> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pik3cb-97c45181-3c9e-530e-8a15-5b652b9b6958 > Record changed: 2026-10-13 # PIK3CB ENSG00000051382 Target class Enzyme Chromosome 3 Approved drugs 0 Clinical candidates (approved and in development) 31 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 31 ## Druggability **Chemical probe available** Yes ## Names **Target name** PIK3CB **Gene name** Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta **Gene symbol** PIK3CB **Previous gene symbols** - PIK3C1 **Protein name** Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1) ## Classification **Gene biotype** Protein coding **Gene family** Phosphatidylinositol 3-kinase family **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 28.01 **Tissue specificity (Gini)** 0.195 **Tissue specificity (tau)** 0.623 ## Pathways and interactions **KEGG gene identifiers** - hsa:5291 **Protein interaction confidence** 0.892834 **Protein interaction partners** 151 ### Reactome pathways (32) - R-HSA-109704 - R-HSA-112399 - R-HSA-114604 - R-HSA-1257604 - R-HSA-1660499 - R-HSA-186763 - R-HSA-198203 - R-HSA-201556 - R-HSA-202424 - R-HSA-2029485 - R-HSA-210993 - R-HSA-2219530 - R-HSA-2424491 - R-HSA-2730905 - R-HSA-373753 - R-HSA-389357 - R-HSA-4420097 - R-HSA-512988 - R-HSA-5673001 - R-HSA-6811558 - R-HSA-8853659 - R-HSA-9027276 - R-HSA-912526 - R-HSA-912631 - R-HSA-9673767 And 7 more, listed on the interactive page. ## Genomic location **End position** 138834957 **Start position** 138652336 **Chromosome** 3 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000051382 **HGNC ID** HGNC:8976 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8976) **NCBI Gene ID** 5291 **UniProt ID** P42338 ## Cellular location - Cytoplasm . Nucleus . Note=Interaction with PIK3R2 is required for nuclear localization and export. - Midbody - Nucleoli - Nucleoplasm - Vesicles ### Publication evidence - PubMed 21383062 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21383062/) ## Tissue expression **Tissue specificity (tau)** 0.62279 **Expression inequality (Gini)** 0.19475 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 28.01 **Thyroid** 22.15 **Brain - Cerebellum** 21.84 **Skin - Sun Exposed (Lower leg)** 20.33 **Skin - Not Sun Exposed (Suprapubic)** 19.87 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere28.01 - Thyroid22.15 - Brain - Cerebellum21.84 - Skin - Sun Exposed (Lower leg)20.33 - Skin - Not Sun Exposed (Suprapubic)19.87 - Brain - Frontal Cortex (BA9)18.19 - Brain - Cortex13.12 - Artery - Tibial12.63 - Vagina12.41 - Esophagus - Mucosa12.3 - Muscle - Skeletal11.98 - Esophagus - Muscularis11.87 - Adipose - Subcutaneous11.82 - Prostate11.63 - Breast - Mammary Tissue11.27 - Minor Salivary Gland11.27 - Artery - Aorta11 - Bladder10.97 - Fallopian Tube10.95 - Nerve - Tibial10.9 - Esophagus - Gastroesophageal Junction10.9 - Lung10.72 - Cells - Cultured fibroblasts10.46 - Cervix - Ectocervix10.43 - Cells - EBV-transformed lymphocytes10.34 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (21) - GO:0001952 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001952) - GO:0003376 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003376) - GO:0006935 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006935) - GO:0007169 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007169) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0010508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010508) - GO:0010595 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010595) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0016477 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016477) - GO:0030168 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030168) - GO:0033031 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033031) - GO:0035022 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035022) - GO:0042267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042267) - GO:0043491 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043491) - GO:0045429 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045429) - GO:0046854 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046854) - GO:0051898 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051898) - GO:0070527 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070527) - GO:1900747 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900747) - GO:1903671 