> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pik3cg-cf34f1e3-ab4a-550a-9e84-6fb39401d9c1 > Record changed: 2026-10-13 # PIK3CG ENSG00000105851 Target class Enzyme Chromosome 7 Approved drugs 1 Clinical candidates (approved and in development) 31 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Moderate **Clinical candidates (approved and in development)** 31 ## Druggability **Chemical probe available** Yes ## Names **Target name** PIK3CG **Gene name** Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma **Gene symbol** PIK3CG **Protein name** Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K) ## Classification **Gene biotype** Protein coding **Gene family** Phosphatidylinositol 3-kinase family **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 8 **Protein localisation evidence grade** Supported **Highest tissue expression** 7.5 **Tissue specificity (Gini)** 0.645 **Tissue specificity (tau)** 0.902 ## Pathways and interactions **KEGG gene identifiers** - hsa:5294 **Protein interaction confidence** 0.861726 **Protein interaction partners** 84 ### Reactome pathways (9) - R-HSA-114604 - R-HSA-1257604 - R-HSA-1660499 - R-HSA-2219530 - R-HSA-389357 - R-HSA-392451 - R-HSA-6811558 - R-HSA-9027276 - R-HSA-9927354 ## Genomic location **End position** 106908980 **Start position** 106865278 **Chromosome** 7 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000105851 **HGNC ID** HGNC:8978 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8978) **NCBI Gene ID** 5294 **UniProt ID** P48736 ## Cellular location - Cytoplasm . Cell membrane . - Cytosol - Plasma membrane ### Publication evidence - PubMed 12163475 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12163475/) ## Tissue expression **Tissue specificity (tau)** 0.901912 **Expression inequality (Gini)** 0.64536 ### Highest expression Expression in transcripts per million **Whole Blood** 7.5 **Spleen** 5.79 **Testis** 4.97 **Cells - EBV-transformed lymphocytes** 4.37 **Lung** 2.39 ### All tissues (54) Expression in transcripts per million - Whole Blood7.5 - Spleen5.79 - Testis4.97 - Cells - EBV-transformed lymphocytes4.37 - Lung2.39 - Small Intestine - Terminal Ileum2.24 - Adipose - Visceral (Omentum)1.21 - Adipose - Subcutaneous1.2 - Colon - Transverse0.94 - Artery - Coronary0.93 - Thyroid0.88 - Minor Salivary Gland0.79 - Breast - Mammary Tissue0.78 - Artery - Aorta0.71 - Nerve - Tibial0.68 - Cervix - Endocervix0.65 - Uterus0.61 - Bladder0.6 - Stomach0.57 - Ovary0.57 - Fallopian Tube0.55 - Prostate0.49 - Colon - Sigmoid0.49 - Brain - Spinal cord (cervical c-1)0.44 - Cervix - Ectocervix0.44 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (25) - GO:0001819 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001819) - GO:0002250 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002250) - GO:0002407 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002407) - GO:0002679 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002679) - GO:0003376 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003376) - GO:0006954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0010595 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010595) - GO:0010818 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010818) - GO:0030593 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030593) - GO:0033628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033628) - GO:0035022 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035022) - GO:0035747 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035747) - GO:0042098 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042098) - GO:0042110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042110) - GO:0043303 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043303) - GO:0043406 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043406) - GO:0043491 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043491) - GO:0045087 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045087) - GO:0045765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045765) - GO:0046854 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046854) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0055118 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055118) - GO:0070527 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070527) - GO:0072672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072672) ### Cellular components (5) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005944) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (8) - GO:0004672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004672) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016303 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016303) - GO:0035005 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035005) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0046875 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046875) - GO:0046934 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046934) - GO:0106310 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106310) ## On-target safety - cardiac hypertrophy ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - autoimmunity ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - immune PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - cytogenic abnormality ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - cellular (genetic