> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pik3r2-c5a9439c-0e76-5ccf-b39e-f3c8a19e8bfc > Record changed: 2026-10-13 # PIK3R2 ENSG00000105647 Target class Enzyme Chromosome 19 Approved drugs 0 Clinical candidates (approved and in development) 26 ## Clinical evidence **Approved drugs** 0 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 26 ## Druggability **Chemical probe available** No ## Names **Target name** PIK3R2 **Gene name** Phosphoinositide-3-kinase regulatory subunit 2 **Gene symbol** PIK3R2 **Protein name** Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) ### Other names (4) - P85B - p85 - p85beta - p85-BETA ## Classification **Gene biotype** Protein coding **Gene family** SH2 domain containing **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 58.25 **Tissue specificity (Gini)** 0.258 **Tissue specificity (tau)** 0.511 ## Pathways and interactions **KEGG gene identifiers** - hsa:5296 **Protein interaction confidence** 0.903014 **Protein interaction partners** 143 ### Reactome pathways (48) - R-HSA-109704 - R-HSA-112399 - R-HSA-114604 - R-HSA-1257604 - R-HSA-1266695 - R-HSA-1433557 - R-HSA-1660499 - R-HSA-186763 - R-HSA-198203 - R-HSA-201556 - R-HSA-202424 - R-HSA-2029485 - R-HSA-210993 - R-HSA-2219530 - R-HSA-2424491 - R-HSA-2730905 - R-HSA-373753 - R-HSA-389357 - R-HSA-416476 - R-HSA-4420097 - R-HSA-512988 - R-HSA-5673001 - R-HSA-6811558 - R-HSA-8853659 - R-HSA-8980692 And 23 more, listed on the interactive page. ## Genomic location **End position** 18170541 **Start position** 18153160 **Chromosome** 19 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000105647 **HGNC ID** HGNC:8980 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8980) **NCBI Gene ID** 5296 **UniProt ID** O00459 ## Cellular location - Golgi apparatus ## Tissue expression **Tissue specificity (tau)** 0.510875 **Expression inequality (Gini)** 0.257879 ### Highest expression Expression in transcripts per million **Adrenal Gland** 58.25 **Brain - Cortex** 54.62 **Ovary** 54.12 **Brain - Frontal Cortex (BA9)** 48.7 **Pituitary** 47.6 ### All tissues (54) Expression in transcripts per million - Adrenal Gland58.25 - Brain - Cortex54.62 - Ovary54.12 - Brain - Frontal Cortex (BA9)48.7 - Pituitary47.6 - Cervix - Endocervix46.78 - Esophagus - Mucosa46.58 - Brain - Nucleus accumbens (basal ganglia)46.46 - Cells - Cultured fibroblasts44.24 - Brain - Anterior cingulate cortex (BA24)44.22 - Cervix - Ectocervix42.12 - Brain - Hippocampus41.25 - Uterus40.72 - Skin - Sun Exposed (Lower leg)37.48 - Fallopian Tube36.79 - Brain - Caudate (basal ganglia)36.52 - Vagina36.07 - Brain - Cerebellum36.06 - Skin - Not Sun Exposed (Suprapubic)35.08 - Brain - Amygdala34.69 - Bladder33.9 - Testis33.74 - Brain - Cerebellar Hemisphere33.32 - Prostate33.16 - Brain - Putamen (basal ganglia)28.11 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0010506 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010506) - GO:0043409 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043409) - GO:0043491 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043491) ### Cellular components - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (4) - GO:0001784 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001784) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019903 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019903) - GO:0030971 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030971) ## Related records ### Trials (197) - 5G-PEARL: Paxalisib in Malignant Brain Tumours - A 3-Part Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0980, the Effect of Food, and