> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ppard-be176bfe-b8ce-510d-b733-dae26e29f9c7 > Record changed: 2026-11-04 # PPARD ENSG00000112033 Target class Nuclear receptor Chromosome 6 Approved drugs 3 Clinical candidates (approved and in development) 14 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 14 ## Druggability **Chemical probe available** Yes ## Names **Target name** PPARD **Gene name** Peroxisome proliferator activated receptor delta **Gene symbol** PPARD **Protein name** Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta) ### Other names (5) - NUC1 - NUCII - FAAR - NR1C2 - PPARB ## Classification **Gene biotype** Protein coding **Gene family** Peroxisome proliferator activated receptors **Target class** Nuclear receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 82.19 **Tissue specificity (Gini)** 0.229 **Tissue specificity (tau)** 0.621 ## Pathways and interactions **KEGG gene identifiers** - hsa:5467 **Protein interaction confidence** 0.790824 **Protein interaction partners** 34 ### Reactome pathways (3) - R-HSA-200425 - R-HSA-383280 - R-HSA-5362517 ## Genomic location **End position** 35428193 **Start position** 35342530 **Chromosome** 6 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000112033 **HGNC ID** HGNC:9235 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9235) **NCBI Gene ID** 5467 **UniProt ID** Q03181 ## Cellular location - Nucleus . ### Publication evidence - PubMed 35675826 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35675826/) ## Tissue expression **Tissue specificity (tau)** 0.621181 **Expression inequality (Gini)** 0.228771 ### Highest expression Expression in transcripts per million **Thyroid** 82.19 **Esophagus - Mucosa** 54.06 **Ovary** 53.03 **Vagina** 51.87 **Brain - Cerebellum** 46.72 ### All tissues (54) Expression in transcripts per million - Thyroid82.19 - Esophagus - Mucosa54.06 - Ovary53.03 - Vagina51.87 - Brain - Cerebellum46.72 - Prostate46.62 - Cells - Cultured fibroblasts46.22 - Spleen44.9 - Lung44.76 - Skin - Sun Exposed (Lower leg)43.5 - Cervix - Endocervix43.47 - Brain - Cerebellar Hemisphere42.24 - Uterus41.06 - Cervix - Ectocervix41.04 - Nerve - Tibial40.83 - Skin - Not Sun Exposed (Suprapubic)39.92 - Bladder39.59 - Fallopian Tube39.11 - Pituitary37.95 - Small Intestine - Terminal Ileum37.48 - Brain - Cortex36.76 - Colon - Sigmoid34.48 - Brain - Frontal Cortex (BA9)34.37 - Artery - Aorta34.25 - Breast - Mammary Tissue30.5 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (13) - GO:0006091 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006091) - GO:0006357 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006357) - GO:0006629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006629) - GO:0006635 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006635) - GO:0006915 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006915) - GO:0007566 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007566) - GO:0008203 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008203) - GO:0009062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009062) - GO:0031669 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031669) - GO:0045893 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045893) - GO:0046697 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046697) - GO:0097009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097009) - GO:0097190 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097190) ### Cellular components (2) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) ### Molecular functions (8) - GO:0001223 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001223) - GO:0003700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003700) - GO:0003707 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003707) - GO:0004879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004879) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008289 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008289) - GO:0070539 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070539) - GO:1990837 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990837) ## On-target safety - Increased, Liver Steatosis ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/36) ## Off-target safety - regulation of transcription factor activity ### Studies (5) - cell-based: