> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pikfyve-5d7458d7-14ab-5816-be7c-38b4d9de4ff7 > Record changed: 2026-10-13 # PIKFYVE ENSG00000115020 Target class Enzyme Chromosome 2 Approved drugs 0 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** Yes ## Names **Target name** PIKFYVE **Gene name** Phosphoinositide kinase, FYVE-type zinc finger containing **Gene symbol** PIKFYVE **Previous gene symbols** - PIP5K3 **Protein name** 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) ### Other names (6) - MGC40423 - KIAA0981 - PIP5K - p235 - ZFYVE29 - FAB1 ## Classification **Gene biotype** Protein coding **Gene family** Zinc fingers FYVE-type|DEP domain containing **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 21.22 **Tissue specificity (Gini)** 0.25 **Tissue specificity (tau)** 0.508 ## Pathways and interactions **KEGG gene identifiers** - hsa:200576 **Protein interaction confidence** 0.910182 **Protein interaction partners** 55 ### Reactome pathways (3) - R-HSA-1660514 - R-HSA-1660516 - R-HSA-1660517 ## Genomic location **End position** 208358755 **Start position** 208266234 **Chromosome** 2 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000115020 **HGNC ID** HGNC:23785 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:23785) **NCBI Gene ID** 200576 **UniProt ID** Q9Y2I7 ## Cellular location - Endosome membrane - Peripheral membrane protein . Early endosome membrane - Peripheral membrane protein. Cytoplasmic vesicle, phagosome membrane - Peripheral membrane protein . Late endosome membrane - Peripheral membrane protein . Note=Mainly associated with membranes of the late endocytic pathway. . ### Publication evidence (3) - PubMed 11706043 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11706043/) - PubMed 17556371 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17556371/) - PubMed 30612035 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30612035/) ## Tissue expression **Tissue specificity (tau)** 0.507673 **Expression inequality (Gini)** 0.249512 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 21.22 **Brain - Cerebellar Hemisphere** 20.51 **Nerve - Tibial** 20.13 **Brain - Cerebellum** 18.55 **Spleen** 17.37 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes21.22 - Brain - Cerebellar Hemisphere20.51 - Nerve - Tibial20.13 - Brain - Cerebellum18.55 - Spleen17.37 - Cells - Cultured fibroblasts16.95 - Cervix - Ectocervix16.41 - Cervix - Endocervix16.18 - Uterus15.65 - Testis15.47 - Thyroid14.97 - Ovary14.77 - Lung14.31 - Adipose - Subcutaneous14.25 - Fallopian Tube14.16 - Prostate12.66 - Artery - Coronary12.64 - Artery - Tibial12.38 - Artery - Aorta12.32 - Breast - Mammary Tissue12.3 - Pituitary12.01 - Vagina11.91 - Bladder11.36 - Adipose - Visceral (Omentum)11.29 - Small Intestine - Terminal Ileum10.96 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (15) - GO:0006661 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006661) - GO:0006898 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006898) - GO:0019065 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019065) - GO:0019886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019886) - GO:0030593 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030593) - GO:0032438 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032438) - GO:0034504 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034504) - GO:0042147 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042147) - GO:0090382 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090382) - GO:0090385 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090385) - GO:0141111 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0141111) - GO:1903100 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903100) - GO:1903426 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903426) - GO:1904562 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904562) - GO:2000785 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000785) ### Cellular components (6) - GO:0000139 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000139) - GO:0010008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008) - GO:0030670 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030670) - GO:0031901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031901) - GO:0031902 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031902) - GO:0045121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121) ### Molecular functions (6) - GO:0000285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000285) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016308 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016308) - GO:0043813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043813) - GO:0052810 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0052810) - GO:0106310 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106310) ## Related records ### Trials (25) - A Dose-escalation and Dose-expansion Phase I/Phase II Clinical Study of Dositinib Mesylate Tablets (90-1408) in the Treatment of Locally Advanced or Metastatic Non-small Cell Lung Cancer With Positive EGFR Mutation - A Phase 2a Proof of Concept Open-Label, Randomized, Controlled Study to Evaluate the Safety and Efficacy of MDI-1228-mesylate Gel Compared With Standard of Care Alone in Patients With Diabetic Foot Ulcers - A Phase I Study of IDP-73152 Mesylate in Health Male Volunteer - A Phase Ⅰ/Ⅱa Clinical Study of GEN-725 in Combination With Dositinib - A Phase IIa Clinical Study of Purinostat Mesylate for Injection in Patients With Peripheral T-Cell Lymphoma and Cutaneous T-Cell Lymphoma - A Phase III Clinical Study of Purinostat Mesylate for Injection in Patients With Diffuse Large B-cell Lymphoma - A Randomized, Double-blind, Placebo-controlled Clinical Study of the Oral IL-12/23 Inhibitor, STA-5326 Mesylate, Administered to Patients With Rheumatoid Arthritis to Determine Safety, Tolerability, Pharmacokinetic and Synovial Tissue Outcomes - A Study of LAM-002A for the Prevention of Progression of COVID-19 - A Study of MDI-1228\_mesylate Ophthalmic Solution in Healthy Adults - [A Study of SHR-1826 for Injection in Combination With Other Antitumor Therapies in Subjects With NSCLC](https://trialight.com/data/trial/a-study-of-shr-1826-for-injection-in-combination-with-other-86919d29-2cc1-484a-9a76-bbb048399924.md) - [A Trial of SHR-A2102 With Other Antitumor Therapies in Advanced Solid Tumors](https://trialight.com/data/trial/a-trial-of-shr-a2102-with-other-antitumor-therapies-in-32a3d640-e015-4bd7-b00a-473a7d4488b7.md) - Bioequivalence Study of Mesylate Imatinib Capsule in Chronic Myeloid Leukemia Body - Evaluating the Long-term Safety and Tolerability of Imatinib in Patients With Lymphangioleiomyomatosis (LAM) - Mid-and Long-term Efficacy of Ergot Alkaloids in the Treatment of Salivation in Patients With Parkinson's Disease. - Purinostat Mesylate Combined With Pomalidomide Capsules and Low-dose Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma - Safety, Tolerability, and Pharmacokinetics of CAL056 Mesylate in Patients With Resistant or Refractory Solid Tumors - STA-5326 in Crohn's Disease Patients - STA-5326 Meslylate to Treat Gut Inflammation Associated With Common Variable Immunodeficiency - Study of Purinostat Mesylate for Injection in the Treatment of Relapsed or Refractory B Cell-related Tumor-predominant - Study of PWT33597 Mesylate in Subjects With Advanced Malignancies ### Drugs (3) - Apilimod 1-phosphatidylinositol 3-phosphate 5-kinase inhibitor - Apilimod 1-phosphatidylinositol 3-phosphate 5-kinase inhibitor - [Apilimod mesylate](https://trialight.com/data/asset/apilimod-mesylate-2a01ca48-f560-4231-b26b-aa9fb9f4dd3e.md) 1-phosphatidylinositol 3-phosphate 5-kinase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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