> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ptger4-9f54f68f-da8d-5c48-8282-f46107d5b5a3 > Record changed: 2026-11-04 # PTGER4 ENSG00000171522 Target class GPCR Chromosome 5 Approved drugs 1 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** Yes ## Names **Other names** - EP4 **Target name** PTGER4 **Gene name** Prostaglandin E receptor 4 **Gene symbol** PTGER4 **Protein name** Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) ## Classification **Gene biotype** Protein coding **Gene family** Prostaglandin receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 40 **Highest tissue expression** 24.39 **Tissue specificity (Gini)** 0.485 **Tissue specificity (tau)** 0.752 ## Pathways and interactions **KEGG gene identifiers** - hsa:5734 **Protein interaction confidence** 0.846087 **Protein interaction partners** 23 ### Reactome pathways (2) - R-HSA-391908 - R-HSA-418555 ## Genomic location **End position** 40693735 **Start position** 40679915 **Chromosome** 5 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000171522 **HGNC ID** HGNC:9596 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9596) **NCBI Gene ID** 5734 **UniProt ID** P35408 ## Cellular location - Cell membrane - Multi-pass membrane protein. ## Tissue expression **Tissue specificity (tau)** 0.752133 **Expression inequality (Gini)** 0.484776 ### Highest expression Expression in transcripts per million **Lung** 24.39 **Colon - Transverse** 17.81 **Small Intestine - Terminal Ileum** 16.93 **Adipose - Visceral (Omentum)** 16.8 **Colon - Sigmoid** 16.19 ### All tissues (54) Expression in transcripts per million - Lung24.39 - Colon - Transverse17.81 - Small Intestine - Terminal Ileum16.93 - Adipose - Visceral (Omentum)16.8 - Colon - Sigmoid16.19 - Adipose - Subcutaneous14.97 - Spleen14.54 - Fallopian Tube13.87 - Pancreas12.57 - Artery - Tibial11.85 - Nerve - Tibial11.83 - Breast - Mammary Tissue11.24 - Bladder10.3 - Kidney - Medulla10.04 - Stomach8.84 - Whole Blood8.79 - Kidney - Cortex7.43 - Artery - Coronary7.31 - Cervix - Endocervix7.14 - Thyroid6.67 - Esophagus - Gastroesophageal Junction6.53 - Skin - Not Sun Exposed (Suprapubic)6.24 - Skin - Sun Exposed (Lower leg)6.08 - Esophagus - Muscularis5.84 - Artery - Aorta5.78 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0006955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955) - GO:0007188 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007188) - GO:0007189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189) - GO:0007193 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007193) - GO:0009612 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009612) - GO:0033624 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033624) - GO:0034695 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034695) - GO:0050728 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050728) - GO:2000420 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000420) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (2) - GO:0004957 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004957) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (767) - 24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E - 24-Hour Vaginal Dinoprostone Pessary Versus Gel for Labour Induction - 400mcg Sublingual Misoprostol as First Line Treatment - A 48-week Study of the Effect of Dual Therapy (Inhaled Treprostinil and Tadafafil) Versus Monotherapy (Tadalafil). - A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension - A Clinical Study to Assess the Effect of Clopidogrel on the Pharmacokinetics of Selexipag and Its Active Metabolite in Healthy Male Subjects - A Clinical Study to Investigate the Effect of Gemfibrozil or Rifampicin on Blood Concentrations of Selexipag in Healthy Subjects - A Comparative Study Between Rectal and Intrauterine Misoprostol Administration in the Reduction of Blood Loss During and After Elective Cesarean Delivery in Low Risk Women - A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor - A Comparison of Sublingual and Buccal Misoprostol Regimens After Mifepristone for Mid-trimester Abortion - A Multicenter, Double Blinded, Randomized, Parallel Assignment Study to Demonstrate the Efficacy of DA9601 - A Novel Protocol for Labour Induction - A Pharmacokinetic Study of TRK-100STP in Japanese Patients With Renal Impairment - A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD) - A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD - A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD - A Pilot of an Outpatient Regimen of Medical Abortion With Mifepristone and Sublingual Misoprostol in the 11 and 12 Weeks - A Pilot Study of Priming Before Induction Termination of Pregnancy - A Prospective Randomized Comparison Trial on the Use of Mifepristone With Sublingual or Buccal Misoprostol for Medical Abortions of Less Than 9 Weeks Gestation - A Prospective Study of Misoprostol Administration in Asymptomatic Patients With Pregnancies of Unknown Location ### Drugs (19) - Alprostadil - Beraprost - Cicaprost - Dinoprost - Dinoprostone Prostaglandin E2 receptor agonist - Enprostil - Epoprostenol - Evatanepag - Grapiprant Prostanoid EP4 receptor antagonist - Iloprost - Laselipag - Misoprostol - Misoprostol acid - Palupiprant - Rivenprost Prostanoid EP4 receptor agonist - Selexipag - [Treprostinil](https://trialight.com/data/asset/treprostinil-002fe1ce-a63f-4f2b-9562-6cbff048a970.md) - Vorbipiprant Prostanoid EP4 receptor antagonist - Vorbipiprant sodium Prostanoid EP4 receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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