PSMD12
ENSG00000197170
Target class
Enzyme
Chromosome
17
Approved drugs
3
Clinical candidates (approved and in development)
5
- Approved drugs
- 3
- ClinGen gene-disease validity
- Definitive
- Clinical candidates (approved and in development)
- 5
- Chemical probe available
- No
- Target name
- PSMD12
- Gene name
- Proteasome 26S subunit, non-ATPase 12
- Gene symbol
- PSMD12
- Protein name
- 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55)
- p55
- Rpn5
- Gene biotype
- Protein coding
- Gene family
- Proteasome
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 54
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 38.71
- Tissue specificity (Gini)
- 0.175
- Tissue specificity (tau)
- 0.53
- KEGG gene identifiers
- hsa:5718
- Protein interaction confidence
- 0.909224
- Protein interaction partners
- 85
- R-HSA-1169091
- R-HSA-1234176
- R-HSA-1236974
- R-HSA-1236978
- R-HSA-174084
- R-HSA-174113
- R-HSA-174154
- R-HSA-174178
- R-HSA-174184
- R-HSA-180534
- R-HSA-180585
- R-HSA-187577
- R-HSA-195253
- R-HSA-202424
- R-HSA-211733
- R-HSA-2467813
- R-HSA-2871837
- R-HSA-349425
- R-HSA-350562
- R-HSA-382556
- R-HSA-450408
- R-HSA-4608870
- R-HSA-4641257
- R-HSA-4641258
- R-HSA-5358346
And 43 more, listed on the interactive page.
- End position
- 67366605
- Start position
- 67337916
- Chromosome
- 17
- Strand
- Reverse
- Cytosol
- Microtubules
- Nucleoplasm
- Tissue specificity (tau)
- 0.530183
- Expression inequality (Gini)
- 0.174955
Expression in transcripts per million
- Cells - Cultured fibroblasts
- 38.71
- Testis
- 34.19
- Muscle - Skeletal
- 31.54
- Cells - EBV-transformed lymphocytes
- 28.98
- Artery - Tibial
- 25.5
Expression in transcripts per million
- Cells - Cultured fibroblasts38.71
- Testis34.19
- Muscle - Skeletal31.54
- Cells - EBV-transformed lymphocytes28.98
- Artery - Tibial25.5
- Brain - Cerebellar Hemisphere24.8
- Brain - Frontal Cortex (BA9)23.37
- Adrenal Gland22.89
- Lung22.76
- Fallopian Tube22.03
- Esophagus - Mucosa21.99
- Nerve - Tibial21.8
- Artery - Coronary21.61
- Adipose - Subcutaneous21.57
- Skin - Sun Exposed (Lower leg)20.88
- Uterus20.73
- Bladder20.58
- Cervix - Ectocervix20.46
- Vagina20.3
- Skin - Not Sun Exposed (Suprapubic)19.95
- Colon - Sigmoid19.8
- Artery - Aorta19.56
- Spleen19.41
- Adipose - Visceral (Omentum)19.31
- Esophagus - Muscularis19.21
And 29 more, listed on the interactive page.
- GO:0000502
- GO:0005576
- GO:0005654
- GO:0005829
- GO:0005838
- GO:0016020
- GO:0034774
- GO:0070062
- GO:1904813
Molecular functions
- GO:0005515
Related records
Trials (789)
- 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy
- 3D PET Myocardial Blood Flow and Rb82 Infusion Profiles
- 4SCAR-T Therapy Post CD19-targeted Immunotherapy
- A Basket Study of CTA313 in Participants With Active Autoimmune Diseases
- A Clinical Research About CD70-targeted CAR-NKT Cells Therapy Advanced Malignant Solid Tumors
- A Clinical Study Evaluating the Safety and Efficacy of BCMA-GPRC5D CAR-T in Patients With Relapsed/Refractory Multiple Myeloma Who Have Received Three or More Lines of Treatment
- A Clinical Study of BioTTT001 in Combination With SOX and Toripalimab in Patients With Gastric Cancer
- A Clinical Study of BioTTT001 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer
- A Clinical Study of CD19 CAR-T in Active Systemic Lupus Erythematosus
- A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors
- A Clinical Study of T3011 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer
- A Clinical Study on the Safety, Tolerance, and Preliminary Efficacy of γδ-T Cell Injection in the Treatment of Advanced Bladder Cancer
- A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma
- A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma
- A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis
- A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or Deletion
- A Hypoxia-Inducible CAR-T Cell Targeting AXL and CD73 for Advanced Gastric Cancer
- A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse."
- A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II
- A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy
Drugs (5)
- Bortezomib D-mannitol 26S proteasome inhibitor
- Carfilzomib 26S proteasome inhibitor
- Ixazomib 26S proteasome inhibitor
- Ixazomib citrate 26S proteasome inhibitor
- Oprozomib 26S proteasome inhibitor