> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ptgdr-e1fcfe16-9707-5c06-8ea9-af422cd94cd4 > Record changed: 2026-11-04 # PTGDR ENSG00000168229 Target class GPCR Chromosome 14 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** Yes ## Names **Target name** PTGDR **Gene name** Prostaglandin D2 receptor **Gene symbol** PTGDR **Protein name** Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor) ### Other names (3) - DP - DP1 - PTGDR1 ## Classification **Gene biotype** Protein coding **Gene family** Prostaglandin receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 20 **Protein localisation evidence grade** Approved **Highest tissue expression** 8.18 **Tissue specificity (Gini)** 0.582 **Tissue specificity (tau)** 0.852 ## Pathways and interactions **KEGG gene identifiers** - hsa:5729 **Protein interaction confidence** 0.804167 **Protein interaction partners** 6 ### Reactome pathways (2) - R-HSA-391908 - R-HSA-418555 ## Genomic location **End position** 52276724 **Start position** 52267698 **Chromosome** 14 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000168229 **HGNC ID** HGNC:9591 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9591) **NCBI Gene ID** 5729 **UniProt ID** Q13258 ## Cellular location - Cell membrane - Multi-pass membrane protein . - Cytosol - Plasma membrane ## Tissue expression **Tissue specificity (tau)** 0.851917 **Expression inequality (Gini)** 0.581944 ### Highest expression Expression in transcripts per million **Spleen** 8.18 **Colon - Transverse** 6.68 **Cervix - Ectocervix** 4.84 **Nerve - Tibial** 4.18 **Cervix - Endocervix** 4.1 ### All tissues (54) Expression in transcripts per million - Spleen8.18 - Colon - Transverse6.68 - Cervix - Ectocervix4.84 - Nerve - Tibial4.18 - Cervix - Endocervix4.1 - Fallopian Tube3.26 - Adipose - Subcutaneous3.19 - Lung2.89 - Uterus2.62 - Whole Blood2.24 - Thyroid2.24 - Breast - Mammary Tissue1.86 - Vagina1.85 - Adipose - Visceral (Omentum)1.8 - Small Intestine - Terminal Ileum1.73 - Artery - Coronary1.55 - Pituitary1.53 - Prostate1.4 - Bladder1.24 - Artery - Tibial1.16 - Ovary0.94 - Skin - Sun Exposed (Lower leg)0.94 - Esophagus - Gastroesophageal Junction0.92 - Artery - Aorta0.89 - Heart - Left Ventricle0.89 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0071799 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071799) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (326) - 24-Hour Vaginal Dinoprostone Pessary Versus Gel for Labour Induction - A 48-week Study of the Effect of Dual Therapy (Inhaled Treprostinil and Tadafafil) Versus Monotherapy (Tadalafil). - A Long-term Study of ERN/LRPT (Extended Release Niacin/Laropiprant \[MK0524A\]) in Patients With Dyslipidemia (0524A-102) - A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD) - A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD - A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD - A Randomised Trial Investigating the Efficacy and Safety of a Vaginal Insert in Pregnant Women at Term - A Safety/Efficacy Study of Alprostadil Liposomes for Injection to Treat Lower Extremity Arteriosclerosis Obliterans - A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension - A Study of Infusion Site Pain After Infusion of Excipients in Participants With Type 1 Diabetes Mellitus - A Study of Inhaled Treprostinil (LIQ861) in Adults With Pulmonary Arterial Hypertension Transitioning From Oral Selexipag - A Study of Laropiprant (MK-0524) in Participants With Moderate to Severe Erythematotelangiectatic Rosacea (MK-0524-155) - A Study of Treprostinil and a New Formulation of LY900014 in Healthy Japanese Participants - A Study of Treprostinil to Treat Interstitial Lung Disease Pulmonary Hypertension - A Study to Assess the Safety and Efficacy of Treprostinil to Facilitate Liver Transplantation in Patients With Portopulmonary Hypertension - A Study to Evaluate Efficacy and Safety of Extended-Release Niacin + Laropiprant + Simvastatin in Participants With Primary Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-118) - A Study to Evaluate the Effects of ER Niacin/Laropiprant, Laropiprant, ER Niacin, and Placebo on Urinary Prostanoid Metabolites (0524A-079)(COMPLETED) - A Study to Evaluate the Effects of Extended Release (ER) Niacin/Laropiprant, Laropiprant, ER Niacin, and Placebo on Urinary Prostanoid Metabolites in Subjects With High Cholesterol (0524A-075)(COMPLETED) - A Study to Evaluate the Effects of Laropiprant on the Antiplatelet Effects of Clopidogrel and Aspirin in Combination (MK-0524A-114)(COMPLETED) - A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of C16TR for Inhalation With Tyvaso® Cohort in Healthy Participants ### Drugs (9) - Alprostadil - Asapiprant Prostanoid DP receptor antagonist - Cloprostenol - Dinoprost - Dinoprostone - Iloprost - Laropiprant Prostanoid DP receptor antagonist - [Treprostinil](https://trialight.com/data/asset/treprostinil-002fe1ce-a63f-4f2b-9562-6cbff048a970.md) - Vidupiprant Prostanoid DP receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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