the Effect of Rabeprazole on the Pharmacokinetics of the Tablet - A Bioavailability and Pharmacokinetic Study of GDC-0032 in Healthy Volunteers - [A Clinical Study of Novel Pneumococcal Vaccine V118C in Children (V118C-002)](https://trialight.com/data/trial/a-clinical-study-of-novel-pneumococcal-vaccine-v118c-in-d6487b9b-a525-4860-bc13-9338ed58336d.md) - A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma - A Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma (NHL) and in Combination With Endocrine Therapy in Locally Advanced or Metastatic Hormone Receptor-Positive Breast Cancer - A Dose-escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of GDC-0032 in Combination With Docetaxel or With Paclitaxel in Patients With HER2-negative Locally Recurrent or Metastatic Breast Cancer or Non-small Cell Lung Cancer - A Drug Interaction Study of GDC-0032 Co-administered With Rifampin or Itraconazole in Healthy Volunteers - A Multicenter Phase I/II Trial of Abiraterone Acetate + BEZ235 in Metastatic, Castration-Resistant Prostate Cancer - A Pharmacokinetics Study to Assess Abiraterone Acetate Capsule and Tablet Formulations in Patients With Prostate Cancer - A Phase 1 Dose Escalation Study of VS-5584 Administered in Combination With VS-6063, in Subjects With Relapsed Malignant Mesothelioma - A Phase 2 Study of RTB101 as COVID-19 Post-Exposure Prophylaxis in Older Adults - A Phase I, Dose-finding Study of BEZ235 in Adult Patients With Relapsed or Refractory Acute Leukemia - A Phase I/II Study of BEZ235 in Patients With Advanced Solid Malignancies Enriched by Patients With Advanced Breast Cancer - A Phase I/II Study of BGT226 in Adult Patients With Advanced Solid Malignancies Including Patients With Advanced Breast Cancer - A Phase Ib Dose De-escalation Study With BYL719 in Premenopausal Patients With Locally Advanced or Metastatic Breast Cancer - [A Phase Ib Study of HS-10352 Plus Fulvestrant in Patients With Advanced Breast Cancer](https://trialight.com/data/trial/a-phase-ib-study-of-hs-10352-plus-fulvestrant-in-patients-605bb4d0-2890-4f1e-baa7-099019096c00.md) - A Phase Ib/II Study of BEZ235 and Trastuzumab in Patients With HER2-positive Breast Cancer Who Failed Prior to Trastuzumab - A Phase II Study of Orally Administered BEZ235 Monotherapy in Patients With Metastatic or Unresectable Malignant PEComa - A Phase II Study of PX-866 in Patients With Recurrent or Metastatic Castration Resistant Prostate Cancer ### Drugs (28) - Apitolisib PI3-kinase class I inhibitor - AZD-6482 PI3-kinase class I inhibitor - BGT-226 PI3-kinase class I inhibitor - BGT-226 FREE BASE PI3-kinase class I inhibitor - Buparlisib PI3-kinase class I inhibitor - [Dactolisib](https://trialight.com/data/asset/dactolisib-c690af54-bc20-4e80-bd3c-2db9669c43d1.md) PI3-kinase class I inhibitor - DS-7423 PI3-kinase class I inhibitor - [Gedatolisib](https://trialight.com/data/asset/gedatolisib-ab488a0b-b1b9-4660-9c36-3e706274ef7a.md) PI3-kinase class I inhibitor - GSK-1059615 PI3-kinase class I inhibitor - Izorlisib PI3-kinase class I inhibitor - Omipalisib PI3-kinase class I inhibitor - Panulisib PI3-kinase class I inhibitor - Paxalisib PI3-kinase class I inhibitor - PF-04691502 PI3-kinase class I inhibitor - Pictilisib PI3-kinase class I inhibitor - Pilaralisib PI3-kinase class I inhibitor - Puquitinib PI3-kinase class I inhibitor - Puquitinib mesylate dihydrate PI3-kinase class I inhibitor - PWT-33587 PI3-kinase class I inhibitor - Recilisib PI3-kinase class I inhibitor --- ## A note for AI agents You are probably reading this for a person. 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