> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/psmd8-e3f774f9-ae1b-52d2-910c-a848c2f64e2c
> Record changed: 2026-10-13

# PSMD8

ENSG00000099341

Target class

Enzyme

Chromosome

19

Approved drugs

3

Clinical candidates (approved and in development)

5

## Clinical evidence

**Approved drugs**

3

**Clinical candidates (approved and in development)**

5

## Druggability

**Chemical probe available**

No

## Names

**Target name**

PSMD8

**Gene name**

Proteasome 26S subunit, non-ATPase 8

**Gene symbol**

PSMD8

**Protein name**

26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (26S proteasome regulatory subunit S14) (p31)

### Other names (6)

- S14
- Nin1p
- p31
- HIP6
- HYPF
- Rpn12

## Classification

**Gene biotype**

Protein coding

**Gene family**

Proteasome

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

194.71

**Tissue specificity (Gini)**

0.224

**Tissue specificity (tau)**

0.589

## Pathways and interactions

**KEGG gene identifiers**

- hsa:5714

**Protein interaction confidence**

0.935521

**Protein interaction partners**

71

### Reactome pathways (67)

- R-HSA-1169091
- R-HSA-1234176
- R-HSA-1236974
- R-HSA-1236978
- R-HSA-174084
- R-HSA-174113
- R-HSA-174154
- R-HSA-174178
- R-HSA-174184
- R-HSA-180534
- R-HSA-180585
- R-HSA-187577
- R-HSA-195253
- R-HSA-202424
- R-HSA-211733
- R-HSA-2467813
- R-HSA-2871837
- R-HSA-349425
- R-HSA-350562
- R-HSA-382556
- R-HSA-450408
- R-HSA-4608870
- R-HSA-4641257
- R-HSA-4641258
- R-HSA-5358346

And 42 more, listed on the interactive page.

## Genomic location

**End position**

38383850

**Start position**

38374563

**Chromosome**

19

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000099341

**HGNC ID**

HGNC:9566

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9566)

**NCBI Gene ID**

5714

**UniProt ID**

P48556

## Cellular location

- Cytosol
- Nuclear speckles

## Tissue expression

**Tissue specificity (tau)**

0.589445

**Expression inequality (Gini)**

0.223749

### Highest expression

Expression in transcripts per million

**Cells - Cultured fibroblasts**

194.71

**Muscle - Skeletal**

193.18

**Testis**

159.07

**Adipose - Subcutaneous**

131.42

**Cells - EBV-transformed lymphocytes**

128.69

### All tissues (54)

Expression in transcripts per million

- Cells - Cultured fibroblasts194.71
- Muscle - Skeletal193.18
- Testis159.07
- Adipose - Subcutaneous131.42
- Cells - EBV-transformed lymphocytes128.69
- Skin - Sun Exposed (Lower leg)119.73
- Skin - Not Sun Exposed (Suprapubic)112.2
- Artery - Aorta109.29
- Adipose - Visceral (Omentum)105.65
- Artery - Tibial104.26
- Breast - Mammary Tissue103.1
- Heart - Atrial Appendage103.03
- Artery - Coronary94.51
- Heart - Left Ventricle94.33
- Cervix - Ectocervix92.77
- Nerve - Tibial92.05
- Esophagus - Mucosa91.95
- Cervix - Endocervix91.13
- Uterus90.68
- Fallopian Tube89.88
- Lung89.46
- Esophagus - Muscularis88.09
- Esophagus - Gastroesophageal Junction84.84
- Vagina84.63
- Prostate83.89

And 29 more, listed on the interactive page.

## Biological functions

### Cellular components (5)

- GO:0000502  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000502)
- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005654  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0005838  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005838)

### Molecular functions

- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## Related records

### Trials (789)

- 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy
- 3D PET Myocardial Blood Flow and Rb82 Infusion Profiles
- 4SCAR-T Therapy Post CD19-targeted Immunotherapy
- A Basket Study of CTA313 in Participants With Active Autoimmune Diseases
- A Clinical Research About CD70-targeted CAR-NKT Cells Therapy Advanced Malignant Solid Tumors
- A Clinical Study Evaluating the Safety and Efficacy of BCMA-GPRC5D CAR-T in Patients With Relapsed/Refractory Multiple Myeloma Who Have Received Three or More Lines of Treatment
- A Clinical Study of BioTTT001 in Combination With SOX and Toripalimab in Patients With Gastric Cancer
- A Clinical Study of BioTTT001 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer
- A Clinical Study of CD19 CAR-T in Active Systemic Lupus Erythematosus
- A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors
- A Clinical Study of T3011 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer
- A Clinical Study on the Safety, Tolerance, and Preliminary Efficacy of γδ-T Cell Injection in the Treatment of Advanced Bladder Cancer
- A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma
- A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma
- A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis
- A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or Deletion
- A Hypoxia-Inducible CAR-T Cell Targeting AXL and CD73 for Advanced Gastric Cancer
- A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse."
- A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II
- A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy

### Drugs (5)

- Bortezomib D-mannitol 26S proteasome inhibitor
- [Carfilzomib](https://trialight.com/data/asset/carfilzomib-42f49602-1f34-4e14-b345-79d6fd69324f.md) 26S proteasome inhibitor
- Ixazomib 26S proteasome inhibitor
- Ixazomib citrate 26S proteasome inhibitor
- Oprozomib 26S proteasome inhibitor

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