> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pgr-4e536b31-8799-5ace-a427-be36fd8a5f9f > Record changed: 2026-10-13 # PGR ENSG00000082175 Target class Nuclear receptor Chromosome 11 Approved drugs 21 Clinical candidates (approved and in development) 34 ## Clinical evidence **Approved drugs** 21 **Clinical candidates (approved and in development)** 34 ## Druggability **Chemical probe available** Yes ## Names **Target name** PGR **Gene name** Progesterone receptor **Gene symbol** PGR **Protein name** Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) ### Other names (2) - PR - NR3C3 ## Classification **Gene biotype** Protein coding **Gene family** Nuclear receptor subfamily 3 group C **Target class** Nuclear receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 27 **Highest tissue expression** 111.01 **Tissue specificity (Gini)** 0.822 **Tissue specificity (tau)** 0.943 ## Pathways and interactions **KEGG gene identifiers** - hsa:5241 **Protein interaction confidence** 0.852589 **Protein interaction partners** 73 ### Reactome pathways (7) - R-HSA-1251985 - R-HSA-3371497 - R-HSA-383280 - R-HSA-4090294 - R-HSA-9018519 - R-HSA-9927418 - R-HSA-9927426 ## Genomic location **End position** 101129813 **Start position** 101029624 **Chromosome** 11 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000082175 **HGNC ID** HGNC:8910 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8910) **NCBI Gene ID** 5241 **UniProt ID** P06401 ## Cellular location - Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. - SUBCELLULAR LOCATION: \[Isoform A\]: Nucleus. Cytoplasm. Note=Mainly nuclear. - SUBCELLULAR LOCATION: \[Isoform 4\]: Mitochondrion outer membrane . ### Publication evidence - PubMed 23518922 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23518922/) ## Tissue expression **Tissue specificity (tau)** 0.942995 **Expression inequality (Gini)** 0.822294 ### Highest expression Expression in transcripts per million **Cervix - Endocervix** 111.01 **Uterus** 80.64 **Cervix - Ectocervix** 75.88 **Fallopian Tube** 45.14 **Ovary** 19.07 ### All tissues (54) Expression in transcripts per million - Cervix - Endocervix111.01 - Uterus80.64 - Cervix - Ectocervix75.88 - Fallopian Tube45.14 - Ovary19.07 - Vagina18.36 - Artery - Tibial13.87 - Artery - Aorta13.7 - Artery - Coronary9.17 - Prostate5.6 - Colon - Sigmoid5.11 - Esophagus - Muscularis4.02 - Breast - Mammary Tissue3.55 - Esophagus - Gastroesophageal Junction3.35 - Bladder3.05 - Adipose - Subcutaneous3.02 - Lung2.76 - Nerve - Tibial2.44 - Heart - Atrial Appendage2.41 - Testis2.15 - Colon - Transverse1.8 - Heart - Left Ventricle1.76 - Adrenal Gland1.7 - Pituitary1.64 - Spleen1.45 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0006355 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006355) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267) - GO:0010629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010629) - GO:0042326 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042326) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0050847 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050847) - GO:0051457 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051457) ### Cellular components (4) - GO:0000785 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000785) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (10) - GO:0000978 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000978) - GO:0001223 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001223) - GO:0001228 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001228) - GO:0003677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677) - GO:0003707 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003707) - GO:0004879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004879) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0051117 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051117) ## On-target safety - Contraceptive ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - reproductive PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Emergency contraceptives ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - reproductive PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - induction of medical abortion ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - reproductive PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Off-target safety - receptor binding ### Studies - biochemical: NVS\_NR\_hPR, is one of one assay component(s) measured or calculated from the NVS\_NR\_hPR assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Lysate-based radiodetection technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - regulation of steroid hormone biosynthetic process ### Studies (2) - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). ### Biological samples - H295R, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - regulation