> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/plg-ea48ec31-a3b4-5f69-a97d-4d887dd110ea > Record changed: 2026-10-13 # PLG ENSG00000122194 Target class Enzyme Chromosome 6 Approved drugs 5 Clinical candidates (approved and in development) 9 ## Clinical evidence **Approved drugs** 5 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 9 ## Druggability **Chemical probe available** No ## Names **Target name** PLG **Gene name** Plasminogen **Gene symbol** PLG **Protein name** Plasminogen (EC 3.4.21.7) \[Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B\] ## Classification **Gene biotype** Protein coding **Gene family** Kringle domain containing **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 3 **Protein localisation evidence grade** Approved **Highest tissue expression** 323.04 **Tissue specificity (Gini)** 0.976 **Tissue specificity (tau)** 0.999 ## Pathways and interactions **KEGG gene identifiers** - hsa:5340 **Protein interaction confidence** 0.86567 **Protein interaction partners** 106 ### Reactome pathways (6) - R-HSA-114608 - R-HSA-1474228 - R-HSA-1592389 - R-HSA-186797 - R-HSA-381426 - R-HSA-75205 ## Genomic location **End position** 160754097 **Start position** 160702105 **Chromosome** 6 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000122194 **HGNC ID** HGNC:9071 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9071) **NCBI Gene ID** 5340 **UniProt ID** P00747 ## Cellular location - Secreted . Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface. - Vesicles ### Publication evidence (2) - PubMed 10077593 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10077593/) - PubMed 14699093 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/14699093/) ## Tissue expression **Tissue specificity (tau)** 0.998574 **Expression inequality (Gini)** 0.976072 ### Highest expression Expression in transcripts per million **Liver** 323.04 **Kidney - Cortex** 19.15 **Kidney - Medulla** 3.64 **Testis** 0.19 **Cervix - Endocervix** 0.13 ### All tissues (54) Expression in transcripts per million - Liver323.04 - Kidney - Cortex19.15 - Kidney - Medulla3.64 - Testis0.19 - Cervix - Endocervix0.13 - Brain - Nucleus accumbens (basal ganglia)0.1 - Fallopian Tube0.1 - Ovary0.07 - Prostate0.07 - Brain - Cortex0.06 - Uterus0.06 - Lung0.05 - Brain - Caudate (basal ganglia)0.05 - Cervix - Ectocervix0.05 - Brain - Frontal Cortex (BA9)0.05 - Brain - Hypothalamus0.04 - Brain - Anterior cingulate cortex (BA24)0.04 - Pituitary0.04 - Brain - Putamen (basal ganglia)0.03 - Cells - EBV-transformed lymphocytes0.03 - Brain - Hippocampus0.03 - Vagina0.03 - Small Intestine - Terminal Ileum0.03 - Brain - Amygdala0.02 - Pancreas0.02 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (11) - GO:0006508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006508) - GO:0007596 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007596) - GO:0010812 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010812) - GO:0022617 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022617) - GO:0030574 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030574) - GO:0042730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042730) - GO:0043536 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043536) - GO:0051702 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051702) - GO:0051918 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051918) - GO:0051919 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051919) - GO:2000048 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000048) ### Cellular components (8) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009897) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0031012 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031012) - GO:0031093 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031093) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0072562 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072562) ### Molecular functions (12) - GO:0002020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002020) - GO:0004175 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004175) - GO:0004252 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004252) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008236 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008236) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0019900 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019900) - GO:0019904 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019904) - GO:0034185 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034185) - GO:0051087 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051087) - GO:1990405 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990405) ## Related records ### Trials (1,099) - "The Effect of Inhaled Nitroglycerin for COPD Patients - "The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors" - "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer" - "Topical Tranexamic Acid With Flap Fixation: A Novel Approach to Minimize Post-operative Drainage and Surgical Site Infection in Patients Undergoing Modified Radical Mastectomy" - 5-day Defibrotide Treatment for Hepatic SOS/VOD - A Clinical Observation of 1064-nm Q-Switched Fractional Laser Combined With Oral Tranexamic Acid on Treating of Melasma. - A Clinical Study Evaluating Inhaled Aviptadil on COVID-19 - A Comparison Study of Bypassing Agent Therapy With and Without Tranexamic Acid in Haemophilia A Patients With Inhibitor - A Multi-omics Study of Adenomyosis - A Multi-omics Study of Epithelial Ovarian Cancer - A Novel Inhaled Formulation of Melatonin to Treat Adults With Insomnia: Efficacy Study - A Novel Inhaled Formulation of Melatonin to Treat Adults With Insomnia: Pharmacokinetic Study - A Pediatric Trial Using Tranexamic Acid in Thrombocytopenia - A Phase 1, Double-Blind, Randomized, Single Dose Escalation Safety Study of Intra-articular OP-1 in Subjects With Osteoarthritis of the Knee - A Phase 2 Study to Determine the Safety and Efficacy of Inhaled Dry Powder Mannitol in Cystic Fibrosis - A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD) - A Phase I Clinical Trial of a mRNA Vaccine for Recurrent or Progressive High-grade Glioma - a Phase I PK Study in Healthy Male Subjects. 2 Groups of Healthy Male Subjects - A Phase I Study of Inhaled Sodium Pyruvate for the Treatment of Cystic Fibrosis. - A Phase IIb Trial of Pulmicort Turbuhaler (Budesonide) ### Drugs (9) - Amediplase Plasminogen activator - Aminocaproic acid Plasminogen inhibitor - Anistreplase Plasminogen activator - [Aprotinin](https://trialight.com/data/asset/aprotinin-08291457-b633-4aa3-ade1-d49a293d163b.md) Plasminogen inhibitor - Defibrotide Plasminogen activator - Defibrotide sodium Plasminogen activator - Desmoteplase Plasminogen activator - Streptokinase Plasminogen activator - Tranexamic acid Plasminogen inhibitor --- ## A note for AI agents You are probably reading this for a person. 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