> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pros1-49fcaf80-511d-5393-ba90-0da1d6e96207 > Record changed: 2026-10-13 # PROS1 ENSG00000184500 Target class Unclassified protein Chromosome 3 Approved drugs 1 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Target name** PROS1 **Gene name** Protein S **Gene symbol** PROS1 **Previous gene symbols** - PROS **Protein name** Vitamin K-dependent protein S ## Classification **Gene biotype** Protein coding **Gene family** Gla domain containing **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Highest tissue expression** 167.53 **Tissue specificity (Gini)** 0.553 **Tissue specificity (tau)** 0.85 ## Pathways and interactions **KEGG gene identifiers** - hsa:5627 **Protein interaction confidence** 0.87725 **Protein interaction partners** 20 ### Reactome pathways (12) - R-HSA-114608 - R-HSA-159740 - R-HSA-159763 - R-HSA-159782 - R-HSA-202733 - R-HSA-9769735 - R-HSA-9769739 - R-HSA-9769743 - R-HSA-977606 - R-HSA-9918485 - R-HSA-9930449 - R-HSA-9930479 ## Genomic location **End position** 93980003 **Start position** 93873046 **Chromosome** 3 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000184500 **HGNC ID** HGNC:9456 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9456) **NCBI Gene ID** 5627 **UniProt ID** P07225 ## Cellular location - Secreted. ## Tissue expression **Tissue specificity (tau)** 0.849962 **Expression inequality (Gini)** 0.552804 ### Highest expression Expression in transcripts per million **Nerve - Tibial** 167.53 **Artery - Aorta** 164.19 **Artery - Coronary** 94.23 **Liver** 83.23 **Cells - Cultured fibroblasts** 65.11 ### All tissues (54) Expression in transcripts per million - Nerve - Tibial167.53 - Artery - Aorta164.19 - Artery - Coronary94.23 - Liver83.23 - Cells - Cultured fibroblasts65.11 - Artery - Tibial59.39 - Adipose - Subcutaneous50.63 - Ovary48.83 - Lung42.65 - Heart - Atrial Appendage41.45 - Adipose - Visceral (Omentum)40.53 - Breast - Mammary Tissue39.55 - Fallopian Tube39.43 - Esophagus - Gastroesophageal Junction35.9 - Esophagus - Muscularis35.25 - Thyroid32.79 - Cervix - Endocervix32.36 - Skin - Sun Exposed (Lower leg)31.25 - Uterus31.19 - Vagina26.44 - Cervix - Ectocervix25.73 - Colon - Sigmoid22.46 - Skin - Not Sun Exposed (Suprapubic)22.45 - Bladder21.36 - Small Intestine - Terminal Ileum20.06 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0007596 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007596) ### Cellular components (9) - GO:0000139 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000139) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0005796 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005796) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0031093 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031093) - GO:0031904 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031904) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0072562 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072562) ### Molecular functions (2) - GO:0004866 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004866) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (53) - A Study to Assess the Effects of 2 Different Prothrombin Complex Concentrates on the Pharmacodynamics of Rivaroxaban in Healthy Adult Volunteers - A Study to Assess the Effects of 2 Prothrombin Complex Concentrates on the Pharmacodynamics of Apixaban in Healthy Adult Subjects - A Study to Assess the Independent Effects of 4-Factor Prothrombin Complex Concentrate and Tranexamic Acid on Bleeding/Pharmacodynamics in Healthy Participants - A Study to Assess the Reversal of the Anticoagulant Effects of Milvexian by 4-Factor Prothrombin Complex Concentrate (4F-PCC) (Part 1) and Recombinant Human Factor VIIa (rFVIIa) (Part 2) in Healthy Participants - A Study to Evaluate Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of JNJ-64179375 in Healthy Male Subjects - A Two-part Study in Edoxaban-treated Healthy Subjects to Establish a Punch Biopsy Bleeding Model and to Evaluate the Effect of a 4-factor Prothrombin Complex Concentrate on Anticoagulation - Active-control Randomized Trial Comparing 4-factor Prothrombin Complex Concentrate With Frozen Plasma in Cardiac Surgery - Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation - An Observational Cohort Study to Investigate the Risk of Thromboembolic Events in Patients Receiving Kcentra® or Plasma to Reverse Vitamin K Antagonist (VKA) Therapy in the Setting of Acute Major Bleeding - An Open-label, Randomized, Multicenter Phase IIIb Study to Assess the Efficacy, Safety and Tolerance of BERIPLEX® P/N (Kcentra) Compared With Plasma for Rapid Reversal of Coagulopathy Induced by Vitamin K Antagonists in Subjects Requiring an Urgent Surgical Procedure - Assessment of Coagulation Factor Levels in Left Ventricular Device (LVAD )Patients Following Temporary Warfarin Reversal With Four Factor Prothrombin Complex Concentrate (4F-PCC) - Carboplatin + Paclitaxel + Cetuximab (PCC) After Failure of Pembrolizumab +/- First-line Chemotherapy in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck - Coagulation in Cirrhosis - CPP Versus PFC to Correct Coagulation Disorders in Adult Neurosurgical Patients - Efficacy and Safety of 4F-PCC (4-Factor Prothrombin Complex Concentrate) in Adult Patients Undergoing Complex Cardiovascular Surgery With Cardiopulmonary Bypass (CPB) - Efficacy and Safety of Early Use PCC in Severe Trauma - Efficacy and Safety of Prothromplex Total (Prothrombin Complex Concentrate) in Oral Anticoagulant Reversal - Efficacy and Safety Study of BERIPLEX® P/N (Kcentra) Compared With Plasma in Patients With Acute Major Bleeding Caused by Anticoagulant Therapy - Efficacy of Prothrombin Complex Concentrate Reducing Perioperative Blood Loss in Cardiac Surgery - [Evaluation of BE1116 in Patients With Traumatic Injury and Acute Major Bleeding to Improve Survival ( TAP Study )](https://trialight.com/data/trial/evaluation-of-be1116-in-patients-with-traumatic-injury-and-501a8ded-48b5-4d11-9428-8c99e00ce9b0.md) ### Drugs (2) - Protein S human Vitamin K-dependent protein S exogenous protein - [Prothrombin complex concentrate](https://trialight.com/data/asset/prothrombin-complex-concentrate-1ab4acb5-4b09-4890-a175-8f8ed7d4f12b.md) Vitamin K-dependent protein S exogenous protein --- ## A note for AI agents You are probably reading this for a person. 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