> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/psen2-c4cb79da-7086-5973-8fac-76c58d524c87 > Record changed: 2026-10-13 # PSEN2 ENSG00000143801 Target class Ion channel Chromosome 1 Approved drugs 2 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 2 **ClinGen gene-disease validity** Limited **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** No ## Names **Target name** PSEN2 **Gene name** Presenilin 2 **Gene symbol** PSEN2 **Previous gene symbols** - AD4 **Protein name** Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) \[Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit\] ### Other names (5) - AD3L - STM2 - PS2 - PS-2 - E5-1 ## Classification **Gene biotype** Protein coding **Gene family** Presenilin family|Gamma-secretase complex subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 24.19 **Tissue specificity (Gini)** 0.244 **Tissue specificity (tau)** 0.469 ## Pathways and interactions **KEGG gene identifiers** - hsa:5664 **Protein interaction confidence** 0.869054 **Protein interaction partners** 37 ### Reactome pathways (12) - R-HSA-1251985 - R-HSA-193692 - R-HSA-205043 - R-HSA-2122948 - R-HSA-2644606 - R-HSA-2894862 - R-HSA-2979096 - R-HSA-3928665 - R-HSA-9013507 - R-HSA-9013700 - R-HSA-9017802 - R-HSA-9839383 ## Genomic location **End position** 226927726 **Start position** 226870184 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000143801 **HGNC ID** HGNC:9509 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9509) **NCBI Gene ID** 5664 **UniProt ID** P49810 ## Cellular location - Endoplasmic reticulum membrane - Multi-pass membrane protein . Golgi apparatus membrane - Multi-pass membrane protein . Late endosome membrane . Lysosome membrane . Note=Late endosome/lysosome localization is dependent of the phosphorylation-mediated interaction with the AP1G1 (PubMed:27293189). Also highly enriched in mitochondria-associated endoplasmic reticulum membrane contact site (By similarity). . ### Publication evidence (2) - PubMed 8574969 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8574969/) - PubMed 27293189 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27293189/) ## Tissue expression **Tissue specificity (tau)** 0.468812 **Expression inequality (Gini)** 0.244446 ### Highest expression Expression in transcripts per million **Uterus** 24.19 **Pituitary** 23.17 **Brain - Cerebellum** 22.92 **Esophagus - Muscularis** 22.61 **Testis** 22.19 ### All tissues (54) Expression in transcripts per million - Uterus24.19 - Pituitary23.17 - Brain - Cerebellum22.92 - Esophagus - Muscularis22.61 - Testis22.19 - Brain - Cerebellar Hemisphere22.06 - Prostate20.21 - Pancreas20.18 - Adrenal Gland19.74 - Fallopian Tube19.32 - Ovary19.21 - Esophagus - Gastroesophageal Junction19.13 - Colon - Sigmoid18.39 - Spleen18.35 - Lung16.47 - Bladder16.05 - Cervix - Ectocervix15.53 - Small Intestine - Terminal Ileum15.22 - Cervix - Endocervix15.03 - Thyroid14.8 - Artery - Aorta13.94 - Minor Salivary Gland13.68 - Vagina13.39 - Adipose - Subcutaneous13.31 - Breast - Mammary Tissue13.1 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0006509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006509) - GO:0007220 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007220) - GO:0016485 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016485) - GO:0034205 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034205) - GO:0035333 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035333) - GO:0042987 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042987) - GO:0110097 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0110097) - GO:1990456 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990456) ### Cellular components (15) - GO:0000139 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000139) - GO:0000776 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000776) - GO:0005637 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005637) - GO:0005764 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764) - GO:0005765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005765) - GO:0005770 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005770) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005813) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0031902 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031902) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) - GO:0070765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070765) ### Molecular functions (2) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0042500 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042500) ## Related records ### Trials (117) - A Dose-escalation Study to Evaluate the Safety and Clinical Activity of PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma - A Multicenter, Double Blind, Placebo-Controlled, Safety and Tolerability Study of BMS-708163 in Patients With Prodromal Alzheimer's Disease - A Phase II, Multicenter, Double Blind, Placebo-Controlled Safety, Tolerability Study of BMS-708163 in Patients With Mild to Moderate Alzheimer's Disease - A Study Evaluating PF-03084014 In Patients With Advanced Breast Cancer With Or Without Notch Alterations - A Study Evaluating The PF-03084014 In Combination With Docetaxel In Patients With Advanced Breast Cancer - A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery - A Study of Belantamab Mafodotin in Combination With Nirogacestat and Pomalidomide in People With Multiple Myeloma That Has Not Responded to Treatment or Has Come Back After Treatment - A Study of Healthy Subjects to Assess the Effect of LY450139 on Amyloid Beta Peptide Production Rate and or Dose Response. - A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) - A Study Of PF-03084014 In Japanese Patients With Advanced Solid Tumors - A Study of RO4929097 in Patients With Advanced Renal Cell Carcinoma That Have Failed Vascular Endothelial Growth Factor (VEGF)/Vascular Endothelial Growth Factor Receptor (VEGFR) Therapy - A Study of Semagacestat for Alzheimer's Patients - A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma - A Study to Assess the Effects of 2 Different Prothrombin Complex Concentrates on the Pharmacodynamics of Rivaroxaban in Healthy Adult Volunteers - A Study to Assess the Effects of 2 Prothrombin Complex Concentrates on the Pharmacodynamics of Apixaban in Healthy Adult Subjects - [A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments](https://trialight.com/data/trial/a-study-to-examine-the-effects-of-novel-therapy-4622f07a-ab31-4a56-a46c-08b2e34a9258.md) - A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple Myeloma - A Trial In Patients With Advanced Cancer And Leukemia - A Two-part Study in Edoxaban-treated Healthy Subjects to Establish a Punch Biopsy Bleeding Model and to Evaluate the Effect of a 4-factor Prothrombin Complex Concentrate on Anticoagulation - Acute Dose-dependent Effects of DMT in Healthy Subjects ### Drugs (7) - Avagacestat Gamma-secretase inhibitor - Begacestat Gamma-secretase inhibitor - [Nirogacestat](https://trialight.com/data/asset/nirogacestat-3fcb771a-72a0-450b-adde-a88a42aee6e0.md) Gamma-secretase inhibitor - Nirogacestat hydrobromide Gamma-secretase inhibitor - RG-4733 Gamma-secretase inhibitor - Semagacestat Gamma-secretase inhibitor - Tarenflurbil Gamma-secretase modulator --- ## A note for AI agents You are probably reading this for a person. 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