disorder) PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - heart disease ### Studies - preclinical: Highly important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Regulates contractility and pathological hypertrophy ### Biological samples - cardiovascular system PubMed 21283106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/) - rash ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - skin PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Decreased appetite ### Effects - Activation/Increase/Upregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - nausea ### Effects - Activation/Increase/Upregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Hyperglycaemia ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - metabolic PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - pancreatic steatosis ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - pancreas PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - cytopenia ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - blood PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - fatigue ### Effects - Activation/Increase/Upregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - weight loss ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - colitis ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - GI PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - lymphopenia ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - immune PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - breast cancer ### Effects - Activation/Increase/Upregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - glycosylated haemoglobin increase ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - metabolic PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - hypertension ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Related records ### Trials (273) - (CHANT)Real World Study of Duvelisib in the Treatment of Non-Hodgkin's Lymphoma (NHL) - 5G-PEARL: Paxalisib in Malignant Brain Tumours - A 3-Part Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0980, the Effect of Food, and the Effect of Rabeprazole on the Pharmacokinetics of the Tablet - A Bioavailability and Pharmacokinetic Study of GDC-0032 in Healthy Volunteers - [A Clinical Study of Novel Pneumococcal Vaccine V118C in Children (V118C-002)](https://trialight.com/data/trial/a-clinical-study-of-novel-pneumococcal-vaccine-v118c-in-d6487b9b-a525-4860-bc13-9338ed58336d.md) - A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma - A Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma (NHL) and in Combination With Endocrine Therapy in Locally Advanced or Metastatic Hormone Receptor-Positive Breast Cancer - A Dose-escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of GDC-0032 in Combination With Docetaxel or With Paclitaxel in Patients With HER2-negative Locally Recurrent or Metastatic Breast Cancer or Non-small Cell Lung Cancer - A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IPI-549 - A Double-Blind Study Evaluating Duvelisib in Subjects With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate Alone - A Drug Interaction Study of GDC-0032 Co-administered With Rifampin or Itraconazole in Healthy Volunteers - A Long-term, Continued Treatment and Follow-up Study in Participants With Hematologic Malignancies Treated With Duvelisib (IPI-145) - A Multicenter Phase I/II Trial of Abiraterone Acetate + BEZ235 in Metastatic, Castration-Resistant Prostate Cancer - A Pharmacokinetics Study to Assess Abiraterone Acetate Capsule and Tablet Formulations in Patients With Prostate Cancer - A Phase 1 Dose Escalation Study of VS-5584 Administered in Combination With VS-6063, in Subjects With Relapsed Malignant Mesothelioma - A Phase 1 Study of Duvelisib in Patients With Advanced Hematologic Malignancies - A Phase 1b/2 Study of IPI-145 Plus FCR in Previously Untreated, Younger Patients With CLL - A Phase 2 Study Comparing 2 Intermittent Dosing Schedules of Duvelisib in Participants With Indolent Non-Hodgkin Lymphoma - A Phase 2 Study of RTB101 as COVID-19 Post-Exposure Prophylaxis in Older Adults - A Phase 2a, Efficacy and Safety Study of Duvelisib in Mild Asthmatic Subjects ### Drugs (34) - Apitolisib PI3-kinase class I inhibitor - AZD-6482 PI3-kinase class I inhibitor - BGT-226 PI3-kinase class I inhibitor - BGT-226 FREE BASE PI3-kinase class I inhibitor - Buparlisib PI3-kinase class I inhibitor - CAL-263 PI3-kinase p110-gamma subunit inhibitor - [Dactolisib](https://trialight.com/data/asset/dactolisib-c690af54-bc20-4e80-bd3c-2db9669c43d1.md) PI3-kinase class I inhibitor - DS-7423 PI3-kinase class I inhibitor - Duvelisib PI3-kinase p110-gamma subunit inhibitor - Duvelisib monohydrate PI3-kinase p110-gamma subunit inhibitor - Eganelisib PI3-kinase p110-gamma subunit inhibitor - [Gedatolisib](https://trialight.com/data/asset/gedatolisib-ab488a0b-b1b9-4660-9c36-3e706274ef7a.md) PI3-kinase class I inhibitor - GSK-1059615 PI3-kinase class I inhibitor - Izorlisib PI3-kinase class I inhibitor - Omipalisib PI3-kinase class I inhibitor - Panulisib PI3-kinase class I inhibitor - Paxalisib PI3-kinase class I inhibitor - PF-04691502 PI3-kinase class I inhibitor - Pictilisib PI3-kinase class I inhibitor - Pilaralisib PI3-kinase class I inhibitor --- ## A note for AI agents You are probably reading this for a person. 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