PTGS2
ENSG00000073756
Target class
Enzyme
Chromosome
1
Approved drugs
59
Clinical candidates (approved and in development)
73
- Approved drugs
- 59
- Clinical candidates (approved and in development)
- 73
- Chemical probe available
- Yes
- Other names
- COX2
- Target name
- PTGS2
- Gene name
- Prostaglandin-endoperoxide synthase 2
- Gene symbol
- PTGS2
- Protein name
- Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2)
- Gene biotype
- Protein coding
- Gene family
- Prostaglandin-endoperoxide synthase family
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 43
- Protein localisation evidence grade
- Supported
- Highest tissue expression
- 21.88
- Tissue specificity (Gini)
- 0.561
- Tissue specificity (tau)
- 0.856
- KEGG gene identifiers
- hsa:5743
- Protein interaction confidence
- 0.828317
- Protein interaction partners
- 104
- R-HSA-2142770
- R-HSA-2162123
- R-HSA-6783783
- R-HSA-6785807
- R-HSA-9018677
- R-HSA-9018679
- R-HSA-9025094
- R-HSA-9027604
- End position
- 186680922
- Start position
- 186671791
- Chromosome
- 1
- Strand
- Reverse
- Microsome membrane
- Peripheral membrane protein. Endoplasmic reticulum membrane
- Peripheral membrane protein. Nucleus inner membrane
- Peripheral membrane protein. Nucleus outer membrane
- Peripheral membrane protein. Note=Detected on the lumenal side of the endoplasmic reticulum and nuclear envelope. .
- Cytosol
- Vesicles
Publication evidence
- PubMed 9545330
- Tissue specificity (tau)
- 0.855731
- Expression inequality (Gini)
- 0.560943
Expression in transcripts per million
- Lung
- 21.88
- Colon - Sigmoid
- 15.47
- Prostate
- 14.49
- Kidney - Medulla
- 13.15
- Bladder
- 11.92
Expression in transcripts per million
- Lung21.88
- Colon - Sigmoid15.47
- Prostate14.49
- Kidney - Medulla13.15
- Bladder11.92
- Adipose - Visceral (Omentum)7.99
- Artery - Coronary7.23
- Artery - Tibial6.94
- Artery - Aorta6.91
- Colon - Transverse5.42
- Heart - Atrial Appendage4.97
- Esophagus - Gastroesophageal Junction4.86
- Whole Blood4.39
- Pituitary4.35
- Fallopian Tube4.18
- Esophagus - Muscularis3.63
- Brain - Spinal cord (cervical c-1)2.94
- Vagina2.68
- Kidney - Cortex2.67
- Cells - Cultured fibroblasts2.47
- Cervix - Endocervix2.43
- Stomach2.42
- Brain - Frontal Cortex (BA9)2.11
- Thyroid2.06
- Adipose - Subcutaneous1.85
And 29 more, listed on the interactive page.
- GO:0001516
- GO:0019371
- GO:0019372
- GO:0042759
- GO:0071456
- GO:0005637
- GO:0005640
- GO:0005737
- GO:0005783
- GO:0005788
- GO:0005789
- GO:0043005
- GO:0004666
- GO:0005515
- GO:0016701
- GO:0019899
Decrease, Population growth rate
Effects
- Inhibition/Decrease/Downregulation
Studies
- cell-based
Evidence sourceReduced, Reproductive Success
Effects
- Inhibition/Decrease/Downregulation
Studies
- cell-based
Evidence sourcedecreased mitosis
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: decreased mitosis
- renal
- immune
- cardiovascular
PubMed 28216264decreased pain
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: decreased pain
- renal
- immune
- cardiovascular
PubMed 28216264Reduced, Reproductive Success
Effects
- Inhibition/Decrease/Downregulation
Studies
- cell-based
Evidence sourceinhibits some mitogenic actions
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- clinical: inhibits some mitogenic actions
Biological samples
- cardiovascular system
Evidence sourceclotting
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- clinical: clotting
Biological samples
- cardiovascular system
Evidence sourceantiinflammatory
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- clinical: antiinflammatory
Biological samples
- cardiovascular system
Evidence sourcedecreased urinary sodium excretion
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: decreased urinary sodium excretion
- renal
- immune
- cardiovascular
PubMed 28216264Reduced, Reproductive Success
Effects
- Inhibition/Decrease/Downregulation
Studies
- cell-based
Evidence sourceincreased risk of wound infections
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- clinical: increased risk of wound infections
Biological samples
- cardiovascular system
Evidence sourcecerebrovascular events
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- clinical: cerebrovascular events
Biological samples
- cardiovascular system
Evidence sourceDecrease, Population growth rate
Effects
- Inhibition/Decrease/Downregulation
Studies
- cell-based
Evidence sourceDecrease, Population growth rate
Effects
- Inhibition/Decrease/Downregulation
Studies
- cell-based
Evidence sourceheart attack
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: heart attack
- renal
- immune
- cardiovascular
PubMed 28216264myocardial infarction
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- clinical: myocardial infarction
Biological samples
- cardiovascular system
Evidence sourceN/A, Reproductive failure
Effects
- Inhibition/Decrease/Downregulation
Studies
- cell-based
Evidence sourceischemic stroke
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: ischemic stroke
- renal
- immune
- cardiovascular
PubMed 28216264heart failure
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- clinical: heart failure
Biological samples
- cardiovascular system
Evidence sourceReduced, Reproductive Success
Effects
- Inhibition/Decrease/Downregulation
Studies
- cell-based
Evidence sourceincreased blood pressure
Effects
- Inhibition/Decrease/Downregulation: chronic
Studies
- preclinical: increased blood pressure
- renal
- immune
- cardiovascular
PubMed 28216264decreased urinary potassium excretion
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: decreased urinary potassium excretion
- renal
- immune
- cardiovascular
PubMed 28216264decreased inflammation
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: decreased inflammation
- renal
- immune
- cardiovascular
PubMed 28216264atherothrombosis
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: atherothrombosis
- renal
- immune
- cardiovascular
PubMed 28216264hypotension
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- clinical: hypotension
Biological samples
- cardiovascular system
Evidence source
And 6 more, listed on the interactive page.
