> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ptger2-cb9b3c14-5b7f-5eb3-963b-5a2c095b85d1 > Record changed: 2026-11-04 # PTGER2 ENSG00000125384 Target class GPCR Chromosome 14 Approved drugs 3 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** Yes ## Names **Target name** PTGER2 **Gene name** Prostaglandin E receptor 2 **Gene symbol** PTGER2 **Protein name** Prostaglandin E2 receptor EP2 subtype (PGE receptor EP2 subtype) (PGE2 receptor EP2 subtype) (Prostanoid EP2 receptor) ### Other names (2) - EP2 - COX-2 ## Classification **Gene biotype** Protein coding **Gene family** Prostaglandin receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 35 **Highest tissue expression** 54.87 **Tissue specificity (Gini)** 0.68 **Tissue specificity (tau)** 0.909 ## Pathways and interactions **KEGG gene identifiers** - hsa:5732 **Protein interaction confidence** 0.853286 **Protein interaction partners** 21 ### Reactome pathways (2) - R-HSA-391908 - R-HSA-418555 ## Genomic location **End position** 52329822 **Start position** 52314305 **Chromosome** 14 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000125384 **HGNC ID** HGNC:9594 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9594) **NCBI Gene ID** 5732 **UniProt ID** P43116 ## Cellular location - Cell membrane - Multi-pass membrane protein. ## Tissue expression **Tissue specificity (tau)** 0.908786 **Expression inequality (Gini)** 0.680209 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 54.87 **Cervix - Endocervix** 34.01 **Whole Blood** 24.65 **Spleen** 19.73 **Cervix - Ectocervix** 18.88 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts54.87 - Cervix - Endocervix34.01 - Whole Blood24.65 - Spleen19.73 - Cervix - Ectocervix18.88 - Uterus15.41 - Prostate13.59 - Small Intestine - Terminal Ileum12.88 - Ovary11.91 - Adipose - Visceral (Omentum)10.83 - Lung10.46 - Stomach9.78 - Adipose - Subcutaneous7.19 - Colon - Transverse6.86 - Fallopian Tube5.34 - Nerve - Tibial5.33 - Kidney - Medulla5.18 - Breast - Mammary Tissue4.9 - Bladder4.33 - Esophagus - Gastroesophageal Junction4.06 - Minor Salivary Gland3.94 - Thyroid3.6 - Testis3.58 - Vagina3.51 - Esophagus - Muscularis3.16 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions - GO:0004957 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004957) ## On-target safety - increased/decreased inflammation ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased/decreased inflammation ### Biological samples (2) - urogenital - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased uterine motility ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased uterine motility ### Biological samples (2) - urogenital - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased/increased inflammation ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased/increased inflammation ### Biological samples (2) - urogenital - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Off-target safety - regulation of gene expression ### Studies - cell-based: BSK\_LPS\_PGE2, is one of 11 assay component(s) measured or calculated from the BSK\_LPS assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with fluorescence intensity signals by Enzyme-linked immunosorbent assay technology. ### Biological samples - umbilical vein endothelium and peripheral blood mononuclear cells, primary cell co-culture Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (749) - 24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E - 24-Hour Vaginal Dinoprostone Pessary Versus Gel for Labour Induction - 400mcg Sublingual Misoprostol as First Line Treatment - A 48-week Study of the Effect of Dual Therapy (Inhaled Treprostinil and Tadafafil) Versus Monotherapy (Tadalafil). - A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension - A Clinical Study to Assess the Effect of Clopidogrel on the Pharmacokinetics of Selexipag and Its Active Metabolite in Healthy Male Subjects - A Clinical Study to Investigate the Effect of Gemfibrozil or Rifampicin on Blood Concentrations of Selexipag in Healthy Subjects - A Comparative Study Between Rectal and Intrauterine Misoprostol Administration in the Reduction of Blood Loss During and After Elective Cesarean Delivery in Low Risk Women - A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor - A Comparison of Sublingual and Buccal Misoprostol Regimens After Mifepristone for Mid-trimester Abortion - A Long-term Study of DE-117 Ophthalmic Solution Monotherapy and Concomitant Use of DE-117 Ophthalmic Solution With Timolol Ophthalmic Solution in Patients With OAG or OH: RENGE Study - A Multicenter, Double Blinded, Randomized, Parallel Assignment Study to Demonstrate the Efficacy of DA9601 - A Novel Protocol for Labour Induction - A Pharmacokinetic Study of DE-117 Ophthalmic Solution in Healthy Adult Male Subjects - Phase I Study - - A Phase 2 Study Of The 24-Hour Intraocular Pressure Lowering And Systemic Exposure Of PF-04217329 - A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD) - A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD - A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD - A Phase III Study Assessing the Efficacy and Safety of DE-117 Ophthalmic Solution Compared With Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Glaucoma or Ocular Hypertension - Spectrum 3 Study - A Phase III Study Assessing the Efficacy and Safety of DE-117 Ophthalmic Solution Compared With Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Glaucoma or Ocular Hypertension - Spectrum 4 Study ### Drugs (18) - Alprostadil Prostanoid EP2 receptor agonist - Dinoprost - Dinoprostone Prostaglandin E2 receptor agonist - Evatanepag Prostanoid EP2 receptor agonist - Evatanepag sodium Prostanoid EP2 receptor agonist - Iloprost - Laselipag - Misoprostol - Misoprostol acid - Omidenepag Prostanoid EP2 receptor agonist - Omidenepag isopropyl Prostanoid EP2 receptor agonist - PF-04418948 - Rioprostil - Selexipag - Simenepag isopropyl Prostanoid EP2 receptor agonist - Taprenepag - Taprenepag isopropyl Prostanoid EP2 receptor agonist - [Treprostinil](https://trialight.com/data/asset/treprostinil-002fe1ce-a63f-4f2b-9562-6cbff048a970.md) --- ## A note for AI agents You are probably reading this for a person. 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