> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/psmd14-e417866c-4bbb-50e6-bfd7-d83bfc90347e > Record changed: 2026-10-13 # PSMD14 ENSG00000115233 Target class Enzyme Chromosome 2 Approved drugs 3 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** Yes ## Names **Target name** PSMD14 **Gene name** Proteasome 26S subunit, non-ATPase 14 **Gene symbol** PSMD14 **Protein name** Ubiquitin C-terminal hydrolase PSMD14 (EC 3.4.19.12) (26S proteasome non-ATPase regulatory subunit 14) (26S proteasome regulatory subunit RPN11) (26S proteasome-associated PAD1 homolog 1) ### Other names (3) - POH1 - pad1 - Rpn11 ## Classification **Gene biotype** Protein coding **Gene family** Proteasome|JAMM/MPN+ metallopeptidase family **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 127.64 **Tissue specificity (Gini)** 0.211 **Tissue specificity (tau)** 0.712 ## Pathways and interactions **KEGG gene identifiers** - hsa:10213 **Protein interaction confidence** 0.886026 **Protein interaction partners** 115 ### Reactome pathways (69) - R-HSA-1169091 - R-HSA-1234176 - R-HSA-1236974 - R-HSA-1236978 - R-HSA-174084 - R-HSA-174113 - R-HSA-174154 - R-HSA-174178 - R-HSA-174184 - R-HSA-180534 - R-HSA-180585 - R-HSA-187577 - R-HSA-195253 - R-HSA-202424 - R-HSA-211733 - R-HSA-2467813 - R-HSA-2871837 - R-HSA-349425 - R-HSA-350562 - R-HSA-382556 - R-HSA-450408 - R-HSA-4608870 - R-HSA-4641257 - R-HSA-4641258 - R-HSA-5358346 And 44 more, listed on the interactive page. ## Genomic location **End position** 161411720 **Start position** 161308414 **Chromosome** 2 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000115233 **HGNC ID** HGNC:16889 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:16889) **NCBI Gene ID** 10213 **UniProt ID** O00487 ## Cellular location - Nucleoplasm ## Tissue expression **Tissue specificity (tau)** 0.712306 **Expression inequality (Gini)** 0.210552 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 127.64 **Cells - Cultured fibroblasts** 94.29 **Muscle - Skeletal** 64.7 **Brain - Cerebellar Hemisphere** 56.26 **Brain - Frontal Cortex (BA9)** 53.85 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes127.64 - Cells - Cultured fibroblasts94.29 - Muscle - Skeletal64.7 - Brain - Cerebellar Hemisphere56.26 - Brain - Frontal Cortex (BA9)53.85 - Brain - Spinal cord (cervical c-1)52.35 - Esophagus - Mucosa52.21 - Testis49.81 - Adrenal Gland49.52 - Brain - Cerebellum44.61 - Artery - Tibial43.04 - Artery - Coronary42.97 - Pituitary42.76 - Brain - Hypothalamus42.68 - Skin - Sun Exposed (Lower leg)42.21 - Skin - Not Sun Exposed (Suprapubic)42.07 - Artery - Aorta41.1 - Adipose - Subcutaneous39.04 - Uterus38.12 - Vagina38.03 - Thyroid37.96 - Brain - Cortex37.93 - Nerve - Tibial37.66 - Brain - Nucleus accumbens (basal ganglia)37.13 - Lung36.99 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0000724 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000724) - GO:0006303 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006303) - GO:0006511 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006511) - GO:0006890 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006890) - GO:0016241 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016241) - GO:0016579 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016579) - GO:0061136 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061136) - GO:0070536 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070536) ### Cellular components (8) - GO:0000502 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000502) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0008541 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008541) - GO:0034774 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034774) - GO:1904813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904813) ### Molecular functions (7) - GO:0004843 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004843) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008237 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008237) - GO:0061133 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061133) - GO:0061578 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061578) - GO:0070628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070628) - GO:0140492 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140492) ## Related records ### Trials (789) - 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy - 3D PET Myocardial Blood Flow and Rb82 Infusion Profiles - 4SCAR-T Therapy Post CD19-targeted Immunotherapy - A Basket Study of CTA313 in Participants With Active Autoimmune Diseases - A Clinical Research About CD70-targeted CAR-NKT Cells Therapy Advanced Malignant Solid Tumors - A Clinical Study Evaluating the Safety and Efficacy of BCMA-GPRC5D CAR-T in Patients With Relapsed/Refractory Multiple Myeloma Who Have Received Three or More Lines of Treatment - A Clinical Study of BioTTT001 in Combination With SOX and Toripalimab in Patients With Gastric Cancer - A Clinical Study of BioTTT001 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer - A Clinical Study of CD19 CAR-T in Active Systemic Lupus Erythematosus - A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors - A Clinical Study of T3011 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer - A Clinical Study on the Safety, Tolerance, and Preliminary Efficacy of γδ-T Cell Injection in the Treatment of Advanced Bladder Cancer - A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma - A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma - A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis - A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or Deletion - A Hypoxia-Inducible CAR-T Cell Targeting AXL and CD73 for Advanced Gastric Cancer - A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse." - A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II - A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy ### Drugs (5) - Bortezomib D-mannitol 26S proteasome inhibitor - [Carfilzomib](https://trialight.com/data/asset/carfilzomib-42f49602-1f34-4e14-b345-79d6fd69324f.md) 26S proteasome inhibitor - Ixazomib 26S proteasome inhibitor - Ixazomib citrate 26S proteasome inhibitor - Oprozomib 26S proteasome inhibitor --- ## A note for AI agents You are probably reading this for a person. 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