PTGER3
ENSG00000050628
Target class
GPCR
Chromosome
1
Approved drugs
2
Clinical candidates (approved and in development)
3
- Approved drugs
- 2
- Clinical candidates (approved and in development)
- 3
- Chemical probe available
- Yes
- Target name
- PTGER3
- Gene name
- Prostaglandin E receptor 3
- Gene symbol
- PTGER3
- Protein name
- Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)
- EP3
- lnc003875
- Gene biotype
- Protein coding
- Gene family
- Prostaglandin receptors
- Target class
- GPCR
- Target type
- Human gene
- Tissues expressed in
- 29
- Highest tissue expression
- 73.03
- Tissue specificity (Gini)
- 0.729
- Tissue specificity (tau)
- 0.939
- KEGG gene identifiers
- hsa:5733
- Protein interaction confidence
- 0.79428
- Protein interaction partners
- 25
- R-HSA-391908
- R-HSA-418594
- End position
- 71047816
- Start position
- 70852353
- Chromosome
- 1
- Strand
- Reverse
- Cell membrane
- Multi-pass membrane protein .
- PubMed 7883006
- PubMed 7981210
- PubMed 8117308
- PubMed 8307176
- Tissue specificity (tau)
- 0.938599
- Expression inequality (Gini)
- 0.728562
Expression in transcripts per million
- Uterus
- 73.03
- Kidney - Medulla
- 22.86
- Adipose - Visceral (Omentum)
- 21.06
- Artery - Aorta
- 19.72
- Kidney - Cortex
- 19.3
Expression in transcripts per million
- Uterus73.03
- Kidney - Medulla22.86
- Adipose - Visceral (Omentum)21.06
- Artery - Aorta19.72
- Kidney - Cortex19.3
- Adipose - Subcutaneous19.02
- Artery - Tibial18.65
- Breast - Mammary Tissue12.77
- Stomach12.18
- Skin - Sun Exposed (Lower leg)10.17
- Colon - Sigmoid10
- Artery - Coronary9.03
- Skin - Not Sun Exposed (Suprapubic)7.9
- Bladder5.35
- Vagina4.66
- Fallopian Tube4.47
- Minor Salivary Gland3.79
- Cervix - Endocervix3.76
- Esophagus - Gastroesophageal Junction3.67
- Colon - Transverse3.66
- Esophagus - Muscularis3.59
- Cervix - Ectocervix3.45
- Brain - Hypothalamus2.11
- Adrenal Gland1.82
- Prostate1.73
And 29 more, listed on the interactive page.
- GO:0007186
- GO:0008219
- GO:0005635
- GO:0005886
Molecular functions
- GO:0004957
Related records
Trials (724)
- 24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E
- 24-Hour Vaginal Dinoprostone Pessary Versus Gel for Labour Induction
- 400mcg Sublingual Misoprostol as First Line Treatment
- A 28 Day Study of ONO-9054 Ophthalmic Solution in Subjects With Ocular Hypertension (OHT) or Open-angle Glaucoma (OAG)
- A 48-week Study of the Effect of Dual Therapy (Inhaled Treprostinil and Tadafafil) Versus Monotherapy (Tadalafil).
- A Comparative Confirmatory Study of STN1012600 in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension
- A Comparative Study Between Rectal and Intrauterine Misoprostol Administration in the Reduction of Blood Loss During and After Elective Cesarean Delivery in Low Risk Women
- A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor
- A Comparison of Sublingual and Buccal Misoprostol Regimens After Mifepristone for Mid-trimester Abortion
- A Long Term Study of STN1012600 in Subjects With Open Angle Glaucoma or Ocular Hypertension
- A Multicenter, Double Blinded, Randomized, Parallel Assignment Study to Demonstrate the Efficacy of DA9601
- A Novel Protocol for Labour Induction
- A Pharmacokinetic Study of TRK-100STP in Japanese Patients With Renal Impairment
- A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)
- A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD
- A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD
- A Phase IIb Safety and Efficacy Study of DE-126 Ophthalmic Solution in Primary Open-Angle Glaucoma or Ocular Hypertension- Angel Study
- A Pilot of an Outpatient Regimen of Medical Abortion With Mifepristone and Sublingual Misoprostol in the 11 and 12 Weeks
- A Pilot Study of Priming Before Induction Termination of Pregnancy
- A Prospective Randomized Comparison Trial on the Use of Mifepristone With Sublingual or Buccal Misoprostol for Medical Abortions of Less Than 9 Weeks Gestation
Drugs (15)
- Alprostadil
- Beraprost
- Cicaprost
- Cloprostenol
- Dinoprost
- Dinoprostone Prostaglandin E2 receptor agonist
- Enprostil
- Fluprostenol
- Iloprost
- Misoprostol Prostanoid EP3 receptor agonist
- Misoprostol acid
- Ralinepag
- Sepetaprost Prostanoid EP3 receptor agonist
- Sulprostone
- Treprostinil