PTGER1
ENSG00000160951
Target class
GPCR
Chromosome
19
Approved drugs
2
Clinical candidates (approved and in development)
3
- Approved drugs
- 2
- Clinical candidates (approved and in development)
- 3
- Chemical probe available
- Yes
- Other names
- EP1
- Target name
- PTGER1
- Gene name
- Prostaglandin E receptor 1
- Gene symbol
- PTGER1
- Protein name
- Prostaglandin E2 receptor EP1 subtype (PGE receptor EP1 subtype) (PGE2 receptor EP1 subtype) (Prostanoid EP1 receptor)
- Gene biotype
- Protein coding
- Gene family
- Prostaglandin receptors
- Target class
- GPCR
- Target type
- Human gene
- Tissues expressed in
- 15
- Highest tissue expression
- 37.07
- Tissue specificity (Gini)
- 0.72
- Tissue specificity (tau)
- 0.971
- KEGG gene identifiers
- hsa:5731
- Protein interaction confidence
- 0.815308
- Protein interaction partners
- 13
- R-HSA-391908
- R-HSA-416476
- End position
- 14477272
- Start position
- 14472466
- Chromosome
- 19
- Strand
- Reverse
- Cell membrane
- Multi-pass membrane protein.
- Tissue specificity (tau)
- 0.970988
- Expression inequality (Gini)
- 0.719943
Expression in transcripts per million
- Kidney - Medulla
- 37.07
- Spleen
- 9.05
- Kidney - Cortex
- 8.09
- Lung
- 3.4
- Stomach
- 3.28
Expression in transcripts per million
- Kidney - Medulla37.07
- Spleen9.05
- Kidney - Cortex8.09
- Lung3.4
- Stomach3.28
- Pituitary2.6
- Small Intestine - Terminal Ileum1.87
- Adrenal Gland1.76
- Fallopian Tube1.75
- Esophagus - Gastroesophageal Junction1.56
- Bladder1.38
- Artery - Coronary1.33
- Nerve - Tibial1.32
- Adipose - Visceral (Omentum)1.12
- Esophagus - Muscularis1.06
- Esophagus - Mucosa0.97
- Cervix - Endocervix0.96
- Thyroid0.83
- Prostate0.8
- Brain - Nucleus accumbens (basal ganglia)0.79
- Vagina0.75
- Uterus0.74
- Cells - Cultured fibroblasts0.71
- Breast - Mammary Tissue0.67
- Brain - Caudate (basal ganglia)0.63
And 29 more, listed on the interactive page.
- GO:0007186
- GO:0007200
- GO:0034695
Cellular components
- GO:0005886
- GO:0004957
- GO:0005515
Related records
Trials (312)
- 24-Hour Vaginal Dinoprostone Pessary Versus Gel for Labour Induction
- A 48-week Study of the Effect of Dual Therapy (Inhaled Treprostinil and Tadafafil) Versus Monotherapy (Tadalafil).
- A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)
- A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD
- A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD
- A Randomised Trial Investigating the Efficacy and Safety of a Vaginal Insert in Pregnant Women at Term
- A Safety/Efficacy Study of Alprostadil Liposomes for Injection to Treat Lower Extremity Arteriosclerosis Obliterans
- A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension
- A Study of Infusion Site Pain After Infusion of Excipients in Participants With Type 1 Diabetes Mellitus
- A Study of Inhaled Treprostinil (LIQ861) in Adults With Pulmonary Arterial Hypertension Transitioning From Oral Selexipag
- A Study of the Effect of ONO-8539 on Oesophageal Pain Hypersensitivity in Patients With Non-erosive Reflux Disease
- A Study of Treprostinil and a New Formulation of LY900014 in Healthy Japanese Participants
- A Study of Treprostinil to Treat Interstitial Lung Disease Pulmonary Hypertension
- A Study to Assess the Safety and Efficacy of Treprostinil to Facilitate Liver Transplantation in Patients With Portopulmonary Hypertension
- A Study to Evaluate Efficacy of 『Opast Tablet』for Neurologic Claudication in Patients With Lumbar Spinal Stenosis
- A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of C16TR for Inhalation With Tyvaso® Cohort in Healthy Participants
- A Study to Explore the Efficacy of Alprostadil Liposomes Injection in the Prevention of CI-AKI
- A Study to Investigate the Effect of ONO-8539 on Acid-Induced Oesophageal Hypersensitivity in Healthy Volunteers
- A Study to Observe the Safety, Tolerability, and Efficacy of Remodulin
- A Trial of Cervidil for Outpatient Pre-induction of Cervical Ripening
Drugs (13)
- Alprostadil Prostanoid EP1 receptor agonist
- Cicaprost
- Cloprostenol
- Dinoprost
- Dinoprostone Prostaglandin E2 receptor agonist
- Enprostil
- Epoprostenol
- Iloprost
- Limaprost
- ONO-8539 Prostanoid EP1 receptor antagonist
- ONO-8711
- Sulprostone
- Treprostinil