> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/prim1-c2f41ef1-9a92-5cd5-a6b1-e112bb5c39d3 > Record changed: 2026-10-13 # PRIM1 ENSG00000198056 Target class Enzyme Chromosome 12 Approved drugs 4 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 4 **ClinGen gene-disease validity** Moderate **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** No ## Names **Target name** PRIM1 **Gene name** DNA primase subunit 1 **Gene symbol** PRIM1 **Protein name** DNA primase small subunit (EC 2.7.7.102) (DNA primase 49 kDa subunit) (p49) ## Classification **Gene biotype** Protein coding **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 37.85 **Tissue specificity (Gini)** 0.407 **Tissue specificity (tau)** 0.873 ## Pathways and interactions **KEGG gene identifiers** - hsa:5557 **Protein interaction confidence** 0.879814 **Protein interaction partners** 59 ### Reactome pathways (9) - R-HSA-113501 - R-HSA-174411 - R-HSA-174430 - R-HSA-68952 - R-HSA-68962 - R-HSA-69091 - R-HSA-69166 - R-HSA-69183 - R-HSA-9710421 ## Genomic location **End position** 56752374 **Start position** 56730438 **Chromosome** 12 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000198056 **HGNC ID** HGNC:9369 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9369) **NCBI Gene ID** 5557 **UniProt ID** P49642 ## Tissue expression **Tissue specificity (tau)** 0.873453 **Expression inequality (Gini)** 0.406523 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 37.85 **Testis** 21.45 **Cells - Cultured fibroblasts** 11.68 **Brain - Cerebellar Hemisphere** 10.89 **Brain - Cerebellum** 10.28 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes37.85 - Testis21.45 - Cells - Cultured fibroblasts11.68 - Brain - Cerebellar Hemisphere10.89 - Brain - Cerebellum10.28 - Ovary8.59 - Spleen8.26 - Cervix - Ectocervix7.57 - Uterus7.13 - Skin - Not Sun Exposed (Suprapubic)7.08 - Vagina6.78 - Skin - Sun Exposed (Lower leg)6.61 - Fallopian Tube6.57 - Nerve - Tibial6.46 - Cervix - Endocervix6.41 - Small Intestine - Terminal Ileum6.3 - Esophagus - Mucosa6.11 - Breast - Mammary Tissue5.64 - Adipose - Subcutaneous5.32 - Lung5.24 - Minor Salivary Gland5.22 - Bladder5 - Thyroid4.64 - Pituitary4.55 - Colon - Transverse4.34 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0006269 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006269) - GO:0006270 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006270) ### Cellular components (3) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005658 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005658) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (5) - GO:0000287 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000287) - GO:0003899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003899) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008270 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008270) - GO:0032553 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032553) ## Related records ### Trials (4,736) - (PGA) for Platinum-resistant/Refractory, Paclitaxel-Pretreated Recurrent Ovarian and Peritoneal Carcinoma - (PM-01) IMPRIME PGG® With BTH1704 and Gemcitabine for Advanced Pancreatic Cancer - 1911GCCC: Galeterone With Gemcitabine for Patients With Metastatic Pancreatic Adenocarcinoma - 1st or 2nd Line MBC (Metastatic Breast Cancer) With Previous Avastin (Bevacizumab) Therapy - 2 Arm Study of Clofarabine IV in MDS Patients - 2-Chlorodeoxyadenosine and Cytarabine in Patients With Idiopathic Hypereosinophilic Syndrome (HES) - 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia - 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome - ²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myeloma - 225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome - 24BRO681 : Alternating Gnp and mFOLFIRINOX for BR-PDAC - 2nd Line Gemcitabine Monotherapy for Transitional Cell Carcinoma of Urothelium (TCC) After CDDP Regimen - 3-AP and Fludarabine in Treating Patients With Myeloproliferative Disorders, Chronic Myelomonocytic Leukemia, or Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia - 3-AP and Gemcitabine as Second-Line Therapy in Treating Patients With Stage III or Stage IV Recurrent Non-Small Cell Lung Cancer - 3-AP and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma - 3-AP and Gemcitabine in Treating Patients With Metastatic Non-Small Cell Lung Cancer - 3-AP and Gemcitabine in Treating Patients With Recurrent, Unresectable, or Metastatic Pancreatic Cancer - 3-AP and Gemcitabine in Treating Patients With Refractory Metastatic Breast Cancer - 3-AP and Gemcitabine in Treating Patients With Unresectable or Metastatic Pancreatic Cancer - 3-AP Followed By Fludarabine In Treating Patients With Relapsed or Refractory Acute or Chronic Leukemia or High-Risk Myelodysplastic Syndrome ### Drugs (7) - Aspacytarabine DNA polymerase (alpha/delta/epsilon) inhibitor - [Clofarabine](https://trialight.com/data/asset/clofarabine-df6136eb-4ce5-4462-8034-d6d6374f0221.md) DNA polymerase (alpha/delta/epsilon) inhibitor - Cytarabine DNA polymerase (alpha/delta/epsilon) inhibitor - [Fludarabine phosphate](https://trialight.com/data/asset/fludarabine-phosphate-6e2c2a2e-f158-4f63-89f8-381bbfac5aef.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [Gemcitabine](https://trialight.com/data/asset/gemcitabine-40c84c8f-1f08-4402-bce9-f31ff283382e.md) DNA polymerase (alpha/delta/epsilon) inhibitor - Gemcitabine hydrochloride DNA polymerase (alpha/delta/epsilon) inhibitor - Troxacitabine DNA polymerase (alpha/delta/epsilon) inhibitor --- ## A note for AI agents You are probably reading this for a person. 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