 28.63 **Artery - Aorta** 28.08 ### All tissues (54) Expression in transcripts per million - Artery - Tibial51.69 - Artery - Coronary32.38 - Nerve - Tibial31.05 - Brain - Spinal cord (cervical c-1)28.63 - Artery - Aorta28.08 - Adipose - Subcutaneous26.26 - Uterus26.19 - Cervix - Ectocervix25.85 - Testis25.57 - Brain - Cerebellum24.33 - Cervix - Endocervix23.92 - Brain - Cerebellar Hemisphere23.82 - Thyroid23.61 - Lung22.44 - Breast - Mammary Tissue22.25 - Brain - Frontal Cortex (BA9)21.4 - Fallopian Tube21.03 - Brain - Cortex20.88 - Ovary20.54 - Brain - Hippocampus20.49 - Colon - Sigmoid20.3 - Bladder19.93 - Adrenal Gland19.54 - Prostate19.45 - Adipose - Visceral (Omentum)18.87 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (37) - GO:0001525 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001525) - GO:0001890 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001890) - GO:0003007 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003007) - GO:0007179 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007179) - GO:0007229 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007229) - GO:0007411 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007411) - GO:0008360 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008360) - GO:0010594 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010594) - GO:0010632 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010632) - GO:0010634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010634) - GO:0010718 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010718) - GO:0010759 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010759) - GO:0010763 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010763) - GO:0016477 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016477) - GO:0022408 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022408) - GO:0030010 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030010) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0033629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033629) - GO:0033634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033634) - GO:0035995 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035995) - GO:0038007 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038007) - GO:0038096 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038096) - GO:0042127 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042127) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0045667 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045667) And 12 more, listed on the interactive page. ### Cellular components (7) - GO:0001725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001725) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005856 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005856) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0036064 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036064) ### Molecular functions (11) - GO:0003779 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003779) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0004725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004725) - GO:0005178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005178) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008432 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008432) - GO:0019901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901) - GO:0019903 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019903) - GO:0042169 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042169) - GO:0140677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140677) ## On-target safety - abnormal platelet production and function ### Effects - Activation/Increase/Upregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - metabolism disorder ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - metabolic PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - cardiac arrhythmia ### Studies - cell-based: Listed among thirty kinases critical for cardiomyocyte function based on the following criteria: (1) pharmacological inhibition correlated with cardiomyocyte beat changes, (2) expression in both human-induced pluripotent stemcell-derived cardiomyocytes and adult heart tissue, and (3) effects on cardiomyocyte beating following single gene knockdown. ### Biological samples - cardiovascular system PubMed 28453775 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28453775/) - cardiac hypertrophy ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Tumour promotion: increased metabolism and increased cell migration/invasion ### Effects - Activation/Increase/Upregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - platelet overproduction ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - heart disease ### Studies - preclinical: Important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Antihypertrophic and antifibrotic in heart ### Biological samples - cardiovascular system PubMed 21283106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/) - QT prolongation ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - reduced platelet adhesion ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - skin fibrosis ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - skin PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - liver fibrosis ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - liver PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - reduced platelet aggregation ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Hypertension ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Related records ### Trials (145) - 5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours - A Dose Escalation Study to Assess Safety of GSK2256098 (FAK Inhibitor) in Combination With Trametinib (MEK Inhibitor) in Subjects With Advanced Solid Tumors - A Dose-Escalation Study of ENMD-2076 Administered Orally to Patients With Advanced Cancer - A Multi-center, Open-label Study of Oral ENMD-2076 for the Treatment of Patients With Advanced Fibrolamellar Carcinoma - A Phase 1 Dose Escalation Study of VS-5584 Administered in Combination With VS-6063, in Subjects With Relapsed Malignant Mesothelioma - [A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors](https://trialight.com/data/trial/a-phase-1-2-study-of-vs-7375-in-patients-with-kras-g12d-2a83cb8c-fe8d-4b5c-88de-0eebb2025cdc.md) - A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib - A Phase 3 Study of IN10018 in Combination With D-1553 Versus Standard Therapy for First Line Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation - A Phase I, Open-label Study of Absorption, Metabolism, and Excretion of Defactinib (VS-6063) in Healthy Male Subjects - A Phase Ib Study of JMKX001899 in Combination With Other Therapies in Advanced NSCLC Harboring KRAS G12C Mutation - A Retrospective Study of the Efficacy and Safety of Lolatinib in ALK+ NSCLC Patients With Brain or Meningeal Metastasis - A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer - A Study of Avutometinib (VS-6766) + Defactinib in Recurrent KRAS G12V, Other KRAS and BRAF Non-Small Cell Lung Cancer - A Study of Avutometinib (VS-6766) and Defactinib in People With Mesonephric Gynecologic Cancer - A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation - A Study of Avutometinib + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer in Japanese Patients - A Study of Avutometinib and Defactinib in People With Thyroid Cancer - A Study of Avutometinib, Defactinib, and Letrozole in People With Low-Grade Serous Ovarian Cancer - A Study of BI 853520 in Japanese and Taiwanese Patients With Various Types of Advanced or Metastatic Cancer - A Study of BI 853520 in Patients With Various Types of Advanced or Metastatic Cancer ### Drugs (11) - CEP-37440 Focal adhesion kinase 1 inhibitor - Conteltinib Focal adhesion kinase 1 inhibitor - [Defactinib](https://trialight.com/data/asset/defactinib-93d3f8e7-960f-4e54-9e6e-fd0a1504d053.md) Focal adhesion kinase 1 inhibitor - Defactinib hydrochloride Focal adhesion kinase 1 inhibitor - ENMD-2076 - GSK-2256098 Focal adhesion kinase 1 inhibitor - Ifebemtinib Focal adhesion kinase 1 inhibitor - Lorlatinib - Narmafotinib - PF-00562271 Focal adhesion kinase 1 inhibitor - VS-4718 Focal adhesion kinase 1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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