> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ptger1-bf966316-397d-594e-b09a-c53320112887 > Record changed: 2026-11-04 # PTGER1 ENSG00000160951 Target class GPCR Chromosome 19 Approved drugs 2 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** Yes ## Names **Other names** - EP1 **Target name** PTGER1 **Gene name** Prostaglandin E receptor 1 **Gene symbol** PTGER1 **Protein name** Prostaglandin E2 receptor EP1 subtype (PGE receptor EP1 subtype) (PGE2 receptor EP1 subtype) (Prostanoid EP1 receptor) ## Classification **Gene biotype** Protein coding **Gene family** Prostaglandin receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 15 **Highest tissue expression** 37.07 **Tissue specificity (Gini)** 0.72 **Tissue specificity (tau)** 0.971 ## Pathways and interactions **KEGG gene identifiers** - hsa:5731 **Protein interaction confidence** 0.815308 **Protein interaction partners** 13 ### Reactome pathways (2) - R-HSA-391908 - R-HSA-416476 ## Genomic location **End position** 14477272 **Start position** 14472466 **Chromosome** 19 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000160951 **HGNC ID** HGNC:9593 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9593) **NCBI Gene ID** 5731 **UniProt ID** P34995 ## Cellular location - Cell membrane - Multi-pass membrane protein. ## Tissue expression **Tissue specificity (tau)** 0.970988 **Expression inequality (Gini)** 0.719943 ### Highest expression Expression in transcripts per million **Kidney - Medulla** 37.07 **Spleen** 9.05 **Kidney - Cortex** 8.09 **Lung** 3.4 **Stomach** 3.28 ### All tissues (54) Expression in transcripts per million - Kidney - Medulla37.07 - Spleen9.05 - Kidney - Cortex8.09 - Lung3.4 - Stomach3.28 - Pituitary2.6 - Small Intestine - Terminal Ileum1.87 - Adrenal Gland1.76 - Fallopian Tube1.75 - Esophagus - Gastroesophageal Junction1.56 - Bladder1.38 - Artery - Coronary1.33 - Nerve - Tibial1.32 - Adipose - Visceral (Omentum)1.12 - Esophagus - Muscularis1.06 - Esophagus - Mucosa0.97 - Cervix - Endocervix0.96 - Thyroid0.83 - Prostate0.8 - Brain - Nucleus accumbens (basal ganglia)0.79 - Vagina0.75 - Uterus0.74 - Cells - Cultured fibroblasts0.71 - Breast - Mammary Tissue0.67 - Brain - Caudate (basal ganglia)0.63 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007200 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007200) - GO:0034695 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034695) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (2) - GO:0004957 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004957) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (312) - 24-Hour Vaginal Dinoprostone Pessary Versus Gel for Labour Induction - A 48-week Study of the Effect of Dual Therapy (Inhaled Treprostinil and Tadafafil) Versus Monotherapy (Tadalafil). - A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD) - A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD - A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD - A Randomised Trial Investigating the Efficacy and Safety of a Vaginal Insert in Pregnant Women at Term - A Safety/Efficacy Study of Alprostadil Liposomes for Injection to Treat Lower Extremity Arteriosclerosis Obliterans - A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension - A Study of Infusion Site Pain After Infusion of Excipients in Participants With Type 1 Diabetes Mellitus - A Study of Inhaled Treprostinil (LIQ861) in Adults With Pulmonary Arterial Hypertension Transitioning From Oral Selexipag - A Study of the Effect of ONO-8539 on Oesophageal Pain Hypersensitivity in Patients With Non-erosive Reflux Disease - A Study of Treprostinil and a New Formulation of LY900014 in Healthy Japanese Participants - A Study of Treprostinil to Treat Interstitial Lung Disease Pulmonary Hypertension - A Study to Assess the Safety and Efficacy of Treprostinil to Facilitate Liver Transplantation in Patients With Portopulmonary Hypertension - A Study to Evaluate Efficacy of 『Opast Tablet』for Neurologic Claudication in Patients With Lumbar Spinal Stenosis - A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of C16TR for Inhalation With Tyvaso® Cohort in Healthy Participants - A Study to Explore the Efficacy of Alprostadil Liposomes Injection in the Prevention of CI-AKI - A Study to Investigate the Effect of ONO-8539 on Acid-Induced Oesophageal Hypersensitivity in Healthy Volunteers - A Study to Observe the Safety, Tolerability, and Efficacy of Remodulin - A Trial of Cervidil for Outpatient Pre-induction of Cervical Ripening ### Drugs (13) - Alprostadil Prostanoid EP1 receptor agonist - Cicaprost - Cloprostenol - Dinoprost - Dinoprostone Prostaglandin E2 receptor agonist - Enprostil - Epoprostenol - Iloprost - Limaprost - ONO-8539 Prostanoid EP1 receptor antagonist - ONO-8711 - Sulprostone - [Treprostinil](https://trialight.com/data/asset/treprostinil-002fe1ce-a63f-4f2b-9562-6cbff048a970.md) --- ## A note for AI agents You are probably reading this for a person. 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