> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/plat-a3299700-f07b-5538-a04f-a846cd46af72 > Record changed: 2026-10-13 # PLAT ENSG00000104368 Target class Enzyme Chromosome 8 Approved drugs 4 Clinical candidates (approved and in development) 8 ## Clinical evidence **Approved drugs** 4 **ClinGen gene-disease validity** Disputed **Clinical candidates (approved and in development)** 8 ## Druggability **Chemical probe available** No ## Names **Target name** PLAT **Gene name** Plasminogen activator, tissue type **Gene symbol** PLAT **Protein name** Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) \[Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B\] ## Classification **Gene biotype** Protein coding **Gene family** Kringle domain containing **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Protein localisation evidence grade** Approved **Highest tissue expression** 102.93 **Tissue specificity (Gini)** 0.449 **Tissue specificity (tau)** 0.662 ## Pathways and interactions **KEGG gene identifiers** - hsa:5327 **Protein interaction confidence** 0.844116 **Protein interaction partners** 43 ### Reactome pathways (2) - R-HSA-186797 - R-HSA-75205 ## Genomic location **End position** 42207709 **Start position** 42174718 **Chromosome** 8 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000104368 **HGNC ID** HGNC:9051 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:9051) **NCBI Gene ID** 5327 **UniProt ID** P00750 ## Cellular location - Secreted, extracellular space. - Actin filaments ## Tissue expression **Tissue specificity (tau)** 0.661699 **Expression inequality (Gini)** 0.448842 ### Highest expression Expression in transcripts per million **Nerve - Tibial** 102.93 **Fallopian Tube** 96.07 **Bladder** 90.83 **Uterus** 88.84 **Adipose - Visceral (Omentum)** 78.64 ### All tissues (54) Expression in transcripts per million - Nerve - Tibial102.93 - Fallopian Tube96.07 - Bladder90.83 - Uterus88.84 - Adipose - Visceral (Omentum)78.64 - Kidney - Medulla78.51 - Colon - Sigmoid76.88 - Kidney - Cortex72.73 - Artery - Coronary72.63 - Cells - Cultured fibroblasts68.31 - Colon - Transverse65.02 - Artery - Aorta60.73 - Lung60.7 - Thyroid59.11 - Prostate57.25 - Breast - Mammary Tissue55.16 - Adrenal Gland51.78 - Cervix - Endocervix51.6 - Esophagus - Gastroesophageal Junction51.08 - Esophagus - Muscularis49.21 - Cervix - Ectocervix44.86 - Small Intestine - Terminal Ileum42.87 - Stomach40.89 - Vagina40.44 - Ovary33.51 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0006508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006508) - GO:0007596 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007596) - GO:0031639 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031639) - GO:0036211 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036211) - GO:0042730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042730) - GO:0045861 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045861) ### Cellular components (5) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0031012 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031012) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (4) - GO:0004252 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004252) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0051219 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051219) ## Off-target safety - regulation of gene expression ### Studies - cell-based: BSK\_BE3C\_tPA, is one of 11 assay component(s) measured or calculated from the BSK\_BE3C assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with fluorescence intensity signals by Enzyme-linked immunosorbent assay technology. ### Biological samples - bronchial epithelial cells, primary cell Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (453) - 'Thrombectomy in High-Risk Pulmonary Embolism - Device Versus Thrombolysis Netherlands': TORPEDO-NL - 1-year Clinical Outcomes in Recombinant Tissue Plasminogen Activator (Rt-PA) Treated Chinese Acute Ischaemic Stroke (AIS) Patients - 24 Hours Treatment with Alteplase in Patients with Ischemic Stroke - A Combination Efficacy Study in Africa of Two DNA-MVA-Env Protein or DNA-Env Protein HIV-1 Vaccine Regimens With PrEP - A Comparison of Two Protocol for Maxillary Molar Intrusion Buccal Miniscrew and TPA Versus Vertical Holding Appliance - A Controlled Study to Evaluate the Safety and Immunogenicity of StreptAnova™ in Healthy Adults - A Multicenter, Prospective, Randomized Controlled Trial to Evaluate the Efficacy of PCSK-9 Inhibitors in Delaying the Progression of Calcified Aortic Valve Disease - A New Treatment of Newly Diagnosed KIT Mutation CBF-Acute Myeloid Leukemia - A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion - A PhaseⅡ of Injection for Recombinant Human Tissue Plasminogen Kinase Derivative in Treatment of Acute Ischemic Stroke. - A Pilot Study Comparing Anti-Inflammatory Effects Of TXA Versus EACA In Pediatric Congenital Heart Surgery - A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion - A Randomized, Self-controlled Post-marketing Clinical Study on the Comparison of Shengbai Oral Liquid and Leucogen Tablets in the Treatment of Moderate Neutropenia Caused by Anti-tumor Drugs in Breast Cancer Patients - A Safety/Efficacy Study of Intra-coronary Tenecteplase During Balloon Angioplasty to Treat Heart Attacks - A Single-dose Study in Healthy Japanese Male Adults to Evaluate Pharmacokinetics and Pharmacodynamics of E5501 5 mg Tablet (Study E5501-J081-015) - A Study in Chinese Patients to Compare How Tenecteplase and Alteplase Given After a Stroke Improve Recovering of Physical Activity - A Study in Healthy Men to Compare 2 Different Formulations of Alteplase - A Study in Parkinson's Disease in Patients With Moderate to Severe Dyskinesia - A Study of Abciximab and Reteplase When Administered Prior to Catherization After a Myocardial Infarction (Finesse) - A Study of Anginera In Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery ### Drugs (8) - [Alteplase](https://trialight.com/data/asset/alteplase-89461f67-4f40-4a00-ae4c-727752018887.md) Tissue-type plasminogen activator exogenous protein - Aminocaproic acid Tissue-type plasminogen activator inhibitor - Duteplase Tissue-type plasminogen activator exogenous protein - Lanoteplase Tissue-type plasminogen activator exogenous protein - Monteplase Tissue-type plasminogen activator exogenous protein - Pamiteplase Tissue-type plasminogen activator exogenous protein - Reteplase Tissue-type plasminogen activator exogenous protein - [Tenecteplase](https://trialight.com/data/asset/tenecteplase-01f5448a-c2ca-4332-92f6-1d9ef8a99284.md) Tissue-type plasminogen activator exogenous protein --- ## A note for AI agents You are probably reading this for a person. 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