> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pole2-38b134ac-c316-5bbf-85bf-984c1e39a855 > Record changed: 2026-10-13 # POLE2 ENSG00000100479 Target class Unclassified protein Chromosome 14 Approved drugs 4 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 4 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** No ## Names **Other names** - DPE2 **Target name** POLE2 **Gene name** DNA polymerase epsilon 2, accessory subunit **Gene symbol** POLE2 **Protein name** DNA polymerase epsilon subunit 2 (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B) ## Classification **Gene biotype** Protein coding **Gene family** DNA polymerases **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 28 **Protein localisation evidence grade** Supported **Highest tissue expression** 13.31 **Tissue specificity (Gini)** 0.488 **Tissue specificity (tau)** 0.897 ## Pathways and interactions **KEGG gene identifiers** - hsa:5427 **Protein interaction confidence** 0.874853 **Protein interaction partners** 75 ### Reactome pathways (10) - R-HSA-110314 - R-HSA-5651801 - R-HSA-5656169 - R-HSA-5685942 - R-HSA-5696397 - R-HSA-5696400 - R-HSA-6782135 - R-HSA-6782210 - R-HSA-68952 - R-HSA-68962 ## Genomic location **End position** 49688422 **Start position** 49643555 **Chromosome** 14 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000100479 **HGNC ID** HGNC:9178 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9178) **NCBI Gene ID** 5427 **UniProt ID** P56282 ## Cellular location - Nucleus. - Nuclear bodies - Nucleoplasm - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.896971 **Expression inequality (Gini)** 0.48822 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 13.31 **Cells - Cultured fibroblasts** 5.29 **Testis** 4.61 **Esophagus - Mucosa** 4.14 **Cervix - Ectocervix** 3.16 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes13.31 - Cells - Cultured fibroblasts5.29 - Testis4.61 - Esophagus - Mucosa4.14 - Cervix - Ectocervix3.16 - Vagina3.12 - Cervix - Endocervix3.01 - Small Intestine - Terminal Ileum2.42 - Uterus2.27 - Skin - Sun Exposed (Lower leg)2.19 - Ovary2.18 - Skin - Not Sun Exposed (Suprapubic)2.11 - Spleen2.04 - Colon - Transverse1.88 - Breast - Mammary Tissue1.83 - Fallopian Tube1.74 - Prostate1.71 - Nerve - Tibial1.69 - Adipose - Subcutaneous1.56 - Lung1.54 - Bladder1.52 - Thyroid1.46 - Minor Salivary Gland1.22 - Stomach1.2 - Artery - Coronary1.15 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0006260 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006260) - GO:0006261 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006261) - GO:0006281 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006281) ### Cellular components (3) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0008622 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008622) - GO:0016604 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016604) ### Molecular functions (2) - GO:0003887 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003887) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (4,736) - (PGA) for Platinum-resistant/Refractory, Paclitaxel-Pretreated Recurrent Ovarian and Peritoneal Carcinoma - (PM-01) IMPRIME PGG® With BTH1704 and Gemcitabine for Advanced Pancreatic Cancer - 1911GCCC: Galeterone With Gemcitabine for Patients With Metastatic Pancreatic Adenocarcinoma - 1st or 2nd Line MBC (Metastatic Breast Cancer) With Previous Avastin (Bevacizumab) Therapy - 2 Arm Study of Clofarabine IV in MDS Patients - 2-Chlorodeoxyadenosine and Cytarabine in Patients With Idiopathic Hypereosinophilic Syndrome (HES) - 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia - 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome - ²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myeloma - 225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome - 24BRO681 : Alternating Gnp and mFOLFIRINOX for BR-PDAC - 2nd Line Gemcitabine Monotherapy for Transitional Cell Carcinoma of Urothelium (TCC) After CDDP Regimen - 3-AP and Fludarabine in Treating Patients With Myeloproliferative Disorders, Chronic Myelomonocytic Leukemia, or Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia - 3-AP and Gemcitabine as Second-Line Therapy in Treating Patients With Stage III or Stage IV Recurrent Non-Small Cell Lung Cancer - 3-AP and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma - 3-AP and Gemcitabine in Treating Patients With Metastatic Non-Small Cell Lung Cancer - 3-AP and Gemcitabine in Treating Patients With Recurrent, Unresectable, or Metastatic Pancreatic Cancer - 3-AP and Gemcitabine in Treating Patients With Refractory Metastatic Breast Cancer - 3-AP and Gemcitabine in Treating Patients With Unresectable or Metastatic Pancreatic Cancer - 3-AP Followed By Fludarabine In Treating Patients With Relapsed or Refractory Acute or Chronic Leukemia or High-Risk Myelodysplastic Syndrome ### Drugs (7) - Aspacytarabine DNA polymerase (alpha/delta/epsilon) inhibitor - [Clofarabine](https://trialight.com/data/asset/clofarabine-df6136eb-4ce5-4462-8034-d6d6374f0221.md) DNA polymerase (alpha/delta/epsilon) inhibitor - Cytarabine DNA polymerase (alpha/delta/epsilon) inhibitor - [Fludarabine phosphate](https://trialight.com/data/asset/fludarabine-phosphate-6e2c2a2e-f158-4f63-89f8-381bbfac5aef.md) DNA polymerase (alpha/delta/epsilon) inhibitor - [Gemcitabine](https://trialight.com/data/asset/gemcitabine-40c84c8f-1f08-4402-bce9-f31ff283382e.md) DNA polymerase (alpha/delta/epsilon) inhibitor - Gemcitabine hydrochloride DNA polymerase (alpha/delta/epsilon) inhibitor - Troxacitabine DNA polymerase (alpha/delta/epsilon) inhibitor --- ## A note for AI agents You are probably reading this for a person. 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