PTK2

ENSG00000169398
Target class
Kinase
Chromosome
8
Approved drugs
0
Clinical candidates (approved and in development)
7

Approved drugs
0
Clinical candidates (approved and in development)
7

Chemical probe available
Yes

Target name
PTK2
Gene name
Protein tyrosine kinase 2
Gene symbol
PTK2
Protein name
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)

  • FAK
  • FADK
  • FAK1
  • PPP1R71

Gene biotype
Protein coding
Gene family
Protein phosphatase 1 regulatory subunits|FERM domain containing|PTK2 family tyrosine kinases|MicroRNA protein coding host genes
Target class
Kinase
Target type
Human gene

Tissues expressed in
53
Protein localisation evidence grade
Supported
Highest tissue expression
51.69
Tissue specificity (Gini)
0.236
Tissue specificity (tau)
0.656

KEGG gene identifiers
  • hsa:5747
Protein interaction confidence
0.884782
Protein interaction partners
156

  • R-HSA-111465
  • R-HSA-2029482
  • R-HSA-354192
  • R-HSA-354194
  • R-HSA-372708
  • R-HSA-375165
  • R-HSA-391160
  • R-HSA-3928662
  • R-HSA-418885
  • R-HSA-4420097
  • R-HSA-5663213
  • R-HSA-5673001
  • R-HSA-8874081
  • R-HSA-9009391
  • R-HSA-9634638
  • R-HSA-9664422
  • R-HSA-9860927

End position
141002216
Start position
140657900
Chromosome
8
Strand
Reverse

Ensembl gene ID
ENSG00000169398
HGNC ID
HGNC:9611
www.genenames.org
NCBI Gene ID
5747
UniProt ID
Q05397

  • Cell junction, focal adhesion . Cell membrane
  • Peripheral membrane protein
  • Cytoplasmic side . Cytoplasm, perinuclear region . Cytoplasm, cell cortex. Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm . Note=Constituent of focal adhesions. Detected at microtubules. .
  • Cytosol
  • Focal adhesion sites

Tissue specificity (tau)
0.655552
Expression inequality (Gini)
0.235848

Expression in transcripts per million

Artery - Tibial
51.69
Artery - Coronary
32.38
Nerve - Tibial
31.05
Brain - Spinal cord (cervical c-1)
28.63
Artery - Aorta
28.08

Expression in transcripts per million

  • Artery - Tibial51.69
  • Artery - Coronary32.38
  • Nerve - Tibial31.05
  • Brain - Spinal cord (cervical c-1)28.63
  • Artery - Aorta28.08
  • Adipose - Subcutaneous26.26
  • Uterus26.19
  • Cervix - Ectocervix25.85
  • Testis25.57
  • Brain - Cerebellum24.33
  • Cervix - Endocervix23.92
  • Brain - Cerebellar Hemisphere23.82
  • Thyroid23.61
  • Lung22.44
  • Breast - Mammary Tissue22.25
  • Brain - Frontal Cortex (BA9)21.4
  • Fallopian Tube21.03
  • Brain - Cortex20.88
  • Ovary20.54
  • Brain - Hippocampus20.49
  • Colon - Sigmoid20.3
  • Bladder19.93
  • Adrenal Gland19.54
  • Prostate19.45
  • Adipose - Visceral (Omentum)18.87

And 29 more, listed on the interactive page.

And 12 more, listed on the interactive page.

  • abnormal platelet production and function

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • metabolism disorder

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • metabolic
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • cardiac arrhythmia

    Studies

    • cell-based: Listed among thirty kinases critical for cardiomyocyte function based on the following criteria: (1) pharmacological inhibition correlated with cardiomyocyte beat changes, (2) expression in both human-induced pluripotent stemcell-derived cardiomyocytes and adult heart tissue, and (3) effects on cardiomyocyte beating following single gene knockdown.

    Biological samples

    • cardiovascular system
    PubMed 28453775
    pubmed.ncbi.nlm.nih.gov

  • cardiac hypertrophy

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • CV
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • Tumour promotion: increased metabolism and increased cell migration/invasion

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • platelet overproduction

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • heart disease

    Studies

    • preclinical: Important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Antihypertrophic and antifibrotic in heart

    Biological samples

    • cardiovascular system
    PubMed 21283106
    pubmed.ncbi.nlm.nih.gov

  • QT prolongation

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • CV
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • reduced platelet adhesion

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • skin fibrosis

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical

    Biological samples

    • skin
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • liver fibrosis

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical

    Biological samples

    • liver
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • reduced platelet aggregation

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • Hypertension

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • CV
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

Related records

Trials (145)

Drugs (11)