> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/plk4-80601a0c-5c65-53d9-bb77-c6712de4f60c > Record changed: 2026-11-04 # PLK4 ENSG00000142731 Target class Kinase Chromosome 4 Approved drugs 0 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** Yes ## Names **Other names** - Sak **Target name** PLK4 **Gene name** Polo like kinase 4 **Gene symbol** PLK4 **Previous gene symbols** - STK18 **Protein name** Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) ## Classification **Gene biotype** Protein coding **Gene family** Polo like kinase family **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 20 **Protein localisation evidence grade** Supported **Highest tissue expression** 29.75 **Tissue specificity (Gini)** 0.674 **Tissue specificity (tau)** 0.95 ## Pathways and interactions **KEGG gene identifiers** - hsa:10733 **Protein interaction confidence** 0.826686 **Protein interaction partners** 70 ### Reactome pathways (7) - R-HSA-2565942 - R-HSA-380259 - R-HSA-380270 - R-HSA-380284 - R-HSA-380320 - R-HSA-5620912 - R-HSA-8854518 ## Genomic location **End position** 127899224 **Start position** 127880890 **Chromosome** 4 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000142731 **HGNC ID** HGNC:11397 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11397) **NCBI Gene ID** 10733 **UniProt ID** O00444 ## Cellular location - Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Nucleus, nucleolus . Cleavage furrow . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows. - Centrosome ### Publication evidence (6) - PubMed 22020124 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22020124/) - PubMed 27246242 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27246242/) - PubMed 27796307 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27796307/) - PubMed 30804208 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30804208/) - PubMed 32433990 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32433990/) - PubMed 16244668 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16244668/) ## Tissue expression **Tissue specificity (tau)** 0.949516 **Expression inequality (Gini)** 0.674154 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 29.75 **Testis** 24.17 **Cells - Cultured fibroblasts** 6.68 **Esophagus - Mucosa** 4.5 **Skin - Not Sun Exposed (Suprapubic)** 2.82 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes29.75 - Testis24.17 - Cells - Cultured fibroblasts6.68 - Esophagus - Mucosa4.5 - Skin - Not Sun Exposed (Suprapubic)2.82 - Skin - Sun Exposed (Lower leg)2.75 - Vagina2.23 - Small Intestine - Terminal Ileum2.14 - Spleen1.88 - Colon - Transverse1.58 - Ovary1.43 - Adipose - Subcutaneous1.43 - Cervix - Endocervix1.29 - Nerve - Tibial1.24 - Breast - Mammary Tissue1.23 - Cervix - Ectocervix1.21 - Lung1.18 - Uterus1.12 - Thyroid1.06 - Fallopian Tube1.05 - Bladder0.98 - Prostate0.95 - Adrenal Gland0.91 - Minor Salivary Gland0.9 - Brain - Nucleus accumbens (basal ganglia)0.87 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007099 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007099) - GO:0046601 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046601) - GO:0060271 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060271) ### Cellular components (4) - GO:0005813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005813) - GO:0005814 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005814) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0120098 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0120098) ### Molecular functions (4) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0106310 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106310) ## Related records ### Trials (203) - A Bioequivalence Study Of AG-013736 Tablets In Healthy Volunteers - A Bioequivalence Study Of AG-013736 Tablets Under Fed Conditions In Healthy Volunteers - A Dose Finding Study To Evaluate Safety, Drug Interaction, Tumor Markers Of Axitinib In Combination With MK-3475 In Adult Patients With Previously Untreated Advanced Renal Cell Cancer - A Multiple Ascending Dose Study of R1530 in Patients With Advanced Solid Tumors. - A Phase 1b Study Of Axitinib In Combination With Crizotinib In Patients With Advanced Solid Tumors - A Phase 2 Study in Patients With Advanced Non-Small Cell Lung Cancer Using New Agents With and Without Docetaxel. - A Phase II Study of Axitinib in Metastatic Non-clear Cell Renal Cell Carcinoma Patients Previously Treated With Temsirolimus - A Phase II Study of Axitinib in Patients With Metastatic Renal Cell Cancer Unsuitable for Nephrectomy - A Randomized Phase II Clinical Trial on the Efficacy of Axitinib as a Monotherapy or in Combination With Lomustine for the Treatment of Patients With Recurrent Glioblastoma - A Study Combining FOLFOX or FOLFIRI With AG-013736 or Bevacizumab (Avastin) in Patients With Metastatic Colorectal Cancer After Failure Of One First Line Regimen - A Study In Patients With Advanced Solid Tumor - A Study Of AG-013736 (Axitinib) Or Bevacizumab (Avastin) In Combination With Paclitaxel And Carboplatin In Patients With Advanced Lung Cancer. - A Study of AGS-16C3F vs. Axitinib in Metastatic Renal Cell Carcinoma - A Study of AK104 Monotherapy or AK104 Plus Axitinib in Advanced/Metastatic Renal Cell Carcinoma - A Study of AK104 Plus Axitinib in Advanced/Metastatic Special Pathological Subtypes of Renal Cell Carcinoma - A Study Of Avelumab In Combination With Axitinib In Advanced HCC (VEGF Liver 100) - A Study Of Avelumab In Combination With Axitinib In Advanced Renal Cell Cancer (JAVELIN Renal 100) - A Study of Avelumab in Combination With Axitinib In Non-Small Cell Lung Cancer (NSCLC) or Urothelial Cancer (Javelin Medley VEGF) - A Study of Avelumab In Combination With Axitinib in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumor After Failure of Standard Therapy - A Study of Avelumab With Axitinib Versus Sunitinib In Advanced Renal Cell Cancer (JAVELIN Renal 101) ### Drugs (4) - [Axitinib](https://trialight.com/data/asset/axitinib-5cec1625-dd7c-4136-ba51-99d1d8d813ec.md) - CFI-400945 Serine/threonine-protein kinase PLK4 inhibitor - Ocifisertib Serine/threonine-protein kinase PLK4 inhibitor - RG-1530 Serine/threonine-protein kinase PLK4 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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