of transcription factor activity ### Studies (5) - cell-based - cell-based: To identify the compounds that activate PR signaling, a PR-UAS-bla GripTite cell line i.e. PR-UAS-bla HEK 293T (Invitrogen, Carlsbad, CA, USA) containing a beta-lactamase reporter gene under the control of an Upstream Activator Sequence (UAS) and a human PR-ligand binding domain/GAL4 DNA binding domain fusion protein was used to screen Tox21 10K compound library. - cell-based - cell-based: To identify the compounds that inhibit PR signaling, a PR-UAS-bla GripTite cell line i.e. PR-UAS-bla HEK293T (Invitrogen, Carlsbad, CA, USA) containing a beta-lactamase reporter gene under the control of an Upstream Activator Sequence (UAS) and a human PR-ligand binding domain/GAL4 DNA binding domain fusion protein was used to screen Tox21 10K compound library. The agonist used to activate the receptor for antagonist mode in screening was 1 nM promegestone. - cell-based ### Biological samples (2) - PR-UAS-bla-HEK293T, cell line - HepG2, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - regulation of steroid biosynthetic process ### Studies (6) - cell-based: CEETOX\_H295R\_OHPREG, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_OHPREG, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_OHPROG, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_PROG, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_PROG, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_OHPROG, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. ### Biological samples - H295R, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (2,152) - 'Levonorgestrel IUD Insertion After D&E Procedure - "E4/DRSP Endocrine Function, Metabolic Control and Hemostasis Study" - "Effect of CPA/EE Drug on Periodontal Tissue and hsCRP Levels in PCOS Patients With Gingivitis - "Quick-starting" of a New Combined Hormonal Contraceptive Pills, 15 mg Estetrol/3 mg Drospirenone VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition - "Quick-starting" of a Quadriphasic Contraceptive Pills, 1 - 3 mg Estradiol Valerate/ 2 - 3 mg Dienogest VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition - "Stair Step Study" - 12-week Safety Evaluation of Oral CS-0777 in Multiple Sclerosis Patients - 17 Alfa Hydroxyprogesterone Caproate Versus Natural Progesterone for the Prevention of Preterm Labor - 17-Alpha-Hydroxyprogesterone Caproate in Pregnant Women With Placenta Previa - 17-OHPC in Pregnancy: IM vs SC Routes - 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies - 17OHP-C Dosing Among Obese Pregnant Women - A 4-week Study of Mifepristone in the Prevention of Risperidone-induced Weight Gain in Healthy Male Volunteers - A Bioequivalence Study of IMPLANON and Radiopaque IMPLANON (34528)(P05720) - A Bioequivalence Study of Norgestimate /Ethinyl Estradiol (NGM/EE) Tablets Manufactured at 2 Different Facilities - A Clinical and Biological Research of Combined Chinese and Western Medicine in the Treatment of PCOS - A Clinical Observation Study of a Chinese Patent Medicine Combined With Tamsulosin in Improving Sleep and Nocturia Symptoms After Enucleation of the Prostate - A Clinical Pharmacological Study of Rabeprazole Sodium in Japanese Healthy Adult Male Volunteers (Study E3810) - A Clinical Phase I Study on GIC-1001 in Healthy Volunteers - A Clinical Study Evaluating the Relative Bioavailability of SHR7280 Dry Suspension and Tablets ### Drugs (34) - Allylestrenol Progesterone receptor agonist - Asoprisnil Progesterone receptor modulator - Chlormadinone acetate Progesterone receptor modulator - Cyproterone acetate Progesterone receptor agonist - Danazol Progesterone receptor agonist - Desogestrel Progesterone receptor agonist - [Drospirenone](https://trialight.com/data/asset/drospirenone-9b602c10-48da-4ba8-ace9-5b9f942ad491.md) Progesterone receptor agonist - Dydrogesterone Progesterone receptor agonist - Ethynodiol diacetate Progesterone receptor agonist - Etonogestrel Progesterone receptor agonist - Gestodene Progesterone receptor agonist - Hydroxyprogesterone caproate Progesterone receptor agonist - [Levonorgestrel](https://trialight.com/data/asset/levonorgestrel-39655add-4fa8-46e3-b2a3-c0338caf8c0b.md) Progesterone receptor agonist - Lonaprisan Progesterone receptor antagonist - [Medroxyprogesterone acetate](https://trialight.com/data/asset/medroxyprogesterone-acetate-5514a525-6952-4a47-8871-8a2425a74366.md) Progesterone receptor agonist - Megestrol acetate Progesterone receptor agonist - Mifepristone Progesterone receptor antagonist - Nomegestrol Progesterone receptor agonist - [Nomegestrol acetate](https://trialight.com/data/asset/nomegestrol-acetate-2dc212bb-4e53-49f4-acd2-2f2cd1a6169a.md) Progesterone receptor agonist - Norelgestromin Progesterone receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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