ATG\_PPRE\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: ATG\_PPARd\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: TOX21\_PPARd\_BLA\_Agonist\_ratio is an assay readout measuring reporter gene via receptor activity and designed using inducible reporter (beta lactamase induction) detected with GAL4 b-lactamase reporter gene. The signal is derived from the ratio of cleaved (ch2) to uncleaved (ch1) reporter gene substrate used as the measure of target activity. - cell-based: TOX21\_PPARd\_BLA\_Antagonist\_ratio is an assay readout measuring reporter gene via receptor activity and designed using inducible reporter (beta lactamase induction) detected with GAL4 b-lactamase reporter gene. The signal is derived from the ratio of cleaved (ch2) to uncleaved (ch1) reporter gene substrate used as the measure of target activity. - cell-based: ATG\_PPRE\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. ### Biological samples (2) - HEK293T, cell line - HepG2, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (274) - "AIDA" Protocol (LAP 0493) - 90Y DOTA/Retinoic Acid for Neuroblastoma and Neuroendocrine Tumor (NET) - A Clinical Study Evaluating the Efficacy and Safety of Retinoic Acid in Patients With 15q11-q13 Duplication Syndrome - A Clinical Study to Evaluate the Safety and Effectiveness of an Investigational Product Called CT Gel - A Comparative Study of Adapalene Gel,0.3% Versus Tretinoin Emollient Cream, 0.05% for the Treatment of Photoaging - A Fixed Triple Combination Cream for Solar Lentigines Associated to Cryotherapy - A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis - A Pharmacokinetic Study of Lanifibranor in Healthy Adult Chinese Subjects - A Phase 2b/3 Clinical Study Evaluating T3D-959 in Mild-to-Moderate Alzheimer's Disease Subjects - A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 ) - A Phase II Clinical Trial of Chiglitazar for NASH - A Pilot Study of 5-AZA and ATRA for Prostate Cancer With PSA-only Recurrence After Local Treatment - A Post-Marketing Clinical Trial of Pemafibrate in Patients ｗith Hypercholesterolemia and Inadequate Response to Statins - A Prospective, Open, Self-controlled Study of the Effects of Chiglitazar Sodium on Glucose and Lipid Metabolism in Patients With Type 2 Diabetes Mellitus (T2DM) - A Single-arm Trial of Roxadustat Combined With Retinoic Acid in the Treatment of Refractory Low-risk MDS - A Study Comparing Combination Clindamycin Phosphate/Tretinoin Gel Alone Versus With Benzoyl Peroxide Foaming Cloths for Facial Acne - A Study Comparing Tretinoin Cream 0.025% and RETIN-A® Cream 0.025% in the Treatment of Acne Vulgaris - [A Study Comparing Tretinoin Gel Microsphere, 0.04% and RETIN-A MICRO ® Gel Microsphere, 0.04% in the Treatment of Acne Vulgaris](https://trialight.com/data/trial/a-study-comparing-tretinoin-gel-microsphere-0-04-and-retin-a-bceeb42d-138a-465f-8e49-d6992398bd3a.md) - A Study Comparing Tretinoin Gel Microsphere, 0.1% and RETIN-A MICRO ® Gel Microsphere, 0.1% in the Treatment of Acne Vulgaris - A Study of All-Trans Retinoic Acid (ATRA) and Bryostatin in Patients With Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) ### Drugs (16) - AVE0847 Peroxisome proliferator-activated receptor delta agonist - Bezafibrate Peroxisome proliferator-activated receptor agonist - CER-002 Peroxisome proliferator-activated receptor delta agonist - Chiglitazar Peroxisome proliferator-activated receptor agonist - DB959 Peroxisome proliferator-activated receptor delta agonist - Elafibranor Peroxisome proliferator-activated receptor delta agonist - Fonadelpar Peroxisome proliferator-activated receptor delta agonist - GW501516 Peroxisome proliferator-activated receptor delta agonist - Indeglitazar Peroxisome proliferator-activated receptor agonist - KD3010 Peroxisome proliferator-activated receptor delta agonist - Lanifibranor Peroxisome proliferator-activated receptor agonist - Pemafibrate - Seladelpar Peroxisome proliferator-activated receptor delta agonist - Seladelpar lysine Peroxisome proliferator-activated receptor delta agonist - Sodelglitazar Peroxisome proliferator-activated receptor agonist - [Tretinoin](https://trialight.com/data/asset/tretinoin-4d914613-55d9-4e09-ba53-7b0b1526992b.md) --- ## A note for AI agents You are probably reading this for a person. 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