PSMB6
ENSG00000142507
Target class
Enzyme
Chromosome
17
Approved drugs
3
Clinical candidates (approved and in development)
6
- Approved drugs
- 3
- Clinical candidates (approved and in development)
- 6
- Chemical probe available
- No
- Target name
- PSMB6
- Gene name
- Proteasome 20S subunit beta 6
- Gene symbol
- PSMB6
- Protein name
- Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y) (Proteasome subunit beta-1) (beta-1)
- Y
- DELTA
- Gene biotype
- Protein coding
- Gene family
- Proteasome
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 54
- Protein localisation evidence grade
- Supported
- Highest tissue expression
- 228.81
- Tissue specificity (Gini)
- 0.166
- Tissue specificity (tau)
- 0.403
- KEGG gene identifiers
- hsa:5694
- Protein interaction confidence
- 0.945746
- Protein interaction partners
- 59
- R-HSA-1169091
- R-HSA-1234176
- R-HSA-1236974
- R-HSA-1236978
- R-HSA-174084
- R-HSA-174113
- R-HSA-174154
- R-HSA-174178
- R-HSA-174184
- R-HSA-180534
- R-HSA-180585
- R-HSA-187577
- R-HSA-195253
- R-HSA-202424
- R-HSA-211733
- R-HSA-2467813
- R-HSA-2871837
- R-HSA-349425
- R-HSA-350562
- R-HSA-382556
- R-HSA-450408
- R-HSA-4608870
- R-HSA-4641257
- R-HSA-4641258
- R-HSA-5358346
And 43 more, listed on the interactive page.
- End position
- 4798503
- Start position
- 4796144
- Chromosome
- 17
- Strand
- Forward
- Cytoplasm . Nucleus . Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. .
- Cytosol
- Mitochondria
- Nucleoplasm
- PubMed 12181345
- PubMed 34711951
- Tissue specificity (tau)
- 0.402976
- Expression inequality (Gini)
- 0.165534
Expression in transcripts per million
- Muscle - Skeletal
- 228.81
- Artery - Tibial
- 215.89
- Artery - Aorta
- 203.53
- Artery - Coronary
- 196.01
- Cells - Cultured fibroblasts
- 190.82
Expression in transcripts per million
- Muscle - Skeletal228.81
- Artery - Tibial215.89
- Artery - Aorta203.53
- Artery - Coronary196.01
- Cells - Cultured fibroblasts190.82
- Uterus189.1
- Esophagus - Muscularis186.53
- Colon - Sigmoid186.42
- Esophagus - Mucosa182.33
- Cells - EBV-transformed lymphocytes182.21
- Esophagus - Gastroesophageal Junction180.86
- Cervix - Ectocervix177.2
- Skin - Sun Exposed (Lower leg)172.91
- Testis164.74
- Nerve - Tibial164.57
- Skin - Not Sun Exposed (Suprapubic)164.33
- Cervix - Endocervix163.36
- Bladder157.97
- Lung154.29
- Thyroid153.23
- Vagina150.19
- Adipose - Subcutaneous148.89
- Fallopian Tube147.69
- Kidney - Medulla144.47
- Pituitary143.17
And 29 more, listed on the interactive page.
- GO:0006979
- GO:0010498
- GO:0043161
- GO:0061136
- GO:0000502
- GO:0005634
- GO:0005654
- GO:0005737
- GO:0005829
- GO:0005839
- GO:0070062
- GO:0004298
- GO:0005515
- GO:0045296
Related records
Trials (799)
- 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy
- 3D PET Myocardial Blood Flow and Rb82 Infusion Profiles
- 4SCAR-T Therapy Post CD19-targeted Immunotherapy
- A Basket Study of CTA313 in Participants With Active Autoimmune Diseases
- A Clinical Research About CD70-targeted CAR-NKT Cells Therapy Advanced Malignant Solid Tumors
- A Clinical Study Evaluating the Safety and Efficacy of BCMA-GPRC5D CAR-T in Patients With Relapsed/Refractory Multiple Myeloma Who Have Received Three or More Lines of Treatment
- A Clinical Study of BioTTT001 in Combination With SOX and Toripalimab in Patients With Gastric Cancer
- A Clinical Study of BioTTT001 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer
- A Clinical Study of CD19 CAR-T in Active Systemic Lupus Erythematosus
- A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors
- A Clinical Study of T3011 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer
- A Clinical Study on the Safety, Tolerance, and Preliminary Efficacy of γδ-T Cell Injection in the Treatment of Advanced Bladder Cancer
- A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma
- A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma
- A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis
- A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or Deletion
- A Hypoxia-Inducible CAR-T Cell Targeting AXL and CD73 for Advanced Gastric Cancer
- A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse."
- A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II
- A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy
Drugs (6)
- Bortezomib D-mannitol 26S proteasome inhibitor
- Carfilzomib 26S proteasome inhibitor
- Ixazomib 26S proteasome inhibitor
- Ixazomib citrate 26S proteasome inhibitor
- Marizomib 20S proteasome inhibitor
- Oprozomib 26S proteasome inhibitor