PLG
ENSG00000122194
Target class
Enzyme
Chromosome
6
Approved drugs
5
Clinical candidates (approved and in development)
9
- Approved drugs
- 5
- ClinGen gene-disease validity
- Definitive
- Clinical candidates (approved and in development)
- 9
- Chemical probe available
- No
- Target name
- PLG
- Gene name
- Plasminogen
- Gene symbol
- PLG
- Protein name
- Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]
- Gene biotype
- Protein coding
- Gene family
- Kringle domain containing
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 3
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 323.04
- Tissue specificity (Gini)
- 0.976
- Tissue specificity (tau)
- 0.999
- KEGG gene identifiers
- hsa:5340
- Protein interaction confidence
- 0.86567
- Protein interaction partners
- 106
- R-HSA-114608
- R-HSA-1474228
- R-HSA-1592389
- R-HSA-186797
- R-HSA-381426
- R-HSA-75205
- End position
- 160754097
- Start position
- 160702105
- Chromosome
- 6
- Strand
- Forward
- Secreted . Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
- Vesicles
- PubMed 10077593
- PubMed 14699093
- Tissue specificity (tau)
- 0.998574
- Expression inequality (Gini)
- 0.976072
Expression in transcripts per million
- Liver
- 323.04
- Kidney - Cortex
- 19.15
- Kidney - Medulla
- 3.64
- Testis
- 0.19
- Cervix - Endocervix
- 0.13
Expression in transcripts per million
- Liver323.04
- Kidney - Cortex19.15
- Kidney - Medulla3.64
- Testis0.19
- Cervix - Endocervix0.13
- Brain - Nucleus accumbens (basal ganglia)0.1
- Fallopian Tube0.1
- Ovary0.07
- Prostate0.07
- Brain - Cortex0.06
- Uterus0.06
- Lung0.05
- Brain - Caudate (basal ganglia)0.05
- Cervix - Ectocervix0.05
- Brain - Frontal Cortex (BA9)0.05
- Brain - Hypothalamus0.04
- Brain - Anterior cingulate cortex (BA24)0.04
- Pituitary0.04
- Brain - Putamen (basal ganglia)0.03
- Cells - EBV-transformed lymphocytes0.03
- Brain - Hippocampus0.03
- Vagina0.03
- Small Intestine - Terminal Ileum0.03
- Brain - Amygdala0.02
- Pancreas0.02
And 29 more, listed on the interactive page.
- GO:0006508
- GO:0007596
- GO:0010812
- GO:0022617
- GO:0030574
- GO:0042730
- GO:0043536
- GO:0051702
- GO:0051918
- GO:0051919
- GO:2000048
- GO:0005576
- GO:0005886
- GO:0009897
- GO:0009986
- GO:0031012
- GO:0031093
- GO:0070062
- GO:0072562
- GO:0002020
- GO:0004175
- GO:0004252
- GO:0005102
- GO:0005515
- GO:0008236
- GO:0019899
- GO:0019900
- GO:0019904
- GO:0034185
- GO:0051087
- GO:1990405
Related records
Trials (1,099)
- "The Effect of Inhaled Nitroglycerin for COPD Patients
- "The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors"
- "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"
- "Topical Tranexamic Acid With Flap Fixation: A Novel Approach to Minimize Post-operative Drainage and Surgical Site Infection in Patients Undergoing Modified Radical Mastectomy"
- 5-day Defibrotide Treatment for Hepatic SOS/VOD
- A Clinical Observation of 1064-nm Q-Switched Fractional Laser Combined With Oral Tranexamic Acid on Treating of Melasma.
- A Clinical Study Evaluating Inhaled Aviptadil on COVID-19
- A Comparison Study of Bypassing Agent Therapy With and Without Tranexamic Acid in Haemophilia A Patients With Inhibitor
- A Multi-omics Study of Adenomyosis
- A Multi-omics Study of Epithelial Ovarian Cancer
- A Novel Inhaled Formulation of Melatonin to Treat Adults With Insomnia: Efficacy Study
- A Novel Inhaled Formulation of Melatonin to Treat Adults With Insomnia: Pharmacokinetic Study
- A Pediatric Trial Using Tranexamic Acid in Thrombocytopenia
- A Phase 1, Double-Blind, Randomized, Single Dose Escalation Safety Study of Intra-articular OP-1 in Subjects With Osteoarthritis of the Knee
- A Phase 2 Study to Determine the Safety and Efficacy of Inhaled Dry Powder Mannitol in Cystic Fibrosis
- A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)
- A Phase I Clinical Trial of a mRNA Vaccine for Recurrent or Progressive High-grade Glioma
- a Phase I PK Study in Healthy Male Subjects. 2 Groups of Healthy Male Subjects
- A Phase I Study of Inhaled Sodium Pyruvate for the Treatment of Cystic Fibrosis.
- A Phase IIb Trial of Pulmicort Turbuhaler (Budesonide)
Drugs (9)
- Amediplase Plasminogen activator
- Aminocaproic acid Plasminogen inhibitor
- Anistreplase Plasminogen activator
- Aprotinin Plasminogen inhibitor
- Defibrotide Plasminogen activator
- Defibrotide sodium Plasminogen activator
- Desmoteplase Plasminogen activator
- Streptokinase Plasminogen activator
- Tranexamic acid Plasminogen inhibitor