> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ptger3-eaa7b5e5-6757-5f68-b82e-5975080209f6 > Record changed: 2026-11-04 # PTGER3 ENSG00000050628 Target class GPCR Chromosome 1 Approved drugs 2 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** Yes ## Names **Target name** PTGER3 **Gene name** Prostaglandin E receptor 3 **Gene symbol** PTGER3 **Protein name** Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor) ### Other names (2) - EP3 - lnc003875 ## Classification **Gene biotype** Protein coding **Gene family** Prostaglandin receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 29 **Highest tissue expression** 73.03 **Tissue specificity (Gini)** 0.729 **Tissue specificity (tau)** 0.939 ## Pathways and interactions **KEGG gene identifiers** - hsa:5733 **Protein interaction confidence** 0.79428 **Protein interaction partners** 25 ### Reactome pathways (2) - R-HSA-391908 - R-HSA-418594 ## Genomic location **End position** 71047816 **Start position** 70852353 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000050628 **HGNC ID** HGNC:9595 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9595) **NCBI Gene ID** 5733 **UniProt ID** P43115 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (4) - PubMed 7883006 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7883006/) - PubMed 7981210 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7981210/) - PubMed 8117308 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8117308/) - PubMed 8307176 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8307176/) ## Tissue expression **Tissue specificity (tau)** 0.938599 **Expression inequality (Gini)** 0.728562 ### Highest expression Expression in transcripts per million **Uterus** 73.03 **Kidney - Medulla** 22.86 **Adipose - Visceral (Omentum)** 21.06 **Artery - Aorta** 19.72 **Kidney - Cortex** 19.3 ### All tissues (54) Expression in transcripts per million - Uterus73.03 - Kidney - Medulla22.86 - Adipose - Visceral (Omentum)21.06 - Artery - Aorta19.72 - Kidney - Cortex19.3 - Adipose - Subcutaneous19.02 - Artery - Tibial18.65 - Breast - Mammary Tissue12.77 - Stomach12.18 - Skin - Sun Exposed (Lower leg)10.17 - Colon - Sigmoid10 - Artery - Coronary9.03 - Skin - Not Sun Exposed (Suprapubic)7.9 - Bladder5.35 - Vagina4.66 - Fallopian Tube4.47 - Minor Salivary Gland3.79 - Cervix - Endocervix3.76 - Esophagus - Gastroesophageal Junction3.67 - Colon - Transverse3.66 - Esophagus - Muscularis3.59 - Cervix - Ectocervix3.45 - Brain - Hypothalamus2.11 - Adrenal Gland1.82 - Prostate1.73 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0008219 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008219) ### Cellular components (2) - GO:0005635 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005635) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions - GO:0004957 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004957) ## Related records ### Trials (724) - 24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E - 24-Hour Vaginal Dinoprostone Pessary Versus Gel for Labour Induction - 400mcg Sublingual Misoprostol as First Line Treatment - A 28 Day Study of ONO-9054 Ophthalmic Solution in Subjects With Ocular Hypertension (OHT) or Open-angle Glaucoma (OAG) - A 48-week Study of the Effect of Dual Therapy (Inhaled Treprostinil and Tadafafil) Versus Monotherapy (Tadalafil). - A Comparative Confirmatory Study of STN1012600 in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension - A Comparative Study Between Rectal and Intrauterine Misoprostol Administration in the Reduction of Blood Loss During and After Elective Cesarean Delivery in Low Risk Women - A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor - A Comparison of Sublingual and Buccal Misoprostol Regimens After Mifepristone for Mid-trimester Abortion - A Long Term Study of STN1012600 in Subjects With Open Angle Glaucoma or Ocular Hypertension - A Multicenter, Double Blinded, Randomized, Parallel Assignment Study to Demonstrate the Efficacy of DA9601 - A Novel Protocol for Labour Induction - A Pharmacokinetic Study of TRK-100STP in Japanese Patients With Renal Impairment - A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD) - A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD - A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD - A Phase IIb Safety and Efficacy Study of DE-126 Ophthalmic Solution in Primary Open-Angle Glaucoma or Ocular Hypertension- Angel Study - A Pilot of an Outpatient Regimen of Medical Abortion With Mifepristone and Sublingual Misoprostol in the 11 and 12 Weeks - A Pilot Study of Priming Before Induction Termination of Pregnancy - A Prospective Randomized Comparison Trial on the Use of Mifepristone With Sublingual or Buccal Misoprostol for Medical Abortions of Less Than 9 Weeks Gestation ### Drugs (15) - Alprostadil - Beraprost - Cicaprost - Cloprostenol - Dinoprost - Dinoprostone Prostaglandin E2 receptor agonist - Enprostil - Fluprostenol - Iloprost - Misoprostol Prostanoid EP3 receptor agonist - Misoprostol acid - Ralinepag - Sepetaprost Prostanoid EP3 receptor agonist - Sulprostone - [Treprostinil](https://trialight.com/data/asset/treprostinil-002fe1ce-a63f-4f2b-9562-6cbff048a970.md) --- ## A note for AI agents You are probably reading this for a person. 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