anti-inflammatory activity
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- preclinical: anti-inflammatory activity
- cardiovascular system
- Immune
PubMed 23197038atherothrombosis
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- preclinical: atherothrombosis
- cardiovascular system
- Immune
PubMed 23197038myocardial infarction
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- preclinical: myocardial infarction
- cardiovascular system
- Immune
PubMed 23197038increased blood pressure
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- preclinical: increased blood pressure
- cardiovascular system
- Immune
PubMed 23197038anti-mitogenic effects
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- preclinical: anti-mitogenic effects
- cardiovascular system
- Immune
PubMed 23197038ischaemic stroke
Effects
- Inhibition/Decrease/Downregulation: general
Studies
- preclinical: ischaemic stroke
- cardiovascular system
- Immune
PubMed 23197038
Related records
Trials (7,057)
- "A Prospective Study of the Efficacy of Intracameral Dexamethasone (Dexycu™) Compared to Standard of Care Treatment for Post-Cataract Surgical Pain and Anterior Chamber Inflammation"
- "Management of Low Back Pain in the Emergency Department With Different Analgesic Dosages"
- "Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up
- "NSAIDs in Acute Achilles Tendinopathy: Effect on Pain Control, Leg Stiffness and Functional Recovery in Athletes"
- "NSAIDs vs. Opiates: Which is More Effective in Managing Pain in Mild to Moderate Acute Pancreatitis?
- "Postoperative Pain Following Laser-Assisted Root Canal Treatment: A Randomized Clinical Trial"
- "Supracondylar Radial Nerve Block Guided by Ultrasound Versus Hematoma Block for Analgesic Management in Closed Reduction of Distal Radius Fractures"
- "THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"
- (CB-01-02/01) Randomized Placebo Controlled Trial of Budesonide-multi-matrix System (MMX™) 6 mg and 9 mg in Patients With Ulcerative Colitis
- [SOCRATES -Acute Stroke Or Transient IsChaemic Attack TReated With Aspirin or Ticagrelor and Patient OutcomES]
- 0822GCC: Phase 2 Study of Efficacy and Safety of Apricoxib/Placebo With Docetaxel or Pemetrexed in Non-Small Cell Lung Cancer
- 1-month DAPT Plus 5-month Ticagrelor Monotherapy Versus 12-month DAPT in Patients With Drug-coated Balloon
- 1.Comparison of the Analgesic Effect of Remifentanil Group and Different Dose Groups of Oliceridine in Postoperative Patients Undergoing Cardiac Surgery 2.Exploring the Hemodynamic Effects of Analgesic Regimens With Different Doses of Oliceridine After Cardiac Surgery
- 14-day Double Therapy Versus Bismuth Quadruple Therapy in First-line Treatment of Helicobacter Pylori Infection
- 162 mg of Aspirin for Prevention of Preeclampsia
- 3 Anthracyclines, 2 Types of Consolidation With Different ARA-C Doses and Maintenance in Adult Acute Myeloid Leukemia
- 3 Months Versus 12 Months Dual Antiplatelet Therapy After Drug-eluting Stent Implantation in STEMI
- 3-Month Discontinuation of Dual Antiplatelet Therapy After Ultimaster Sirolimus-Eluting Stent Implantation
- 30-Day Trial of Oral Valtrex or Valtrex Plus Aspirin on Shedding of HSV DNA in Tears and Saliva of Volunteers
- 4-methylpyrazole and Acetaminophen Metabolism
Drugs (82)
- Aceclofenac Cyclooxygenase-2 inhibitor
- Acemetacin Cyclooxygenase inhibitor
- Acetaminophen Cyclooxygenase inhibitor
- Aloxiprin Cyclooxygenase inhibitor
- Apazone Cyclooxygenase inhibitor
- Apricoxib Cyclooxygenase-2 inhibitor
- Aspirin Cyclooxygenase inhibitor
- Balsalazide Cyclooxygenase inhibitor
- Balsalazide disodium Cyclooxygenase inhibitor
- Benzydamine Cyclooxygenase inhibitor
- Benzydamine hydrochloride Cyclooxygenase inhibitor
- Bismuth subsalicylate Cyclooxygenase inhibitor
- Bromfenac Cyclooxygenase inhibitor
- Bromfenac sodium Cyclooxygenase inhibitor
- Carprofen Cyclooxygenase-2 inhibitor
- Celecoxib Cyclooxygenase-2 inhibitor
- Cimicoxib Cyclooxygenase-2 inhibitor
- Clometacin Cyclooxygenase inhibitor
- Dexibuprofen Cyclooxygenase inhibitor
- Dexketoprofen Cyclooxygenase inhibitor