> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/proc-21df9453-9310-510f-ac64-f9566f5939ca > Record changed: 2026-10-13 # PROC ENSG00000115718 Target class Enzyme Chromosome 2 Approved drugs 1 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Target name** PROC **Gene name** Protein C, inactivator of coagulation factors Va and VIIIa **Gene symbol** PROC **Protein name** Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) \[Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide\] ## Classification **Gene biotype** Protein coding **Gene family** Receptor ligands|Gla domain containing **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 4 **Highest tissue expression** 241.55 **Tissue specificity (Gini)** 0.932 **Tissue specificity (tau)** 0.998 ## Pathways and interactions **KEGG gene identifiers** - hsa:5624 **Protein interaction confidence** 0.851088 **Protein interaction partners** 34 ### Reactome pathways (11) - R-HSA-159740 - R-HSA-159763 - R-HSA-159782 - R-HSA-202733 - R-HSA-381426 - R-HSA-8957275 - R-HSA-9769733 - R-HSA-9769739 - R-HSA-9769743 - R-HSA-9930449 - R-HSA-9930479 ## Genomic location **End position** 127429762 **Start position** 127415933 **Chromosome** 2 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000115718 **HGNC ID** HGNC:9451 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9451) **NCBI Gene ID** 5624 **UniProt ID** P04070 ## Cellular location - Secreted . Golgi apparatus . Endoplasmic reticulum . ### Publication evidence (3) - PubMed 25618265 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25618265/) - PubMed 22531345 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22531345/) - PubMed 25748729 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25748729/) ## Tissue expression **Tissue specificity (tau)** 0.997554 **Expression inequality (Gini)** 0.932319 ### Highest expression Expression in transcripts per million **Liver** 241.55 **Kidney - Cortex** 7.24 **Kidney - Medulla** 6.35 **Stomach** 1.91 **Brain - Hypothalamus** 0.85 ### All tissues (54) Expression in transcripts per million - Liver241.55 - Kidney - Cortex7.24 - Kidney - Medulla6.35 - Stomach1.91 - Brain - Hypothalamus0.85 - Small Intestine - Terminal Ileum0.64 - Brain - Nucleus accumbens (basal ganglia)0.62 - Artery - Tibial0.57 - Colon - Transverse0.55 - Brain - Amygdala0.53 - Brain - Frontal Cortex (BA9)0.46 - Bladder0.45 - Brain - Anterior cingulate cortex (BA24)0.43 - Artery - Coronary0.43 - Brain - Hippocampus0.43 - Artery - Aorta0.42 - Brain - Cortex0.42 - Pituitary0.41 - Brain - Caudate (basal ganglia)0.41 - Fallopian Tube0.4 - Brain - Substantia nigra0.37 - Whole Blood0.36 - Prostate0.35 - Brain - Cerebellum0.35 - Thyroid0.35 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0030195 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030195) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0050728 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050728) - GO:0050819 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050819) - GO:1903142 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903142) ### Cellular components (5) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005796 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005796) ### Molecular functions (2) - GO:0004252 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004252) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (535) - A Clinical Study of Intravenous Immunoglobulin - A Clinical Study to Evaluate the Safety and Efficacy of Anti-human CD 7 CAR-NK Cell Injection in Subjects With Relapsed and Refractory CD7-positive Hematological Malignancy - A Clinical Study to Test the Safety, Exposure, and Pharmacodynamic Markers of CSL311 in Patients With Mild-to-moderate Asthma and in Healthy Volunteers - A Comparison of TCC-EZ Using Human Amnion Allograft vs TCC-EZ and Standard Wound Care in Treating Diabetic Foot Ulcers. - A Controlled Study to Evaluate the Safety and Immunogenicity of StreptAnova™ in Healthy Adults - A Dose Escalation and Safety Study of Plasmin (Human) In Acute Lower Extremity Native Artery or Bypass Graft Occlusion - A Multicenter, Open-label, Randomized Controlled Trial Evaluating the Efficacy and Safety of Romiplostim N01 in the Treatment of Thrombocytopenia Associated With Concurrent/Sequential Chemoradiotherapy and Chemotherapy Combined With/Without Immunotherapy in Solid Tumors - A Novel Faecal Microbiota Transplantation System for Treatment of Primary and Recurrent Clostridium Difficile Infection - A Novel Therapeutic Treatment of Pyoderma Gangrenosum - A Phase 1 Study of ProMetic Plasminogen (Human) Intravenous in Adults and Children With Plasminogen Deficiency - A Phase 2 Open-label Study to Evaluate the Safety of Laruparetigene Zovaparvovec Administered Bilaterally in Male Participants With X-Linked Retinitis Pigmentosa - A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents - A Phase I Study of gp100 Human Melanoma Peptide Vaccine With Incomplete Freund's Adjuvant - A Phase I Trial Evaluate the Safety and Tolerability Profile of HPV Vaccine - A Phase I/II Study of Hyperimmune IVIG in Slowing Progression of Disease in HIV-Infected Children - A Phase I/III Clinical Study to Evaluate NouvNeu001 Injection for Multiple System Atrophy - A Phase II Trial Evaluate the Immunogenicity and Safety Profile of HPV Vaccine - A Phase Ⅲ Clinical Study of SNA02-48 Injection - A Phase III Randomized, Double-Blind, Controlled Study of the Use of Anti-HIV Immune Serum Globulin (HIVIG) for the Prevention of Maternal-Fetal HIV Transmission in Pregnant Women and Newborns Receiving Zidovudine (AZT) - A Phase III Study of a 2-dose Regimen of a Multivalent Human Papillomavirus (HPV) Vaccine (V503), Administered to 9 to 14 Year-olds and Compared to Young Women, 16 to 26 Years Old (V503-010) ### Drugs (2) - [Protein C concentrate (human)](https://trialight.com/data/asset/protein-c-concentrate-human-41664a77-cfe5-4593-a5d4-dd958f5e6bb7.md) Vitamin K-dependent protein C exogenous protein - [Prothrombin complex concentrate](https://trialight.com/data/asset/prothrombin-complex-concentrate-1ab4acb5-4b09-4890-a175-8f8ed7d4f12b.md) Vitamin K-dependent protein C exogenous protein --- ## A note for AI agents You are probably reading this for a person. 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