PSMC6
ENSG00000100519
Target class
Enzyme
Chromosome
14
Approved drugs
3
Clinical candidates (approved and in development)
5
- Approved drugs
- 3
- Clinical candidates (approved and in development)
- 5
- Chemical probe available
- No
- Target name
- PSMC6
- Gene name
- Proteasome 26S subunit, ATPase 6
- Gene symbol
- PSMC6
- Protein name
- 26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)
- p42
- RPT5
- Gene biotype
- Protein coding
- Gene family
- AAA ATPases|Proteasome
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 54
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 35.65
- Tissue specificity (Gini)
- 0.188
- Tissue specificity (tau)
- 0.35
- KEGG gene identifiers
- hsa:5706
- Protein interaction confidence
- 0.92194
- Protein interaction partners
- 67
- R-HSA-1169091
- R-HSA-1234176
- R-HSA-1236974
- R-HSA-1236978
- R-HSA-174084
- R-HSA-174113
- R-HSA-174154
- R-HSA-174178
- R-HSA-174184
- R-HSA-180534
- R-HSA-180585
- R-HSA-187577
- R-HSA-195253
- R-HSA-202424
- R-HSA-211733
- R-HSA-2467813
- R-HSA-2871837
- R-HSA-349425
- R-HSA-350562
- R-HSA-382556
- R-HSA-450408
- R-HSA-4608870
- R-HSA-4641257
- R-HSA-4641258
- R-HSA-5358346
And 43 more, listed on the interactive page.
- End position
- 52728590
- Start position
- 52707156
- Chromosome
- 14
- Strand
- Forward
- Cytoplasm . Nucleus .
- Cytosol
- Nucleoplasm
- Plasma membrane
- Tissue specificity (tau)
- 0.349657
- Expression inequality (Gini)
- 0.188112
Expression in transcripts per million
- Uterus
- 35.65
- Cells - EBV-transformed lymphocytes
- 35.46
- Ovary
- 34.6
- Cervix - Ectocervix
- 33.4
- Artery - Tibial
- 32.9
Expression in transcripts per million
- Uterus35.65
- Cells - EBV-transformed lymphocytes35.46
- Ovary34.6
- Cervix - Ectocervix33.4
- Artery - Tibial32.9
- Cervix - Endocervix32.71
- Brain - Cerebellar Hemisphere32.4
- Artery - Aorta32.18
- Nerve - Tibial32.17
- Thyroid31.81
- Fallopian Tube31.12
- Cells - Cultured fibroblasts31.08
- Vagina30.87
- Artery - Coronary30.73
- Esophagus - Mucosa30.12
- Lung30.11
- Muscle - Skeletal29.25
- Adipose - Subcutaneous28.56
- Breast - Mammary Tissue27.46
- Spleen27.01
- Brain - Cerebellum26.62
- Bladder26.3
- Pituitary25.64
- Skin - Not Sun Exposed (Suprapubic)25.09
- Prostate24.72
And 29 more, listed on the interactive page.
Biological processes
- GO:1901800
- GO:0000502
- GO:0005634
- GO:0005654
- GO:0005829
- GO:0016020
- GO:0070062
- GO:0005515
- GO:0036402
- GO:0042802
Related records
Trials (789)
- 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy
- 3D PET Myocardial Blood Flow and Rb82 Infusion Profiles
- 4SCAR-T Therapy Post CD19-targeted Immunotherapy
- A Basket Study of CTA313 in Participants With Active Autoimmune Diseases
- A Clinical Research About CD70-targeted CAR-NKT Cells Therapy Advanced Malignant Solid Tumors
- A Clinical Study Evaluating the Safety and Efficacy of BCMA-GPRC5D CAR-T in Patients With Relapsed/Refractory Multiple Myeloma Who Have Received Three or More Lines of Treatment
- A Clinical Study of BioTTT001 in Combination With SOX and Toripalimab in Patients With Gastric Cancer
- A Clinical Study of BioTTT001 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer
- A Clinical Study of CD19 CAR-T in Active Systemic Lupus Erythematosus
- A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors
- A Clinical Study of T3011 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer
- A Clinical Study on the Safety, Tolerance, and Preliminary Efficacy of γδ-T Cell Injection in the Treatment of Advanced Bladder Cancer
- A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma
- A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma
- A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis
- A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or Deletion
- A Hypoxia-Inducible CAR-T Cell Targeting AXL and CD73 for Advanced Gastric Cancer
- A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse."
- A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II
- A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy
Drugs (5)
- Bortezomib D-mannitol 26S proteasome inhibitor
- Carfilzomib 26S proteasome inhibitor
- Ixazomib 26S proteasome inhibitor
- Ixazomib citrate 26S proteasome inhibitor
- Oprozomib 26S proteasome inhibitor