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903671) - GO:2000369 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000369) ### Cellular components (5) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005730) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (4) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016303 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016303) - GO:0046934 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046934) - GO:0106310 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106310) ## Related records ### Trials (214) - 5G-PEARL: Paxalisib in Malignant Brain Tumours - A 3-Part Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0980, the Effect of Food, and the Effect of Rabeprazole on the Pharmacokinetics of the Tablet - A Bioavailability and Pharmacokinetic Study of GDC-0032 in Healthy Volunteers - [A Clinical Study of Novel Pneumococcal Vaccine V118C in Children (V118C-002)](https://trialight.com/data/trial/a-clinical-study-of-novel-pneumococcal-vaccine-v118c-in-d6487b9b-a525-4860-bc13-9338ed58336d.md) - A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma - A Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma (NHL) and in Combination With Endocrine Therapy in Locally Advanced or Metastatic Hormone Receptor-Positive Breast Cancer - A Dose-escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of GDC-0032 in Combination With Docetaxel or With Paclitaxel in Patients With HER2-negative Locally Recurrent or Metastatic Breast Cancer or Non-small Cell Lung Cancer - A Drug Interaction Study of GDC-0032 Co-administered With Rifampin or Itraconazole in Healthy Volunteers - A Multicenter Phase I/II Trial of Abiraterone Acetate + BEZ235 in Metastatic, Castration-Resistant Prostate Cancer - A Pharmacokinetics Study to Assess Abiraterone Acetate Capsule and Tablet Formulations in Patients With Prostate Cancer - A Phase 1 Dose Escalation Study of VS-5584 Administered in Combination With VS-6063, in Subjects With Relapsed Malignant Mesothelioma - A Phase 2 Study of RTB101 as COVID-19 Post-Exposure Prophylaxis in Older Adults - A Phase I, Dose-finding Study of BEZ235 in Adult Patients With Relapsed or Refractory Acute Leukemia - A Phase I/Ib Trial for the Evaluation of SAR260301 in Monotherapy or in Combination With Vemurafenib in Patients With Various Advanced Cancer - A Phase I/II Study of BEZ235 in Patients With Advanced Solid Malignancies Enriched by Patients With Advanced Breast Cancer - A Phase I/II Study of BGT226 in Adult Patients With Advanced Solid Malignancies Including Patients With Advanced Breast Cancer - A Phase I/IIa, First Time in Human, Study of GSK2636771 in Subjects With Advanced Solid Tumors With Phosphatase and Tensin Homolog (PTEN) Deficiency - A Phase Ib Dose De-escalation Study With BYL719 in Premenopausal Patients With Locally Advanced or Metastatic Breast Cancer - [A Phase Ib Study of HS-10352 Plus Fulvestrant in Patients With Advanced Breast Cancer](https://trialight.com/data/trial/a-phase-ib-study-of-hs-10352-plus-fulvestrant-in-patients-605bb4d0-2890-4f1e-baa7-099019096c00.md) - A Phase Ib/II Study of BEZ235 and Trastuzumab in Patients With HER2-positive Breast Cancer Who Failed Prior to Trastuzumab ### Drugs (33) - Apitolisib PI3-kinase class I inhibitor - AZD-6482 PI3-kinase class I inhibitor - AZD-8186 PI3-kinase p110-beta subunit inhibitor - BAY-1082439 PI3-kinase p110-beta subunit inhibitor - BGT-226 PI3-kinase class I inhibitor - BGT-226 FREE BASE PI3-kinase class I inhibitor - Buparlisib PI3-kinase class I inhibitor - [Dactolisib](https://trialight.com/data/asset/dactolisib-c690af54-bc20-4e80-bd3c-2db9669c43d1.md) PI3-kinase class I inhibitor - DS-7423 PI3-kinase class I inhibitor - Fimepinostat PI3-kinase p110-beta subunit inhibitor - [Gedatolisib](https://trialight.com/data/asset/gedatolisib-ab488a0b-b1b9-4660-9c36-3e706274ef7a.md) PI3-kinase class I inhibitor - GSK-1059615 PI3-kinase class I inhibitor - GSK-2636771 PI3-kinase p110-beta subunit inhibitor - Izorlisib PI3-kinase class I inhibitor - Omipalisib PI3-kinase class I inhibitor - Panulisib PI3-kinase class I inhibitor - Paxalisib PI3-kinase class I inhibitor - PF-04691502 PI3-kinase class I inhibitor - Pictilisib PI3-kinase class I inhibitor - Pilaralisib PI3-kinase class I inhibitor --- ## A note for AI agents You are probably reading this for a person. 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