> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/psenen-a97c4365-a6bd-511e-bf83-16ef20009315 > Record changed: 2026-10-13 # PSENEN ENSG00000205155 Target class Enzyme Chromosome 19 Approved drugs 2 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** No ## Names **Other names** - PEN2 **Target name** PSENEN **Gene name** Presenilin enhancer, gamma-secretase subunit **Gene symbol** PSENEN **Protein name** Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2) ## Classification **Gene biotype** Protein coding **Gene family** Gamma-secretase complex subunits **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 189.44 **Tissue specificity (Gini)** 0.202 **Tissue specificity (tau)** 0.79 ## Pathways and interactions **KEGG gene identifiers** - hsa:55851 **Protein interaction confidence** 0.8807 **Protein interaction partners** 20 ### Reactome pathways (13) - R-HSA-1251985 - R-HSA-193692 - R-HSA-205043 - R-HSA-2122948 - R-HSA-2644606 - R-HSA-2894862 - R-HSA-2979096 - R-HSA-3928665 - R-HSA-9013507 - R-HSA-9013700 - R-HSA-9017802 - R-HSA-977225 - R-HSA-9839383 ## Genomic location **End position** 35747519 **Start position** 35745070 **Chromosome** 19 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000205155 **HGNC ID** HGNC:30100 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:30100) **NCBI Gene ID** 55851 **UniProt ID** Q9NZ42 ## Cellular location - Endoplasmic reticulum membrane - Multi-pass membrane protein . Golgi apparatus, Golgi stack membrane - Multi-pass membrane protein . Cell membrane - Multi-pass membrane protein . Membrane - Multi-pass membrane protein . Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. . ### Publication evidence (9) - PubMed 12522139 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12522139/) - PubMed 12639958 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12639958/) - PubMed 25043039 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25043039/) - PubMed 26280335 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26280335/) - PubMed 26623517 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26623517/) - PubMed 30598546 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30598546/) - PubMed 30630874 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30630874/) - PubMed 24941111 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24941111/) - PubMed 12198112 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12198112/) ## Tissue expression **Tissue specificity (tau)** 0.789713 **Expression inequality (Gini)** 0.201703 ### Highest expression Expression in transcripts per million **Testis** 189.44 **Thyroid** 64.52 **Cervix - Endocervix** 58.98 **Pituitary** 56.46 **Whole Blood** 55.45 ### All tissues (54) Expression in transcripts per million - Testis189.44 - Thyroid64.52 - Cervix - Endocervix58.98 - Pituitary56.46 - Whole Blood55.45 - Cells - Cultured fibroblasts53.88 - Lung52.58 - Fallopian Tube52.5 - Nerve - Tibial52.38 - Cervix - Ectocervix50.82 - Brain - Spinal cord (cervical c-1)50.8 - Kidney - Medulla50.63 - Uterus49.9 - Esophagus - Mucosa49.19 - Spleen48.93 - Artery - Coronary46.34 - Artery - Aorta45.34 - Breast - Mammary Tissue45.01 - Prostate44.97 - Adrenal Gland44.92 - Vagina44.5 - Adipose - Visceral (Omentum)42.43 - Bladder42.05 - Adipose - Subcutaneous41.38 - Ovary41.19 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0006509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006509) - GO:0007220 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007220) - GO:0010950 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010950) - GO:0016485 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016485) - GO:0031293 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031293) - GO:0034205 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034205) - GO:0042982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042982) - GO:0042987 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042987) ### Cellular components (7) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0010008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0070765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070765) ### Molecular functions (3) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0061133 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061133) ## Related records ### Trials (117) - A Dose-escalation Study to Evaluate the Safety and Clinical Activity of PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma - A Multicenter, Double Blind, Placebo-Controlled, Safety and Tolerability Study of BMS-708163 in Patients With Prodromal Alzheimer's Disease - A Phase II, Multicenter, Double Blind, Placebo-Controlled Safety, Tolerability Study of BMS-708163 in Patients With Mild to Moderate Alzheimer's Disease - A Study Evaluating PF-03084014 In Patients With Advanced Breast Cancer With Or Without Notch Alterations - A Study Evaluating The PF-03084014 In Combination With Docetaxel In Patients With Advanced Breast Cancer - A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery - A Study of Belantamab Mafodotin in Combination With Nirogacestat and Pomalidomide in People With Multiple Myeloma That Has Not Responded to Treatment or Has Come Back After Treatment - A Study of Healthy Subjects to Assess the Effect of LY450139 on Amyloid Beta Peptide Production Rate and or Dose Response. - A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) - A Study Of PF-03084014 In Japanese Patients With Advanced Solid Tumors - A Study of RO4929097 in Patients With Advanced Renal Cell Carcinoma That Have Failed Vascular Endothelial Growth Factor (VEGF)/Vascular Endothelial Growth Factor Receptor (VEGFR) Therapy - A Study of Semagacestat for Alzheimer's Patients - A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma - A Study to Assess the Effects of 2 Different Prothrombin Complex Concentrates on the Pharmacodynamics of Rivaroxaban in Healthy Adult Volunteers - A Study to Assess the Effects of 2 Prothrombin Complex Concentrates on the Pharmacodynamics of Apixaban in Healthy Adult Subjects - [A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments](https://trialight.com/data/trial/a-study-to-examine-the-effects-of-novel-therapy-4622f07a-ab31-4a56-a46c-08b2e34a9258.md) - A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple Myeloma - A Trial In Patients With Advanced Cancer And Leukemia - A Two-part Study in Edoxaban-treated Healthy Subjects to Establish a Punch Biopsy Bleeding Model and to Evaluate the Effect of a 4-factor Prothrombin Complex Concentrate on Anticoagulation - Acute Dose-dependent Effects of DMT in Healthy Subjects ### Drugs (7) - Avagacestat Gamma-secretase inhibitor - Begacestat Gamma-secretase inhibitor - [Nirogacestat](https://trialight.com/data/asset/nirogacestat-3fcb771a-72a0-450b-adde-a88a42aee6e0.md) Gamma-secretase inhibitor - Nirogacestat hydrobromide Gamma-secretase inhibitor - RG-4733 Gamma-secretase inhibitor - Semagacestat Gamma-secretase inhibitor - Tarenflurbil Gamma-secretase modulator --- ## A note for AI agents You are probably reading this for a person. 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